Home > Publications Database > Spatial updating deficits in human aging are associated with traces of former memory representations. > print

001     140513
005     20240321220825.0
024 7 _ |a 10.1016/j.neurobiolaging.2018.12.010
|2 doi
024 7 _ |a pmid:30703626
|2 pmid
024 7 _ |a 0197-4580
|2 ISSN
024 7 _ |a 1558-1497
|2 ISSN
024 7 _ |a altmetric:53570575
|2 altmetric
037 _ _ |a DZNE-2020-06835
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Merhav, Maayan
|0 P:(DE-2719)2811087
|b 0
|e First author
|u dzne
245 _ _ |a Spatial updating deficits in human aging are associated with traces of former memory representations.
260 _ _ |a Amsterdam [u.a.]
|c 2019
|b Elsevier Science
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2019-04-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1707493098_2405
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a The ability to update spatial memories is important for everyday situations, such as remembering where we left our keys or parked our car. Although rodent studies have suggested that old age might impair spatial updating, direct evidence for such a deficit in humans is missing. Here, we tested whether spatial updating deficits occur in human aging, whether the learning mode influences spatial updating, and what mnemonic mechanism underlies the presumed deficits. To address these questions, younger and older participants had to indicate the latest location of relocated items, following either incidental or intentional learning. Using eye tracking, we further quantified memory traces of the original and updated locations. We found that older participants were selectively impaired in recalling locations of relocated items. Furthermore, they depicted relatively stronger representations of the original locations, which were correlated with their spatial updating deficits. The findings demonstrate that stronger representations of former spatial contexts can impair spatial updating in aging, a mechanism that can help explain the commonly observed age-related decline in spatial memory.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
|0 G:(DE-HGF)POF3-344
|c POF3-344
|f POF III
|x 0
542 _ _ |i 2019-04-01
|2 Crossref
|u https://www.elsevier.com/tdm/userlicense/1.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aging: psychology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Learning: physiology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Memory Disorders: psychology
|2 MeSH
650 _ 2 |a Mental Recall
|2 MeSH
650 _ 2 |a Proactive Inhibition
|2 MeSH
650 _ 2 |a Space Perception: physiology
|2 MeSH
650 _ 2 |a Spatial Memory: physiology
|2 MeSH
650 _ 2 |a Spatial Navigation: physiology
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
700 1 _ |a Riemer, Martin
|0 P:(DE-2719)2813753
|b 1
|u dzne
700 1 _ |a Wolbers, Thomas
|0 P:(DE-2719)2810583
|b 2
|e Last author
|u dzne
773 1 8 |a 10.1016/j.neurobiolaging.2018.12.010
|b : Elsevier BV, 2019-04-01
|p 53-61
|3 journal-article
|2 Crossref
|t Neurobiology of Aging
|v 76
|y 2019
|x 0197-4580
773 _ _ |a 10.1016/j.neurobiolaging.2018.12.010
|g Vol. 76, p. 53 - 61
|0 PERI:(DE-600)1498414-3
|q 76<53 - 61
|p 53-61
|t Neurobiology of aging
|v 76
|y 2019
|x 0197-4580
856 4 _ |u https://pub.dzne.de/record/140513/files/DZNE-2020-06835_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/140513/files/DZNE-2020-06835_Restricted.pdf?subformat=pdfa
|x pdfa
909 C O |p VDB
|o oai:pub.dzne.de:140513
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)2811087
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 1
|6 P:(DE-2719)2813753
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 2
|6 P:(DE-2719)2810583
913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-344
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2019
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2022-11-10
|w ger
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b NEUROBIOL AGING : 2021
|d 2022-11-10
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2022-11-10
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2022-11-10
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2022-11-10
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2022-11-10
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2022-11-10
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2022-11-10
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2022-11-10
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2022-11-10
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b NEUROBIOL AGING : 2021
|d 2022-11-10
920 1 _ |0 I:(DE-2719)1310002
|k AG Wolbers
|l Aging, Cognition and Technology
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1310002
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21