TY  - JOUR
AU  - Hobert, Markus A
AU  - Nussbaum, Susanne
AU  - Heger, Tanja
AU  - Berg, Daniela
AU  - Maetzler, Walter
AU  - Heinzel, Sebastian
TI  - Progressive Gait Deficits in Parkinson's Disease: A Wearable-Based Biannual 5-Year Prospective Study.
JO  - Frontiers in aging neuroscience
VL  - 11
SN  - 1663-4365
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DZNE-2020-06811
SP  - 22
PY  - 2019
AB  - Background: Gait changes occur during all Parkinson’s disease (PD) stages and wearable sensor-derived gait parameters may quantify PD progression. However, key aspects that may qualify quantitative gait parameters as progression markers in PD remain elusive.Objectives: Longitudinal changes in gait parameters from a lower-back sensor under convenient and challenging walking conditions in early- and mid-stage PD patients (E-PD, M-PD) compared to controls were investigated.Methods: Normal- and fast-pace parameters (step: number, time, velocity, variability) were assessed every 6 months for up to 5 years in 22 E-PD (<4 years baseline disease duration), 18 M-PD (>5 years) and 24 controls. Parameter trajectories and associations with MDS-UPDRS-III were tested using generalized estimating equations.Results: Normal-pace step number (annual change in E-PD: 2.1
LB  - PUB:(DE-HGF)16
C6  - pmid:30814947
C2  - pmc:PMC6381067
DO  - DOI:10.3389/fnagi.2019.00022
UR  - https://pub.dzne.de/record/140489
ER  -