%0 Journal Article
%A Hobert, Markus A
%A Nussbaum, Susanne
%A Heger, Tanja
%A Berg, Daniela
%A Maetzler, Walter
%A Heinzel, Sebastian
%T Progressive Gait Deficits in Parkinson's Disease: A Wearable-Based Biannual 5-Year Prospective Study.
%J Frontiers in aging neuroscience
%V 11
%@ 1663-4365
%C Lausanne
%I Frontiers Research Foundation
%M DZNE-2020-06811
%P 22
%D 2019
%X Background: Gait changes occur during all Parkinson’s disease (PD) stages and wearable sensor-derived gait parameters may quantify PD progression. However, key aspects that may qualify quantitative gait parameters as progression markers in PD remain elusive.Objectives: Longitudinal changes in gait parameters from a lower-back sensor under convenient and challenging walking conditions in early- and mid-stage PD patients (E-PD, M-PD) compared to controls were investigated.Methods: Normal- and fast-pace parameters (step: number, time, velocity, variability) were assessed every 6 months for up to 5 years in 22 E-PD (<4 years baseline disease duration), 18 M-PD (>5 years) and 24 controls. Parameter trajectories and associations with MDS-UPDRS-III were tested using generalized estimating equations.Results: Normal-pace step number (annual change in E-PD: 2.1
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30814947
%2 pmc:PMC6381067
%R 10.3389/fnagi.2019.00022
%U https://pub.dzne.de/record/140489