TY  - JOUR
AU  - Bedarf, Janis
AU  - Hildebrand, F.
AU  - Goeser, F.
AU  - Bork, P.
AU  - Wüllner, U.
TI  - The gut microbiome in Parkinson's disease  -  Das Darmmikrobiom bei der Parkinson-Krankheit
JO  - Der Nervenarzt
VL  - 90
IS  - 2
SN  - 0028-2804
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2020-06810
SP  - 160-166
PY  - 2019
AB  - The vast majority of Parkinson's disease (PD) cases are of sporadic origin and despite extensive research in recent years, the etiology still remains unclear. Several current case control studies are aiming to characterize a putative PD-specific composition of the gut microbiome, reflecting the potential relevance of microbiota in the pathogenesis of PD. Although methodologies and cohort sizes differed, the currently available studies showed reproducible or consistent results in terms of PD-specific alterations to the intestinal bacteria. By applying metagenomic sequencing procedures, it is even possible to distinguish PD cases from healthy individuals at a very early disease stage by means of individually modified microbiota. Among others, microbiota that are associated with an altered intestinal barrier or immune function, such as Akkermansia, Lactobacillus, Faecalibacterium and Prevotella were significantly over-represented or under-represented. There may even be a prodromal microbiome, as a comparable microbial shift is also found in patients with rapid eye movement (REM) sleep behavior disorder (RBD), a risk factor for the later development of synucleinopathies, such as PD.
KW  - Case-Control Studies
KW  - Gastrointestinal Microbiome
KW  - Humans
KW  - Metagenome
KW  - Parkinson Disease: diagnosis
KW  - Parkinson Disease: microbiology
KW  - REM Sleep Behavior Disorder: microbiology
LB  - PUB:(DE-HGF)16
C6  - pmid:30171304
DO  - DOI:10.1007/s00115-018-0601-6
UR  - https://pub.dzne.de/record/140488
ER  -