000140482 001__ 140482
000140482 005__ 20240321220822.0
000140482 0247_ $$2doi$$a10.15252/emmm.201809665
000140482 0247_ $$2pmid$$apmid:30617153
000140482 0247_ $$2pmc$$apmc:PMC6365929
000140482 0247_ $$2ISSN$$a1715-4684
000140482 0247_ $$2ISSN$$a1757-4676
000140482 0247_ $$2ISSN$$a1757-4684
000140482 0247_ $$2altmetric$$aaltmetric:53595424
000140482 037__ $$aDZNE-2020-06804
000140482 041__ $$aEnglish
000140482 082__ $$a610
000140482 1001_ $$0P:(DE-2719)2811281$$aReichenbach, Nicole$$b0$$eFirst author
000140482 245__ $$aInhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model.
000140482 260__ $$aHeidelberg$$bEMBO Press$$c2019
000140482 264_1 $$2Crossref$$3online$$bEMBO$$c2019-01-07
000140482 264_1 $$2Crossref$$3print$$bEMBO$$c2019-02-01
000140482 3367_ $$2DRIVER$$aarticle
000140482 3367_ $$2DataCite$$aOutput Types/Journal article
000140482 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1708432762_6808
000140482 3367_ $$2BibTeX$$aARTICLE
000140482 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000140482 3367_ $$00$$2EndNote$$aJournal Article
000140482 520__ $$aReactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood. We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis, is activated in an AD mouse model and human AD Therefore, using a conditional knockout approach, we deleted Stat3 specifically in astrocytes in the APP/PS1 model of AD We found that Stat3-deficient APP/PS1 mice show decreased β-amyloid levels and plaque burden. Plaque-close microglia displayed a more complex morphology, internalized more β-amyloid, and upregulated amyloid clearance pathways in Stat3-deficient mice. Moreover, astrocyte-specific Stat3-deficient APP/PS1 mice showed decreased pro-inflammatory cytokine activation and lower dystrophic neurite burden, and were largely protected from cerebral network imbalance. Finally, Stat3 deletion in astrocytes also strongly ameliorated spatial learning and memory decline in APP/PS1 mice. Importantly, these protective effects on network dysfunction and cognition were recapitulated in APP/PS1 mice systemically treated with a preclinical Stat3 inhibitor drug. In summary, our data implicate Stat3-mediated astrogliosis as an important therapeutic target in AD.
000140482 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000140482 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x1
000140482 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x2
000140482 542__ $$2Crossref$$i2019-01-07$$uhttp://creativecommons.org/licenses/by/4.0/
000140482 542__ $$2Crossref$$i2019-01-07$$uhttp://doi.wiley.com/10.1002/tdm_license_1.1
000140482 588__ $$aDataset connected to CrossRef, PubMed,
000140482 650_7 $$2NLM Chemicals$$aSTAT3 Transcription Factor
000140482 650_7 $$2NLM Chemicals$$aSTAT3 protein, human
000140482 650_7 $$2NLM Chemicals$$aStat3 protein, mouse
000140482 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000140482 650_2 $$2MeSH$$aAnimals
000140482 650_2 $$2MeSH$$aAstrocytes: pathology
000140482 650_2 $$2MeSH$$aCell Proliferation
000140482 650_2 $$2MeSH$$aDisease Models, Animal
000140482 650_2 $$2MeSH$$aGene Knockout Techniques
000140482 650_2 $$2MeSH$$aHumans
000140482 650_2 $$2MeSH$$aMice
000140482 650_2 $$2MeSH$$aMice, Knockout
000140482 650_2 $$2MeSH$$aSTAT3 Transcription Factor: analysis
000140482 650_2 $$2MeSH$$aSTAT3 Transcription Factor: deficiency
000140482 7001_ $$0P:(DE-2719)2810454$$aDelekate, Andrea$$b1
000140482 7001_ $$0P:(DE-2719)2812070$$aPlescher, Monika$$b2
000140482 7001_ $$0P:(DE-2719)2812206$$aSchmitt, Franziska$$b3
000140482 7001_ $$0P:(DE-2719)2421562$$aKrauß, Sybille$$b4
000140482 7001_ $$0P:(DE-2719)2811722$$aBlank, Nelli$$b5
000140482 7001_ $$0P:(DE-2719)2812038$$aHalle, Annett$$b6
000140482 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b7$$eLast author
000140482 77318 $$2Crossref$$3journal-article$$a10.15252/emmm.201809665$$b : EMBO, 2019-01-07$$n2$$tEMBO Molecular Medicine$$v11$$x1757-4676$$y2019
000140482 773__ $$0PERI:(DE-600)2485479-7$$a10.15252/emmm.201809665$$gVol. 11, no. 2$$n2$$pe9665$$q11:2$$tEMBO molecular medicine$$v11$$x1757-4676$$y2019
000140482 8564_ $$uhttps://pub.dzne.de/record/140482/files/DZNE-2020-06804.pdf$$yOpenAccess
000140482 8564_ $$uhttps://pub.dzne.de/record/140482/files/DZNE-2020-06804.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000140482 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365929
000140482 909CO $$ooai:pub.dzne.de:140482$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000140482 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811281$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000140482 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810454$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000140482 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812070$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000140482 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812206$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000140482 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2421562$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000140482 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811722$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000140482 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812038$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000140482 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810273$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000140482 9131_ $$0G:(DE-HGF)POF3-341$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vMolecular Signaling$$x0
000140482 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x1
000140482 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x2
000140482 9141_ $$y2019
000140482 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-29
000140482 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-29
000140482 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000140482 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEMBO MOL MED : 2021$$d2022-11-29
000140482 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-07-19T13:19:31Z
000140482 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-07-19T13:19:31Z
000140482 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bEMBO MOL MED : 2021$$d2022-11-29
000140482 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-29
000140482 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000140482 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review, Double blind peer review$$d2021-07-19T13:19:31Z
000140482 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-29
000140482 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-29
000140482 9201_ $$0I:(DE-2719)1013020$$kAG Petzold ; AG Petzold$$lVascular Neurology$$x0
000140482 9201_ $$0I:(DE-2719)1013003$$kAG Bano$$lAging and Neurodegeneration$$x1
000140482 9201_ $$0I:(DE-2719)1011006$$kAG Krauß$$lRegulatory RNA-protein interaction in neurodegenerative diseases$$x2
000140482 9201_ $$0I:(DE-2719)1013034$$kAG Halle$$lMicroglia and Neuroinflammation$$x3
000140482 980__ $$ajournal
000140482 980__ $$aVDB
000140482 980__ $$aUNRESTRICTED
000140482 980__ $$aI:(DE-2719)1013020
000140482 980__ $$aI:(DE-2719)1013003
000140482 980__ $$aI:(DE-2719)1011006
000140482 980__ $$aI:(DE-2719)1013034
000140482 9801_ $$aFullTexts
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1128/MCB.21.5.1621-1632.2001$$o10.1128/MCB.21.5.1621-1632.2001
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2008.10.013$$o10.1016/j.neuron.2008.10.013
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.3516-14.2015$$o10.1523/JNEUROSCI.3516-14.2015
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2013.12.034$$o10.1016/j.neuron.2013.12.034
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2967/jnumed.110.087031$$o10.2967/jnumed.110.087031
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/s40478-018-0606-1$$o10.1186/s40478-018-0606-1
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncomms7176$$o10.1038/ncomms7176
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncomms6422$$o10.1038/ncomms6422
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.yjmcc.2003.10.006$$o10.1016/j.yjmcc.2003.10.006
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3758/BF03193146$$o10.3758/BF03193146
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/ml4003138$$o10.1021/ml4003138
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1474-4422(15)70016-5$$o10.1016/S1474-4422(15)70016-5
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.1709-08.2008$$o10.1523/JNEUROSCI.1709-08.2008
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/jnc.13490$$o10.1111/jnc.13490
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/hmg/ddh019$$o10.1093/hmg/ddh019
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/(SICI)1098-1136(200005)30:3<253::AID-GLIA5>3.0.CO;2-O$$o10.1002/(SICI)1098-1136(200005)30:3<253::AID-GLIA5>3.0.CO;2-O
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1300378110$$o10.1073/pnas.1300378110
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature21029$$o10.1038/nature21029
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2018.10.031$$o10.1016/j.neuron.2018.10.031
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nm1425$$o10.1038/nm1425
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.2535$$o10.1038/nn.2535
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrn.2016.141$$o10.1038/nrn.2016.141
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1182/blood-2006-02-003012$$o10.1182/blood-2006-02-003012
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1152/physrev.00041.2013$$o10.1152/physrev.00041.2013
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00401-015-1513-1$$o10.1007/s00401-015-1513-1
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1117218109$$o10.1073/pnas.1117218109
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI89354$$o10.1172/JCI89354
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1084/jem.20171487$$o10.1084/jem.20171487
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/s41586-018-0119-x$$o10.1038/s41586-018-0119-x
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2012.03.026$$o10.1016/j.neuron.2012.03.026
000140482 999C5 $$2Crossref$$oSchafer DP 2014$$y2014
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/scitranslmed.aaf6295$$o10.1126/scitranslmed.aaf6295
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.3691$$o10.1038/nn.3691
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/s41467-017-01283-z$$o10.1038/s41467-017-01283-z
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1474-4422(10)70325-2$$o10.1016/S1474-4422(10)70325-2
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ni.3691$$o10.1038/ni.3691
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nprot.2006.116$$o10.1038/nprot.2006.116
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s12264-018-0262-2$$o10.1007/s12264-018-0262-2
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroscience.2006.06.034$$o10.1016/j.neuroscience.2006.06.034
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s11064-011-0576-1$$o10.1007/s11064-011-0576-1
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/s41591-018-0051-5$$o10.1038/s41591-018-0051-5
000140482 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.6221-11.2012$$o10.1523/JNEUROSCI.6221-11.2012