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000140513 0247_ $$2doi$$a10.1016/j.neurobiolaging.2018.12.010
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000140513 037__ $$aDZNE-2020-06835
000140513 041__ $$aEnglish
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000140513 1001_ $$0P:(DE-2719)2811087$$aMerhav, Maayan$$b0$$eFirst author$$udzne
000140513 245__ $$aSpatial updating deficits in human aging are associated with traces of former memory representations.
000140513 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2019
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000140513 520__ $$aThe ability to update spatial memories is important for everyday situations, such as remembering where we left our keys or parked our car. Although rodent studies have suggested that old age might impair spatial updating, direct evidence for such a deficit in humans is missing. Here, we tested whether spatial updating deficits occur in human aging, whether the learning mode influences spatial updating, and what mnemonic mechanism underlies the presumed deficits. To address these questions, younger and older participants had to indicate the latest location of relocated items, following either incidental or intentional learning. Using eye tracking, we further quantified memory traces of the original and updated locations. We found that older participants were selectively impaired in recalling locations of relocated items. Furthermore, they depicted relatively stronger representations of the original locations, which were correlated with their spatial updating deficits. The findings demonstrate that stronger representations of former spatial contexts can impair spatial updating in aging, a mechanism that can help explain the commonly observed age-related decline in spatial memory.
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000140513 650_2 $$2MeSH$$aAdult
000140513 650_2 $$2MeSH$$aAged
000140513 650_2 $$2MeSH$$aAging: psychology
000140513 650_2 $$2MeSH$$aFemale
000140513 650_2 $$2MeSH$$aHumans
000140513 650_2 $$2MeSH$$aLearning: physiology
000140513 650_2 $$2MeSH$$aMale
000140513 650_2 $$2MeSH$$aMemory Disorders: psychology
000140513 650_2 $$2MeSH$$aMental Recall
000140513 650_2 $$2MeSH$$aProactive Inhibition
000140513 650_2 $$2MeSH$$aSpace Perception: physiology
000140513 650_2 $$2MeSH$$aSpatial Memory: physiology
000140513 650_2 $$2MeSH$$aSpatial Navigation: physiology
000140513 650_2 $$2MeSH$$aYoung Adult
000140513 7001_ $$0P:(DE-2719)2813753$$aRiemer, Martin$$b1$$udzne
000140513 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b2$$eLast author$$udzne
000140513 77318 $$2Crossref$$3journal-article$$a10.1016/j.neurobiolaging.2018.12.010$$b : Elsevier BV, 2019-04-01$$p53-61$$tNeurobiology of Aging$$v76$$x0197-4580$$y2019
000140513 773__ $$0PERI:(DE-600)1498414-3$$a10.1016/j.neurobiolaging.2018.12.010$$gVol. 76, p. 53 - 61$$p53-61$$q76<53 - 61$$tNeurobiology of aging$$v76$$x0197-4580$$y2019
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