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@ARTICLE{Sakr:140458,
      author       = {Sakr, Fatemah A and Grothe, Michel J and Cavedo, Enrica and
                      Jelistratova, Irina and Habert, Marie-Odile and Dyrba,
                      Martin and Gonzalez-Escamilla, Gabriel and Bertin, Hugo and
                      Locatelli, Maxime and Lehericy, Stephane and Teipel, Stefan
                      and Dubois, Bruno and Hampel, Harald and group,
                      INSIGHT-preAD study and Initiative, Alzheimer Precision
                      Medicine and Bakardjian, Hovagim and Benali, Habib and
                      Bertin, Hugo and Bonheur, Joel and Boukadida, Laurie and
                      Boukerrou, Nadia and Cavedo, Enrica and Chiesa, Patrizia and
                      Colliot, Olivier and Dubois, Bruno and Dubois, Marion and
                      Epelbaum, Stéphane and Gagliardi, Geoffroy and Genthon,
                      Remy and Habert, Marie-Odile and Hampel, Harald and Houot,
                      Marion and Kas, Aurélie and Lamari, Foudil and Levy, Marcel
                      and Lista, Simone and Metzinger, Christiane and Mochel,
                      Fanny and Nyasse, Francis and Poisson, Catherine and Potier,
                      Marie-Claude and Revillon, Marie and Santos, Antonio and
                      Andrade, Katia Santos and Sole, Marine and Surtee, Mohmed
                      and de Schotten, Michel Thiebaud and Vergallo, Andrea and
                      Younsi, Nadjia},
      title        = {{A}pplicability of in vivo staging of regional amyloid
                      burden in a cognitively normal cohort with subjective memory
                      complaints: the {INSIGHT}-pre{AD} study.},
      journal      = {Alzheimer's research $\&$ therapy},
      volume       = {11},
      number       = {1},
      issn         = {1758-9193},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2020-06780},
      pages        = {15},
      year         = {2019},
      abstract     = {Current methods of amyloid PET interpretation based on the
                      binary classification of global amyloid signal fail to
                      identify early phases of amyloid deposition. A recent
                      analysis of 18F-florbetapir PET data from the Alzheimer's
                      disease Neuroimaging Initiative cohort suggested a
                      hierarchical four-stage model of regional amyloid deposition
                      that resembles neuropathologic estimates and can be used to
                      stage an individual's amyloid burden in vivo. Here, we
                      evaluated the validity of this in vivo amyloid staging model
                      in an independent cohort of older people with subjective
                      memory complaints (SMC). We further examined its potential
                      association with subtle cognitive impairments in this
                      population at elevated risk for Alzheimer's disease (AD).The
                      monocentric INSIGHT-preAD cohort includes 318 cognitively
                      intact older individuals with SMC. All individuals underwent
                      18F-florbetapir PET scanning and extensive
                      neuropsychological testing. We projected the regional
                      amyloid uptake signal into the previously proposed
                      hierarchical staging model of in vivo amyloid progression.
                      We determined the adherence to this model across all cases
                      and tested the association between increasing in vivo
                      amyloid stage and cognitive performance using ANCOVA
                      models.In total, 156 participants $(49\%)$ showed evidence
                      of regional amyloid deposition, and all but 2 of these
                      $(99\%)$ adhered to the hierarchical regional pattern
                      implied by the in vivo amyloid progression model. According
                      to a conventional binary classification based on global
                      signal (SUVRCereb = 1.10), individuals in stages III and
                      IV were classified as amyloid-positive (except one in stage
                      III), but $99\%$ of individuals in stage I and even $28\%$
                      of individuals in stage II were classified as
                      amyloid-negative. Neither in vivo amyloid stage nor
                      conventional binary amyloid status was significantly
                      associated with cognitive performance in this preclinical
                      cohort.The proposed hierarchical staging scheme of
                      PET-evidenced amyloid deposition generalizes well to data
                      from an independent cohort of older people at elevated risk
                      for AD. Future studies will determine the prognostic value
                      of the staging approach for predicting longitudinal
                      cognitive decline in older individuals at increased risk for
                      AD.},
      keywords     = {Aged / Aged, 80 and over / Alzheimer Disease: diagnostic
                      imaging / Alzheimer Disease: metabolism / Alzheimer Disease:
                      psychology / Amyloid: metabolism / Cognition: physiology /
                      Cognitive Dysfunction: diagnostic imaging / Cognitive
                      Dysfunction: metabolism / Cognitive Dysfunction: psychology
                      / Cohort Studies / Diagnostic Self Evaluation / Female /
                      Follow-Up Studies / Humans / Male / Memory: physiology /
                      Mental Status and Dementia Tests},
      cin          = {AG Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30704537},
      pmc          = {pmc:PMC6357385},
      doi          = {10.1186/s13195-019-0466-3},
      url          = {https://pub.dzne.de/record/140458},
}