TY  - JOUR
AU  - Schüller, Canan Beate
AU  - Kuhn, Jens
AU  - Jessen, Frank
AU  - Hu, Xiaochen
TI  - Neuronal correlates of delay discounting in healthy subjects and its implication for addiction: an ALE meta-analysis study.
JO  - The American journal of drug and alcohol abuse
VL  - 45
IS  - 1
SN  - 0095-2990
CY  - Abingdon
PB  - Taylor & Francis Group
M1  - DZNE-2020-06820
SP  - 51-66
PY  - 2019
AB  - Delay discounting (DD) describes the phenomenon of devaluing future rewards in favor of immediate rewards. Increased DD is a key behavioral marker of addiction, and has been suggested as a target for interventions to alleviate addiction symptoms (e.g., preference for immediate drug use over larger-and-later rewards, and relapses) in patients with substance use disorders (SUD).Performed a meta-analysis on neuroimaging results of DD regarding specific contrasts in healthy participants. Reviewed the results of existing patient studies in light of the meta-analyses results.We conducted activation likelihood estimation meta-analyses on DD neuroimaging studies (25 studies, n = 583; 354 males and 229 females) regarding six analytic strategies.The meta-analyses revealed various subdivisions of the cortical-basal ganglia circuits that are associated with different aspects of DD in healthy subjects. By comparing the meta-analyses results and patients' studies regarding each contrast, we highlighted three brain regions that may underlie excessive DD in patients. Decreased left inferior frontal gyrus (IFG) activity was related to less preference for delayed choices; reduced ventral striatum (VS) activity was associated with impaired valuation processes; and declined anterior cingulate cortex (ACC)/medial prefrontal cortex (mPFC) activity was associated with alterations in processing difficult choices.We propose that neuromodulation (e.g. deep brain simulation) or behavioral interventions (e.g. episodic future imagination) targeting these key brain regions (IFG, VS, ACC/mPFC) may be effective for improving DD function in patients with SUD, enhancing valuations of future rewards and helping to resist the temptation of immediate drug use.
KW  - Brain: diagnostic imaging
KW  - Choice Behavior: physiology
KW  - Delay Discounting: physiology
KW  - Female
KW  - Healthy Volunteers
KW  - Humans
KW  - Male
KW  - Neuroimaging: methods
KW  - Reward
KW  - Substance-Related Disorders: diagnostic imaging
LB  - PUB:(DE-HGF)16
C6  - pmid:30632802
DO  - DOI:10.1080/00952990.2018.1557675
UR  - https://pub.dzne.de/record/140498
ER  -