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@ARTICLE{Preische:140473,
      author       = {Preische, Oliver and Schultz, Stephanie A and Apel, Anja
                      and Kuhle, Jens and Kaeser, Stephan A and Barro, Christian
                      and Gräber, Susanne and Kuder-Buletta, Elke and la
                      Fougère, Christian and Laske, Christoph and Vöglein,
                      Jonathan and Levin, Johannes and Masters, Colin L and
                      Martins, Ralph and Schofield, Peter R and Rossor, Martin N
                      and Graff-Radford, Neill R and Salloway, Stephen and Ghetti,
                      Bernardino and Ringman, John M and Noble, James M and
                      Chhatwal, Jasmeer and Goate, Alison M and Benzinger, Tammie
                      L S and Morris, John C and Bateman, Randall J and Wang,
                      Guoqiao and Fagan, Anne M and McDade, Eric M and Gordon,
                      Brian A and Jucker, Mathias and Network, Dominantly
                      Inherited Alzheimer and Allegri, Ricardo and Amtashar,
                      Fatima and Bateman, Randall and Benzinger, Tammie and
                      Berman, Sarah and Bodge, Courtney and Brandon, Susan and
                      Brooks, William and Buck, Jill and Buckles, Virginia and
                      Chea, Sochenda and Chhatwal, Jasmeer and Chrem, Patricio and
                      Chui, Helena and Cinco, Jake and Clifford, Jack and
                      Cruchaga, Carlos and D'Mello, Mirelle and Donahue, Tamara
                      and Douglas, Jane and Edigo, Noelia and Erekin-Taner,
                      Nilufer and Fagan, Anne and Farlow, Marty and Farrar, Angela
                      and Feldman, Howard and Flynn, Gigi and Fox, Nick and
                      Franklin, Erin and Fujii, Hisako and Gant, Cortaiga and
                      Gardener, Samantha and Ghetti, Bernardino and Goate, Alison
                      and Goldman, Jill and Gordon, Brian and Graff-Radford, Neill
                      and Gray, Julia and Gurney, Jenny and Hassenstab, Jason and
                      Hirohara, Mie and Holtzman, David and Hornbeck, Russ and
                      DiBari, Siri Houeland and Ikeuchi, Takeshi and Ikonomovic,
                      Snezana and Jerome, Gina and Karch, Celeste and Kasuga,
                      Kensaku and Kawarabayashi, Takeshi and Klunk, William and
                      Koeppe, Robert and Kuder-Buletta, Elke and Lee, Jae-Hong and
                      Marcus, Daniel and Martins, Ralph and Mason, Neal Scott and
                      Masters, Colin and Maue-Dreyfus, Denise and McDade, Eric and
                      Montoya, Lucy and Mori, Hiroshi and Morris, John and
                      Nagamatsu, Akem and Neimeyer, Katie and Noble, James and
                      Norton, Joanne and Perrin, Richard and Raichle, Marc and
                      Ringman, John and Roh, Jee Hoon and Salloway, Stephen and
                      Schofield, Peter and Shimada, Hiroyuki and Shiroto, Tomoyo
                      and Shoji, Mikio and Sigurdson, Wendy and Sohrabi, Hamid and
                      Sparks, Paige and Suzuki, Kazushi and Swisher, Laura and
                      Taddei, Kevin and Wang, Jen and Wang, Peter and Weiner, Mike
                      and Wolfsberger, Mary and Xiong, Chengjie and Xu, Xiong},
      title        = {{S}erum neurofilament dynamics predicts neurodegeneration
                      and clinical progression in presymptomatic {A}lzheimer's
                      disease.},
      journal      = {Nature medicine},
      volume       = {25},
      number       = {2},
      issn         = {1078-8956},
      address      = {New York, NY},
      publisher    = {Nature America Inc.},
      reportid     = {DZNE-2020-06795},
      pages        = {277-283},
      year         = {2019},
      abstract     = {Neurofilament light chain (NfL) is a promising fluid
                      biomarker of disease progression for various cerebral
                      proteopathies. Here we leverage the unique characteristics
                      of the Dominantly Inherited Alzheimer Network and
                      ultrasensitive immunoassay technology to demonstrate that
                      NfL levels in the cerebrospinal fluid (n = 187) and
                      serum (n = 405) are correlated with one another and are
                      elevated at the presymptomatic stages of familial
                      Alzheimer's disease. Longitudinal, within-person analysis of
                      serum NfL dynamics (n = 196) confirmed this elevation
                      and further revealed that the rate of change of serum NfL
                      could discriminate mutation carriers from non-mutation
                      carriers almost a decade earlier than cross-sectional
                      absolute NfL levels (that is, 16.2 versus 6.8 years before
                      the estimated symptom onset). Serum NfL rate of change
                      peaked in participants converting from the presymptomatic to
                      the symptomatic stage and was associated with cortical
                      thinning assessed by magnetic resonance imaging, but less so
                      with amyloid-β deposition or glucose metabolism (assessed
                      by positron emission tomography). Serum NfL was predictive
                      for both the rate of cortical thinning and cognitive changes
                      assessed by the Mini-Mental State Examination and Logical
                      Memory test. Thus, NfL dynamics in serum predict disease
                      progression and brain neurodegeneration at the early
                      presymptomatic stages of familial Alzheimer's disease, which
                      supports its potential utility as a clinically useful
                      biomarker.},
      subtyp        = {Letter},
      keywords     = {Alzheimer Disease: blood / Alzheimer Disease: cerebrospinal
                      fluid / Alzheimer Disease: pathology / Disease Progression /
                      Humans / Mutation: genetics / Nerve Degeneration: blood /
                      Neurofilament Proteins: blood / Neurofilament Proteins:
                      cerebrospinal fluid / Neurofilament Proteins: genetics /
                      Neurofilament Proteins (NLM Chemicals) / neurofilament
                      protein L (NLM Chemicals)},
      cin          = {AG Jucker / Core ICRU / Tübingen common / AG Höglinger 1
                      / Clinical Research (Munich) / AG Levin},
      ddc          = {610},
      cid          = {I:(DE-2719)1210001 / I:(DE-2719)1240005 /
                      I:(DE-2719)6000018 / I:(DE-2719)1110002 / I:(DE-2719)1111015
                      / I:(DE-2719)1111016},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 344
                      - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30664784},
      pmc          = {pmc:PMC6367005},
      doi          = {10.1038/s41591-018-0304-3},
      url          = {https://pub.dzne.de/record/140473},
}