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@ARTICLE{Vglein:140511,
      author       = {Vöglein, Jonathan and Noachtar, Soheyl and McDade, Eric
                      and Quaid, Kimberly A and Salloway, Stephen and Ghetti,
                      Bernardino and Noble, James and Berman, Sarah and Chhatwal,
                      Jasmeer and Mori, Hiroshi and Fox, Nick and Allegri, Ricardo
                      and Masters, Colin L and Buckles, Virginia and Ringman, John
                      M and Rossor, Martin and Schofield, Peter R and Sperling,
                      Reisa and Jucker, Mathias and Laske, Christoph and Paumier,
                      Katrina and Morris, John C and Bateman, Randall J and Levin,
                      Johannes and Danek, Adrian and Network, Dominantly Inherited
                      Alzheimer},
      title        = {{S}eizures as an early symptom of autosomal dominant
                      {A}lzheimer's disease.},
      journal      = {Neurobiology of aging},
      volume       = {76},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-06833},
      pages        = {18-23},
      year         = {2019},
      abstract     = {Our objective was to assess the reported history of
                      seizures in cognitively asymptomatic mutation carriers for
                      autosomal dominant Alzheimer's disease (ADAD) and the
                      predictive value of seizures for mutation carrier status in
                      cognitively asymptomatic first-degree relatives of ADAD
                      patients. Seizure occurrence in the Dominantly Inherited
                      Alzheimer Network observational study was correlated with
                      mutation carrier status in cognitively asymptomatic
                      subjects. Of 276 cognitively asymptomatic individuals, 11
                      $(4\%)$ had experienced seizures, and nine of these carried
                      an ADAD mutation. Thus, in the Dominantly Inherited
                      Alzheimer Network population, seizure frequency in mutation
                      carriers was significantly higher than in noncarriers (p =
                      0.04), and the positive predictive value of seizures for the
                      presence of a pathogenic mutation was $81.8\%.$ Among
                      cognitively asymptomatic ADAD family members, the occurrence
                      of seizures increases the a priori risk of $50\%$
                      mutation-positive status to about $80\%.$ This finding
                      suggests that ADAD mutations increase the risk of seizures.},
      keywords     = {Adult / Alzheimer Disease: complications / Alzheimer
                      Disease: genetics / Female / Genes, Dominant: genetics /
                      Genetic Association Studies / Heterozygote / Humans / Male /
                      Mutation: genetics / Observational Studies as Topic /
                      Predictive Value of Tests / Risk / Seizures: etiology /
                      Seizures: genetics},
      cin          = {AG Höglinger 1 / AG Jucker / AG Levin / U Clinical
                      Researchers - München},
      ddc          = {610},
      cid          = {I:(DE-2719)1110002 / I:(DE-2719)1210001 /
                      I:(DE-2719)1111016 / I:(DE-2719)7000003},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 342 -
                      Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30616208},
      pmc          = {pmc:PMC6572755},
      doi          = {10.1016/j.neurobiolaging.2018.11.022},
      url          = {https://pub.dzne.de/record/140511},
}