000140458 001__ 140458
000140458 005__ 20240501120107.0
000140458 0247_ $$2doi$$a10.1186/s13195-019-0466-3
000140458 0247_ $$2pmid$$apmid:30704537
000140458 0247_ $$2pmc$$apmc:PMC6357385
000140458 0247_ $$2altmetric$$aaltmetric:54998884
000140458 037__ $$aDZNE-2020-06780
000140458 041__ $$aEnglish
000140458 082__ $$a610
000140458 1001_ $$0P:(DE-2719)2813778$$aSakr, Fatemah A$$b0$$eFirst author
000140458 245__ $$aApplicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study.
000140458 260__ $$aLondon$$bBioMed Central$$c2019
000140458 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2019-01-31
000140458 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2019-12-01
000140458 3367_ $$2DRIVER$$aarticle
000140458 3367_ $$2DataCite$$aOutput Types/Journal article
000140458 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1714474310_8221
000140458 3367_ $$2BibTeX$$aARTICLE
000140458 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000140458 3367_ $$00$$2EndNote$$aJournal Article
000140458 520__ $$aCurrent methods of amyloid PET interpretation based on the binary classification of global amyloid signal fail to identify early phases of amyloid deposition. A recent analysis of 18F-florbetapir PET data from the Alzheimer's disease Neuroimaging Initiative cohort suggested a hierarchical four-stage model of regional amyloid deposition that resembles neuropathologic estimates and can be used to stage an individual's amyloid burden in vivo. Here, we evaluated the validity of this in vivo amyloid staging model in an independent cohort of older people with subjective memory complaints (SMC). We further examined its potential association with subtle cognitive impairments in this population at elevated risk for Alzheimer's disease (AD).The monocentric INSIGHT-preAD cohort includes 318 cognitively intact older individuals with SMC. All individuals underwent 18F-florbetapir PET scanning and extensive neuropsychological testing. We projected the regional amyloid uptake signal into the previously proposed hierarchical staging model of in vivo amyloid progression. We determined the adherence to this model across all cases and tested the association between increasing in vivo amyloid stage and cognitive performance using ANCOVA models.In total, 156 participants (49%) showed evidence of regional amyloid deposition, and all but 2 of these (99%) adhered to the hierarchical regional pattern implied by the in vivo amyloid progression model. According to a conventional binary classification based on global signal (SUVRCereb = 1.10), individuals in stages III and IV were classified as amyloid-positive (except one in stage III), but 99% of individuals in stage I and even 28% of individuals in stage II were classified as amyloid-negative. Neither in vivo amyloid stage nor conventional binary amyloid status was significantly associated with cognitive performance in this preclinical cohort.The proposed hierarchical staging scheme of PET-evidenced amyloid deposition generalizes well to data from an independent cohort of older people at elevated risk for AD. Future studies will determine the prognostic value of the staging approach for predicting longitudinal cognitive decline in older individuals at increased risk for AD.
000140458 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000140458 542__ $$2Crossref$$i2019-01-31$$uhttp://creativecommons.org/licenses/by/4.0/
000140458 588__ $$aDataset connected to CrossRef, PubMed,
000140458 650_2 $$2MeSH$$aAged
000140458 650_2 $$2MeSH$$aAged, 80 and over
000140458 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000140458 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000140458 650_2 $$2MeSH$$aAlzheimer Disease: psychology
000140458 650_2 $$2MeSH$$aAmyloid: metabolism
000140458 650_2 $$2MeSH$$aCognition: physiology
000140458 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging
000140458 650_2 $$2MeSH$$aCognitive Dysfunction: metabolism
000140458 650_2 $$2MeSH$$aCognitive Dysfunction: psychology
000140458 650_2 $$2MeSH$$aCohort Studies
000140458 650_2 $$2MeSH$$aDiagnostic Self Evaluation
000140458 650_2 $$2MeSH$$aFemale
000140458 650_2 $$2MeSH$$aFollow-Up Studies
000140458 650_2 $$2MeSH$$aHumans
000140458 650_2 $$2MeSH$$aMale
000140458 650_2 $$2MeSH$$aMemory: physiology
000140458 650_2 $$2MeSH$$aMental Status and Dementia Tests
000140458 7001_ $$0P:(DE-2719)2810708$$aGrothe, Michel J$$b1
000140458 7001_ $$0P:(DE-HGF)0$$aCavedo, Enrica$$b2
000140458 7001_ $$0P:(DE-2719)2812473$$aJelistratova, Irina$$b3
000140458 7001_ $$0P:(DE-HGF)0$$aHabert, Marie-Odile$$b4
000140458 7001_ $$0P:(DE-2719)2810283$$aDyrba, Martin$$b5
000140458 7001_ $$0P:(DE-HGF)0$$aGonzalez-Escamilla, Gabriel$$b6
000140458 7001_ $$0P:(DE-HGF)0$$aBertin, Hugo$$b7
000140458 7001_ $$0P:(DE-HGF)0$$aLocatelli, Maxime$$b8
000140458 7001_ $$0P:(DE-HGF)0$$aLehericy, Stephane$$b9
000140458 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b10
000140458 7001_ $$0P:(DE-HGF)0$$aDubois, Bruno$$b11
000140458 7001_ $$0P:(DE-HGF)0$$aHampel, Harald$$b12
000140458 7001_ $$0P:(DE-HGF)0$$agroup, INSIGHT-preAD study$$b13
000140458 7001_ $$0P:(DE-HGF)0$$aInitiative, Alzheimer Precision Medicine$$b14
000140458 7001_ $$0P:(DE-HGF)0$$aBakardjian, Hovagim$$b15
000140458 7001_ $$0P:(DE-HGF)0$$aBenali, Habib$$b16
000140458 7001_ $$0P:(DE-HGF)0$$aBertin, Hugo$$b17
000140458 7001_ $$0P:(DE-HGF)0$$aBonheur, Joel$$b18
000140458 7001_ $$0P:(DE-HGF)0$$aBoukadida, Laurie$$b19
000140458 7001_ $$0P:(DE-HGF)0$$aBoukerrou, Nadia$$b20
000140458 7001_ $$0P:(DE-HGF)0$$aCavedo, Enrica$$b21
000140458 7001_ $$0P:(DE-HGF)0$$aChiesa, Patrizia$$b22
000140458 7001_ $$0P:(DE-HGF)0$$aColliot, Olivier$$b23
000140458 7001_ $$0P:(DE-HGF)0$$aDubois, Bruno$$b24
000140458 7001_ $$0P:(DE-HGF)0$$aDubois, Marion$$b25
000140458 7001_ $$0P:(DE-HGF)0$$aEpelbaum, Stéphane$$b26
000140458 7001_ $$0P:(DE-HGF)0$$aGagliardi, Geoffroy$$b27
000140458 7001_ $$0P:(DE-HGF)0$$aGenthon, Remy$$b28
000140458 7001_ $$0P:(DE-HGF)0$$aHabert, Marie-Odile$$b29
000140458 7001_ $$0P:(DE-HGF)0$$aHampel, Harald$$b30
000140458 7001_ $$0P:(DE-HGF)0$$aHouot, Marion$$b31
000140458 7001_ $$0P:(DE-HGF)0$$aKas, Aurélie$$b32
000140458 7001_ $$0P:(DE-HGF)0$$aLamari, Foudil$$b33
000140458 7001_ $$0P:(DE-HGF)0$$aLevy, Marcel$$b34
000140458 7001_ $$0P:(DE-HGF)0$$aLista, Simone$$b35
000140458 7001_ $$0P:(DE-HGF)0$$aMetzinger, Christiane$$b36
000140458 7001_ $$0P:(DE-HGF)0$$aMochel, Fanny$$b37
000140458 7001_ $$0P:(DE-HGF)0$$aNyasse, Francis$$b38
000140458 7001_ $$0P:(DE-HGF)0$$aPoisson, Catherine$$b39
000140458 7001_ $$0P:(DE-HGF)0$$aPotier, Marie-Claude$$b40
000140458 7001_ $$0P:(DE-HGF)0$$aRevillon, Marie$$b41
000140458 7001_ $$0P:(DE-HGF)0$$aSantos, Antonio$$b42
000140458 7001_ $$0P:(DE-HGF)0$$aAndrade, Katia Santos$$b43
000140458 7001_ $$0P:(DE-HGF)0$$aSole, Marine$$b44
000140458 7001_ $$0P:(DE-HGF)0$$aSurtee, Mohmed$$b45
000140458 7001_ $$0P:(DE-HGF)0$$ade Schotten, Michel Thiebaud$$b46
000140458 7001_ $$0P:(DE-HGF)0$$aVergallo, Andrea$$b47
000140458 7001_ $$0P:(DE-HGF)0$$aYounsi, Nadjia$$b48
000140458 77318 $$2Crossref$$3journal-article$$a10.1186/s13195-019-0466-3$$b : Springer Science and Business Media LLC, 2019-01-31$$n1$$p15$$tAlzheimer's Research & Therapy$$v11$$x1758-9193$$y2019
000140458 773__ $$0PERI:(DE-600)2506521-X$$a10.1186/s13195-019-0466-3$$gVol. 11, no. 1, p. 15$$n1$$p15$$q11:1<15$$tAlzheimer's research & therapy$$v11$$x1758-9193$$y2019
000140458 8564_ $$uhttps://pub.dzne.de/record/140458/files/DZNE-2020-06780.pdf$$yOpenAccess
000140458 8564_ $$uhttps://pub.dzne.de/record/140458/files/DZNE-2020-06780.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000140458 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357385
000140458 909CO $$ooai:pub.dzne.de:140458$$popen_access$$popenaire$$pVDB$$pdriver$$pdnbdelivery
000140458 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2813778$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000140458 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810708$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000140458 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812473$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000140458 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810283$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000140458 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000026$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000140458 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0
000140458 9141_ $$y2019
000140458 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-08
000140458 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ
000140458 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-08
000140458 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bALZHEIMERS RES THER : 2021$$d2022-11-08
000140458 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-02-14T16:18:57Z
000140458 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-02-14T16:18:57Z
000140458 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000140458 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-08
000140458 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-08
000140458 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bALZHEIMERS RES THER : 2021$$d2022-11-08
000140458 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-08
000140458 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2022-11-08
000140458 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-08
000140458 9201_ $$0I:(DE-2719)1510100$$kAG Teipel$$lClinical Dementia Research (Rostock /Greifswald)$$x0
000140458 980__ $$ajournal
000140458 980__ $$aVDB
000140458 980__ $$aUNRESTRICTED
000140458 980__ $$aI:(DE-2719)1510100
000140458 9801_ $$aFullTexts
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2015.02.004$$o10.1016/j.jalz.2015.02.004
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/brain/awv050$$o10.1093/brain/awv050
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/s40478-016-0399-z$$o10.1186/s40478-016-0399-z
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1097/RLU.0000000000000547$$o10.1097/RLU.0000000000000547
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.58.12.1791$$o10.1212/WNL.58.12.1791
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/ana.24711$$o10.1002/ana.24711
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.0000000000004643$$o10.1212/WNL.0000000000004643
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/acps.12336$$o10.1111/acps.12336
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2016.02.002$$o10.1016/j.jalz.2016.02.002
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.0000000000002153$$o10.1212/WNL.0000000000002153
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1474-4422(18)30029-2$$o10.1016/S1474-4422(18)30029-2
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1474-4422(12)70142-4$$o10.1016/S1474-4422(12)70142-4
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2967/jnumed.111.090340$$o10.2967/jnumed.111.090340
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0022-3956(75)90026-6$$o10.1016/0022-3956(75)90026-6
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0035-3787(07)90392-6$$o10.1016/S0035-3787(07)90392-6
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1080/01688638408401233$$o10.1080/01688638408401233
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/arclin/acw083$$o10.1093/arclin/acw083
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0028-3932(68)90038-9$$o10.1016/0028-3932(68)90038-9
000140458 999C5 $$2Crossref$$oD Cardebat 1990$$y1990
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fpsyg.2014.00772$$o10.3389/fpsyg.2014.00772
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1076/clin.13.1.30.1976$$o10.1076/clin.13.1.30.1976
000140458 999C5 $$2Crossref$$oD Wechsler WMS-III Wechsler memory scale-third edition 1997$$tWMS-III Wechsler memory scale-third edition$$y1997
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1177/1073191108315611$$o10.1177/1073191108315611
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0887-6177(03)00039-8$$o10.1016/S0887-6177(03)00039-8
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.55.11.1621$$o10.1212/WNL.55.11.1621
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s12149-017-1221-0$$o10.1007/s12149-017-1221-0
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/jcbfm.1992.81$$o10.1038/jcbfm.1992.81
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2006.01.021$$o10.1016/j.neuroimage.2006.01.021
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2016.12.077$$o10.1016/j.neuroimage.2016.12.077
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2014.07.003$$o10.1016/j.jalz.2014.07.003
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2967/jnumed.115.171652$$o10.2967/jnumed.115.171652
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2967/jnumed.112.109009$$o10.2967/jnumed.112.109009
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1001/jama.2010.2008$$o10.1001/jama.2010.2008
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1001/archneurol.2011.150$$o10.1001/archneurol.2011.150
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2015.05.018$$o10.1016/j.jalz.2015.05.018
000140458 999C5 $$2Crossref$$oS Salloway 2017$$y2017
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/brain/awv112$$o10.1093/brain/awv112
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/ggi.12374$$o10.1111/ggi.12374
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3233/JAD-160291$$o10.3233/JAD-160291
000140458 999C5 $$2Crossref$$oKV Papp 2017$$y2017
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/alzrt222$$o10.1186/alzrt222
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2017.04.004$$o10.1016/j.neurobiolaging.2017.04.004
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1001/jama.2017.6669$$o10.1001/jama.2017.6669
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s11065-017-9345-5$$o10.1007/s11065-017-9345-5
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2014.04.520$$o10.1016/j.jalz.2014.04.520
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1017/S1355617708080302$$o10.1017/S1355617708080302
000140458 999C5 $$2Crossref$$oJB Langbaum 2015$$y2015
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuropsychologia.2012.08.011$$o10.1016/j.neuropsychologia.2012.08.011
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/BF00308809$$o10.1007/BF00308809
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1136/jnnp-2017-316851$$o10.1136/jnnp-2017-316851
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1365-2990.2011.01219.x$$o10.1111/j.1365-2990.2011.01219.x
000140458 999C5 $$2Crossref$$oEM Arenaza-Urquijo 2018$$y2018
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1162/jocn_a_00300$$o10.1162/jocn_a_00300
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2015.05.001$$o10.1016/j.jalz.2015.05.001
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.0b013e318245d295$$o10.1212/WNL.0b013e318245d295
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1212/WNL.0b013e31826e2696$$o10.1212/WNL.0b013e31826e2696
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2967/jnumed.108.057612$$o10.2967/jnumed.108.057612
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1177/0271678X18783628$$o10.1177/0271678X18783628
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2967/jnumed.116.184481$$o10.2967/jnumed.116.184481
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00259-011-1745-9$$o10.1007/s00259-011-1745-9
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2014.11.058$$o10.1016/j.neuroimage.2014.11.058
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2014.11.055$$o10.1016/j.neuroimage.2014.11.055
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2016.09.028$$o10.1016/j.neuroimage.2016.09.028
000140458 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2967/jnumed.115.161893$$o10.2967/jnumed.115.161893