TY  - JOUR
AU  - Sakr, Fatemah A
AU  - Grothe, Michel J
AU  - Cavedo, Enrica
AU  - Jelistratova, Irina
AU  - Habert, Marie-Odile
AU  - Dyrba, Martin
AU  - Gonzalez-Escamilla, Gabriel
AU  - Bertin, Hugo
AU  - Locatelli, Maxime
AU  - Lehericy, Stephane
AU  - Teipel, Stefan
AU  - Dubois, Bruno
AU  - Hampel, Harald
AU  - group, INSIGHT-preAD study
AU  - Initiative, Alzheimer Precision Medicine
AU  - Bakardjian, Hovagim
AU  - Benali, Habib
AU  - Bertin, Hugo
AU  - Bonheur, Joel
AU  - Boukadida, Laurie
AU  - Boukerrou, Nadia
AU  - Cavedo, Enrica
AU  - Chiesa, Patrizia
AU  - Colliot, Olivier
AU  - Dubois, Bruno
AU  - Dubois, Marion
AU  - Epelbaum, Stéphane
AU  - Gagliardi, Geoffroy
AU  - Genthon, Remy
AU  - Habert, Marie-Odile
AU  - Hampel, Harald
AU  - Houot, Marion
AU  - Kas, Aurélie
AU  - Lamari, Foudil
AU  - Levy, Marcel
AU  - Lista, Simone
AU  - Metzinger, Christiane
AU  - Mochel, Fanny
AU  - Nyasse, Francis
AU  - Poisson, Catherine
AU  - Potier, Marie-Claude
AU  - Revillon, Marie
AU  - Santos, Antonio
AU  - Andrade, Katia Santos
AU  - Sole, Marine
AU  - Surtee, Mohmed
AU  - de Schotten, Michel Thiebaud
AU  - Vergallo, Andrea
AU  - Younsi, Nadjia
TI  - Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study.
JO  - Alzheimer's research & therapy
VL  - 11
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DZNE-2020-06780
SP  - 15
PY  - 2019
AB  - Current methods of amyloid PET interpretation based on the binary classification of global amyloid signal fail to identify early phases of amyloid deposition. A recent analysis of 18F-florbetapir PET data from the Alzheimer's disease Neuroimaging Initiative cohort suggested a hierarchical four-stage model of regional amyloid deposition that resembles neuropathologic estimates and can be used to stage an individual's amyloid burden in vivo. Here, we evaluated the validity of this in vivo amyloid staging model in an independent cohort of older people with subjective memory complaints (SMC). We further examined its potential association with subtle cognitive impairments in this population at elevated risk for Alzheimer's disease (AD).The monocentric INSIGHT-preAD cohort includes 318 cognitively intact older individuals with SMC. All individuals underwent 18F-florbetapir PET scanning and extensive neuropsychological testing. We projected the regional amyloid uptake signal into the previously proposed hierarchical staging model of in vivo amyloid progression. We determined the adherence to this model across all cases and tested the association between increasing in vivo amyloid stage and cognitive performance using ANCOVA models.In total, 156 participants (49
KW  - Aged
KW  - Aged, 80 and over
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: metabolism
KW  - Alzheimer Disease: psychology
KW  - Amyloid: metabolism
KW  - Cognition: physiology
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: metabolism
KW  - Cognitive Dysfunction: psychology
KW  - Cohort Studies
KW  - Diagnostic Self Evaluation
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Male
KW  - Memory: physiology
KW  - Mental Status and Dementia Tests
LB  - PUB:(DE-HGF)16
C6  - pmid:30704537
C2  - pmc:PMC6357385
DO  - DOI:10.1186/s13195-019-0466-3
UR  - https://pub.dzne.de/record/140458
ER  -