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| 001 | 140489 | ||
| 005 | 20240321220823.0 | ||
| 024 | 7 | _ | |a 10.3389/fnagi.2019.00022 |2 doi |
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| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Hobert, Markus A |0 P:(DE-2719)9000133 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Progressive Gait Deficits in Parkinson's Disease: A Wearable-Based Biannual 5-Year Prospective Study. |
| 260 | _ | _ | |a Lausanne |c 2019 |b Frontiers Research Foundation |
| 264 | _ | 1 | |3 online |2 Crossref |b Frontiers Media SA |c 2019-02-13 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1604064935_31612 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Background: Gait changes occur during all Parkinson’s disease (PD) stages and wearable sensor-derived gait parameters may quantify PD progression. However, key aspects that may qualify quantitative gait parameters as progression markers in PD remain elusive.Objectives: Longitudinal changes in gait parameters from a lower-back sensor under convenient and challenging walking conditions in early- and mid-stage PD patients (E-PD, M-PD) compared to controls were investigated.Methods: Normal- and fast-pace parameters (step: number, time, velocity, variability) were assessed every 6 months for up to 5 years in 22 E-PD (<4 years baseline disease duration), 18 M-PD (>5 years) and 24 controls. Parameter trajectories and associations with MDS-UPDRS-III were tested using generalized estimating equations.Results: Normal-pace step number (annual change in E-PD: 2.1%, Time∗Group: p = 0.001) and step time variability (8.5%, p < 0.05) longitudinally increased in E-PD compared to controls (0.7%, -12%). For fast pace, no significant progression differences between groups were observed. Longitudinal changes in M-PD did not differ significantly from controls. MDS-UPDRS-III was largely associated with normal-pace parameters in M-PD.Conclusion: Wearables can quantify progressive gait deficits indicated by increasing step number and step time variability in E-PD. In M-PD, and for fast-pace, gait parameters possess limited potential as PD progression markers. |
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| 542 | _ | _ | |i 2019-02-13 |2 Crossref |u https://creativecommons.org/licenses/by/4.0/ |
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| 700 | 1 | _ | |a Nussbaum, Susanne |0 P:(DE-2719)2810733 |b 1 |u dzne |
| 700 | 1 | _ | |a Heger, Tanja |0 P:(DE-2719)9000123 |b 2 |u dzne |
| 700 | 1 | _ | |a Berg, Daniela |0 P:(DE-2719)2000059 |b 3 |u dzne |
| 700 | 1 | _ | |a Maetzler, Walter |0 P:(DE-2719)2810915 |b 4 |u dzne |
| 700 | 1 | _ | |a Heinzel, Sebastian |0 P:(DE-HGF)0 |b 5 |e Corresponding author |
| 773 | 1 | 8 | |a 10.3389/fnagi.2019.00022 |b : Frontiers Media SA, 2019-02-13 |3 journal-article |2 Crossref |t Frontiers in Aging Neuroscience |v 11 |y 2019 |x 1663-4365 |
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| 856 | 4 | _ | |u https://www.frontiersin.org/articles/10.3389/fnagi.2019.00022/full |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381067 |
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