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| Home > Publications Database > Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model. > print |
| 001 | 140482 | ||
| 005 | 20240321220822.0 | ||
| 024 | 7 | _ | |a 10.15252/emmm.201809665 |2 doi |
| 024 | 7 | _ | |a pmid:30617153 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6365929 |2 pmc |
| 024 | 7 | _ | |a 1715-4684 |2 ISSN |
| 024 | 7 | _ | |a 1757-4676 |2 ISSN |
| 024 | 7 | _ | |a 1757-4684 |2 ISSN |
| 024 | 7 | _ | |a altmetric:53595424 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06804 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Reichenbach, Nicole |0 P:(DE-2719)2811281 |b 0 |e First author |
| 245 | _ | _ | |a Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model. |
| 260 | _ | _ | |a Heidelberg |c 2019 |b EMBO Press |
| 264 | _ | 1 | |3 online |2 Crossref |b EMBO |c 2019-01-07 |
| 264 | _ | 1 | |3 print |2 Crossref |b EMBO |c 2019-02-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1708432762_6808 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood. We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis, is activated in an AD mouse model and human AD Therefore, using a conditional knockout approach, we deleted Stat3 specifically in astrocytes in the APP/PS1 model of AD We found that Stat3-deficient APP/PS1 mice show decreased β-amyloid levels and plaque burden. Plaque-close microglia displayed a more complex morphology, internalized more β-amyloid, and upregulated amyloid clearance pathways in Stat3-deficient mice. Moreover, astrocyte-specific Stat3-deficient APP/PS1 mice showed decreased pro-inflammatory cytokine activation and lower dystrophic neurite burden, and were largely protected from cerebral network imbalance. Finally, Stat3 deletion in astrocytes also strongly ameliorated spatial learning and memory decline in APP/PS1 mice. Importantly, these protective effects on network dysfunction and cognition were recapitulated in APP/PS1 mice systemically treated with a preclinical Stat3 inhibitor drug. In summary, our data implicate Stat3-mediated astrogliosis as an important therapeutic target in AD. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 1 |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 2 |
| 542 | _ | _ | |i 2019-01-07 |2 Crossref |u http://creativecommons.org/licenses/by/4.0/ |
| 542 | _ | _ | |i 2019-01-07 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a STAT3 Transcription Factor |2 NLM Chemicals |
| 650 | _ | 7 | |a STAT3 protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Stat3 protein, mouse |2 NLM Chemicals |
| 650 | _ | 2 | |a Alzheimer Disease: pathology |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Astrocytes: pathology |2 MeSH |
| 650 | _ | 2 | |a Cell Proliferation |2 MeSH |
| 650 | _ | 2 | |a Disease Models, Animal |2 MeSH |
| 650 | _ | 2 | |a Gene Knockout Techniques |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Knockout |2 MeSH |
| 650 | _ | 2 | |a STAT3 Transcription Factor: analysis |2 MeSH |
| 650 | _ | 2 | |a STAT3 Transcription Factor: deficiency |2 MeSH |
| 700 | 1 | _ | |a Delekate, Andrea |0 P:(DE-2719)2810454 |b 1 |
| 700 | 1 | _ | |a Plescher, Monika |0 P:(DE-2719)2812070 |b 2 |
| 700 | 1 | _ | |a Schmitt, Franziska |0 P:(DE-2719)2812206 |b 3 |
| 700 | 1 | _ | |a Krauß, Sybille |0 P:(DE-2719)2421562 |b 4 |
| 700 | 1 | _ | |a Blank, Nelli |0 P:(DE-2719)2811722 |b 5 |
| 700 | 1 | _ | |a Halle, Annett |0 P:(DE-2719)2812038 |b 6 |
| 700 | 1 | _ | |a Petzold, Gabor C |0 P:(DE-2719)2810273 |b 7 |e Last author |
| 773 | 1 | 8 | |a 10.15252/emmm.201809665 |b : EMBO, 2019-01-07 |n 2 |3 journal-article |2 Crossref |t EMBO Molecular Medicine |v 11 |y 2019 |x 1757-4676 |
| 773 | _ | _ | |a 10.15252/emmm.201809665 |g Vol. 11, no. 2 |0 PERI:(DE-600)2485479-7 |n 2 |q 11:2 |p e9665 |t EMBO molecular medicine |v 11 |y 2019 |x 1757-4676 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/140482/files/DZNE-2020-06804.pdf |
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| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365929 |
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| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1128/MCB.21.5.1621-1632.2001 |2 Crossref |o 10.1128/MCB.21.5.1621-1632.2001 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2008.10.013 |2 Crossref |o 10.1016/j.neuron.2008.10.013 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.3516-14.2015 |2 Crossref |o 10.1523/JNEUROSCI.3516-14.2015 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2013.12.034 |2 Crossref |o 10.1016/j.neuron.2013.12.034 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.2967/jnumed.110.087031 |2 Crossref |o 10.2967/jnumed.110.087031 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1186/s40478-018-0606-1 |2 Crossref |o 10.1186/s40478-018-0606-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ncomms7176 |2 Crossref |o 10.1038/ncomms7176 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ncomms6422 |2 Crossref |o 10.1038/ncomms6422 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.yjmcc.2003.10.006 |2 Crossref |o 10.1016/j.yjmcc.2003.10.006 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3758/BF03193146 |2 Crossref |o 10.3758/BF03193146 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1021/ml4003138 |2 Crossref |o 10.1021/ml4003138 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S1474-4422(15)70016-5 |2 Crossref |o 10.1016/S1474-4422(15)70016-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.1709-08.2008 |2 Crossref |o 10.1523/JNEUROSCI.1709-08.2008 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/jnc.13490 |2 Crossref |o 10.1111/jnc.13490 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/hmg/ddh019 |2 Crossref |o 10.1093/hmg/ddh019 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/(SICI)1098-1136(200005)30:3<253::AID-GLIA5>3.0.CO;2-O |2 Crossref |o 10.1002/(SICI)1098-1136(200005)30:3<253::AID-GLIA5>3.0.CO;2-O |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1300378110 |2 Crossref |o 10.1073/pnas.1300378110 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature21029 |2 Crossref |o 10.1038/nature21029 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2018.10.031 |2 Crossref |o 10.1016/j.neuron.2018.10.031 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nm1425 |2 Crossref |o 10.1038/nm1425 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn.2535 |2 Crossref |o 10.1038/nn.2535 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrn.2016.141 |2 Crossref |o 10.1038/nrn.2016.141 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1182/blood-2006-02-003012 |2 Crossref |o 10.1182/blood-2006-02-003012 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1152/physrev.00041.2013 |2 Crossref |o 10.1152/physrev.00041.2013 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00401-015-1513-1 |2 Crossref |o 10.1007/s00401-015-1513-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1117218109 |2 Crossref |o 10.1073/pnas.1117218109 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1172/JCI89354 |2 Crossref |o 10.1172/JCI89354 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1084/jem.20171487 |2 Crossref |o 10.1084/jem.20171487 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41586-018-0119-x |2 Crossref |o 10.1038/s41586-018-0119-x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2012.03.026 |2 Crossref |o 10.1016/j.neuron.2012.03.026 |
| 999 | C | 5 | |y 2014 |2 Crossref |o Schafer DP 2014 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1126/scitranslmed.aaf6295 |2 Crossref |o 10.1126/scitranslmed.aaf6295 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nn.3691 |2 Crossref |o 10.1038/nn.3691 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41467-017-01283-z |2 Crossref |o 10.1038/s41467-017-01283-z |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S1474-4422(10)70325-2 |2 Crossref |o 10.1016/S1474-4422(10)70325-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/ni.3691 |2 Crossref |o 10.1038/ni.3691 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nprot.2006.116 |2 Crossref |o 10.1038/nprot.2006.116 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s12264-018-0262-2 |2 Crossref |o 10.1007/s12264-018-0262-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuroscience.2006.06.034 |2 Crossref |o 10.1016/j.neuroscience.2006.06.034 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s11064-011-0576-1 |2 Crossref |o 10.1007/s11064-011-0576-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/s41591-018-0051-5 |2 Crossref |o 10.1038/s41591-018-0051-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.6221-11.2012 |2 Crossref |o 10.1523/JNEUROSCI.6221-11.2012 |
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