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@ARTICLE{Bedarf:140488,
      author       = {Bedarf, Janis and Hildebrand, F. and Goeser, F. and Bork,
                      P. and Wüllner, U.},
      title        = {{T}he gut microbiome in {P}arkinson's disease | {D}as
                      {D}armmikrobiom bei der {P}arkinson-{K}rankheit},
      journal      = {Der Nervenarzt},
      volume       = {90},
      number       = {2},
      issn         = {0028-2804},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2020-06810},
      pages        = {160-166},
      year         = {2019},
      abstract     = {The vast majority of Parkinson's disease (PD) cases are of
                      sporadic origin and despite extensive research in recent
                      years, the etiology still remains unclear. Several current
                      case control studies are aiming to characterize a putative
                      PD-specific composition of the gut microbiome, reflecting
                      the potential relevance of microbiota in the pathogenesis of
                      PD. Although methodologies and cohort sizes differed, the
                      currently available studies showed reproducible or
                      consistent results in terms of PD-specific alterations to
                      the intestinal bacteria. By applying metagenomic sequencing
                      procedures, it is even possible to distinguish PD cases from
                      healthy individuals at a very early disease stage by means
                      of individually modified microbiota. Among others,
                      microbiota that are associated with an altered intestinal
                      barrier or immune function, such as Akkermansia,
                      Lactobacillus, Faecalibacterium and Prevotella were
                      significantly over-represented or under-represented. There
                      may even be a prodromal microbiome, as a comparable
                      microbial shift is also found in patients with rapid eye
                      movement (REM) sleep behavior disorder (RBD), a risk factor
                      for the later development of synucleinopathies, such as PD.},
      subtyp        = {Review Article},
      keywords     = {Case-Control Studies / Gastrointestinal Microbiome / Humans
                      / Metagenome / Parkinson Disease: diagnosis / Parkinson
                      Disease: microbiology / REM Sleep Behavior Disorder:
                      microbiology},
      cin          = {AG Tamgüney 2 / AG Wüllner},
      ddc          = {610},
      cid          = {I:(DE-2719)1013022 / I:(DE-2719)1011302},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 344
                      - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30171304},
      doi          = {10.1007/s00115-018-0601-6},
      url          = {https://pub.dzne.de/record/140488},
}