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000140568 0247_ $$2doi$$a10.1016/j.neuroimage.2019.01.080
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000140568 0247_ $$2pmc$$apmc:PMC6669888
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000140568 0247_ $$2ISSN$$a1095-9572
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000140568 037__ $$aDZNE-2020-06890
000140568 041__ $$aEnglish
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000140568 1001_ $$aPremi, Enrico$$b0
000140568 245__ $$aThe inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.
000140568 260__ $$aOrlando, Fla.$$bAcademic Press$$c2019
000140568 264_1 $$2Crossref$$3print$$bElsevier BV$$c2019-04-01
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000140568 520__ $$aFrontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a 'chronnectome' approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 472 at-risk FTD subjects from the Genetic Frontotemporal dementia research Initiative (GENFI) cohort. We considered 249 subjects with FTD-related pathogenetic mutations and 223 mutation non-carriers (HC). Dynamic connectivity was evaluated using independent component analysis and sliding-time window correlation to rs-fMRI data, and meta-state measures of global brain flexibility were extracted. Results show that presymptomatic FTD exhibits diminished dynamic fluidity, visiting less meta-states, shifting less often across them, and travelling through a narrowed meta-state distance, as compared to HC. Dynamic connectivity changes characterize preclinical FTD, arguing for the desynchronization of the inner fluctuations of the brain. These changes antedate clinical symptoms, and might represent an early signature of FTD to be used as a biomarker in clinical trials.
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000140568 542__ $$2Crossref$$i2019-04-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
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000140568 650_2 $$2MeSH$$aAdult
000140568 650_2 $$2MeSH$$aConnectome: methods
000140568 650_2 $$2MeSH$$aFemale
000140568 650_2 $$2MeSH$$aFrontotemporal Dementia: diagnostic imaging
000140568 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000140568 650_2 $$2MeSH$$aFrontotemporal Dementia: physiopathology
000140568 650_2 $$2MeSH$$aHeterozygote
000140568 650_2 $$2MeSH$$aHumans
000140568 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000140568 650_2 $$2MeSH$$aMale
000140568 650_2 $$2MeSH$$aMiddle Aged
000140568 650_2 $$2MeSH$$aNerve Net: diagnostic imaging
000140568 650_2 $$2MeSH$$aNerve Net: physiopathology
000140568 650_2 $$2MeSH$$aProdromal Symptoms
000140568 650_2 $$2MeSH$$aTime Factors
000140568 7001_ $$aCalhoun, Vince D$$b1
000140568 7001_ $$aDiano, Matteo$$b2
000140568 7001_ $$aGazzina, Stefano$$b3
000140568 7001_ $$aCosseddu, Maura$$b4
000140568 7001_ $$aAlberici, Antonella$$b5
000140568 7001_ $$aArchetti, Silvana$$b6
000140568 7001_ $$aPaternicò, Donata$$b7
000140568 7001_ $$aGasparotti, Roberto$$b8
000140568 7001_ $$avan Swieten, John$$b9
000140568 7001_ $$aGalimberti, Daniela$$b10
000140568 7001_ $$aSanchez-Valle, Raquel$$b11
000140568 7001_ $$aLaforce, Robert$$b12
000140568 7001_ $$aMoreno, Fermin$$b13
000140568 7001_ $$0P:(DE-HGF)0$$aSynofzik, Matthis$$b14
000140568 7001_ $$aGraff, Caroline$$b15
000140568 7001_ $$aMasellis, Mario$$b16
000140568 7001_ $$aTartaglia, Maria Carmela$$b17
000140568 7001_ $$aRowe, James$$b18
000140568 7001_ $$aVandenberghe, Rik$$b19
000140568 7001_ $$aFinger, Elizabeth$$b20
000140568 7001_ $$aTagliavini, Fabrizio$$b21
000140568 7001_ $$ade Mendonça, Alexandre$$b22
000140568 7001_ $$aSantana, Isabel$$b23
000140568 7001_ $$aButler, Chris$$b24
000140568 7001_ $$aDucharme, Simon$$b25
000140568 7001_ $$aGerhard, Alex$$b26
000140568 7001_ $$0P:(DE-2719)2810712$$aDanek, Adrian$$b27$$udzne
000140568 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b28$$udzne
000140568 7001_ $$aOtto, Markus$$b29
000140568 7001_ $$aFrisoni, Giovanni$$b30
000140568 7001_ $$aCappa, Stefano$$b31
000140568 7001_ $$aSorbi, Sandro$$b32
000140568 7001_ $$aPadovani, Alessandro$$b33
000140568 7001_ $$aRohrer, Jonathan D$$b34
000140568 7001_ $$0P:(DE-HGF)0$$aBorroni, Barbara$$b35$$eCorresponding author
000140568 7001_ $$aGenetic FTD Initiative, GENFI$$b36
000140568 7001_ $$aAlmeida, Maria Rosario$$b37
000140568 7001_ $$aAnderl-Straub, Sarah$$b38
000140568 7001_ $$aAndersson, Christin$$b39
000140568 7001_ $$aAntonell, Anna$$b40
000140568 7001_ $$aArighi, Andrea$$b41
000140568 7001_ $$aBalasa, Mircea$$b42
000140568 7001_ $$aBarandiaran, Myriam$$b43
000140568 7001_ $$aBargalló, Nuria$$b44
000140568 7001_ $$aBartha, Robart$$b45
000140568 7001_ $$aBender, Benjamin$$b46
000140568 7001_ $$aBenussi, Luisa$$b47
000140568 7001_ $$aBinetti, Giuliano$$b48
000140568 7001_ $$aBlack, Sandra$$b49
000140568 7001_ $$aBocchetta, Martina$$b50
000140568 7001_ $$aBorrego-Ecija, Sergi$$b51
000140568 7001_ $$aBras, Jose$$b52
000140568 7001_ $$aBruffaerts, Rose$$b53
000140568 7001_ $$aCaroppo, Paola$$b54
000140568 7001_ $$aCash, David$$b55
000140568 7001_ $$aCastelo-Branco, Miguel$$b56
000140568 7001_ $$aConvery, Rhian$$b57
000140568 7001_ $$aCope, Thomas$$b58
000140568 7001_ $$ade Arriba, María$$b59
000140568 7001_ $$aDi Fede, Giuseppe$$b60
000140568 7001_ $$aDíaz, Zigor$$b61
000140568 7001_ $$aDick, Katrina M$$b62
000140568 7001_ $$aDuro, Diana$$b63
000140568 7001_ $$aFenoglio, Chiara$$b64
000140568 7001_ $$aFerreira, Carlos$$b65
000140568 7001_ $$aFerreira, Catarina B$$b66
000140568 7001_ $$aFlanagan, Toby$$b67
000140568 7001_ $$aFox, Nick$$b68
000140568 7001_ $$aFreedman, Morris$$b69
000140568 7001_ $$aFumagalli, Giorgio$$b70
000140568 7001_ $$aGabilondo, Alazne$$b71
000140568 7001_ $$aGauthier, Serge$$b72
000140568 7001_ $$aGhidoni, Roberta$$b73
000140568 7001_ $$aGiaccone, Giorgio$$b74
000140568 7001_ $$aGorostidi, Ana$$b75
000140568 7001_ $$aGreaves, Caroline$$b76
000140568 7001_ $$aGuerreiro, Rita$$b77
000140568 7001_ $$aHeller, Carolin$$b78
000140568 7001_ $$aHoegen, Tobias$$b79
000140568 7001_ $$aIndakoetxea, Begoña$$b80
000140568 7001_ $$aJelic, Vesna$$b81
000140568 7001_ $$aJiskoot, Lize$$b82
000140568 7001_ $$0P:(DE-HGF)0$$aKarnath, Hans-Otto$$b83
000140568 7001_ $$aKeren, Ron$$b84
000140568 7001_ $$aLeitão, Maria João$$b85
000140568 7001_ $$aLladó, Albert$$b86
000140568 7001_ $$aLombardi, Gemma$$b87
000140568 7001_ $$aLoosli, Sandra$$b88
000140568 7001_ $$aMaruta, Carolina$$b89
000140568 7001_ $$aMead, Simon$$b90
000140568 7001_ $$aMeeter, Lieke$$b91
000140568 7001_ $$aMiltenberger, Gabriel$$b92
000140568 7001_ $$avan Minkelen, Rick$$b93
000140568 7001_ $$aMitchell, Sara$$b94
000140568 7001_ $$aNacmias, Benedetta$$b95
000140568 7001_ $$aNeason, Mollie$$b96
000140568 7001_ $$aNicholas, Jennifer$$b97
000140568 7001_ $$aÖijerstedt, Linn$$b98
000140568 7001_ $$aOlives, Jaume$$b99
000140568 7001_ $$aPanman, Jessica$$b100
000140568 7001_ $$aPapma, Janne$$b101
000140568 7001_ $$aPatzig, Maximilian$$b102
000140568 7001_ $$aPievani, Michela$$b103
000140568 7001_ $$aPrioni, Sara$$b104
000140568 7001_ $$aPrix, Catharina$$b105
000140568 7001_ $$aRademakers, Rosa$$b106
000140568 7001_ $$aRedaelli, Veronica$$b107
000140568 7001_ $$aRittman, Tim$$b108
000140568 7001_ $$aRogaeva, Ekaterina$$b109
000140568 7001_ $$aRosa-Neto, Pedro$$b110
000140568 7001_ $$aRossi, Giacomina$$b111
000140568 7001_ $$aRossor, Martin$$b112
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000140568 7001_ $$aScarpini, Elio$$b114
000140568 7001_ $$aSemler, Elisa$$b115
000140568 7001_ $$aShafei, Rachelle$$b116
000140568 7001_ $$aShoesmith, Christen$$b117
000140568 7001_ $$aTábuas-Pereira, Miguel$$b118
000140568 7001_ $$aTainta, Mikel$$b119
000140568 7001_ $$aTang-Wai, David$$b120
000140568 7001_ $$aThomas, David L$$b121
000140568 7001_ $$aThonberg, Hakan$$b122
000140568 7001_ $$aTimberlake, Carolyn$$b123
000140568 7001_ $$aTiraboschi, Pietro$$b124
000140568 7001_ $$aVandamme, Philip$$b125
000140568 7001_ $$aVandenbulcke, Mathieu$$b126
000140568 7001_ $$aVeldsman, Michele$$b127
000140568 7001_ $$aVerdelho, Ana$$b128
000140568 7001_ $$aVillanua, Jorge$$b129
000140568 7001_ $$aWarren, Jason$$b130
000140568 7001_ $$0P:(DE-HGF)0$$aWilke, Carlo$$b131
000140568 7001_ $$aZetterberg, Henrik$$b132
000140568 7001_ $$aZulaica, Miren$$b133
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