TY  - JOUR
AU  - Premi, Enrico
AU  - Calhoun, Vince D
AU  - Diano, Matteo
AU  - Gazzina, Stefano
AU  - Cosseddu, Maura
AU  - Alberici, Antonella
AU  - Archetti, Silvana
AU  - Paternicò, Donata
AU  - Gasparotti, Roberto
AU  - van Swieten, John
AU  - Galimberti, Daniela
AU  - Sanchez-Valle, Raquel
AU  - Laforce, Robert
AU  - Moreno, Fermin
AU  - Synofzik, Matthis
AU  - Graff, Caroline
AU  - Masellis, Mario
AU  - Tartaglia, Maria Carmela
AU  - Rowe, James
AU  - Vandenberghe, Rik
AU  - Finger, Elizabeth
AU  - Tagliavini, Fabrizio
AU  - de Mendonça, Alexandre
AU  - Santana, Isabel
AU  - Butler, Chris
AU  - Ducharme, Simon
AU  - Gerhard, Alex
AU  - Danek, Adrian
AU  - Levin, Johannes
AU  - Otto, Markus
AU  - Frisoni, Giovanni
AU  - Cappa, Stefano
AU  - Sorbi, Sandro
AU  - Padovani, Alessandro
AU  - Rohrer, Jonathan D
AU  - Borroni, Barbara
AU  - Genetic FTD Initiative, GENFI
AU  - Almeida, Maria Rosario
AU  - Anderl-Straub, Sarah
AU  - Andersson, Christin
AU  - Antonell, Anna
AU  - Arighi, Andrea
AU  - Balasa, Mircea
AU  - Barandiaran, Myriam
AU  - Bargalló, Nuria
AU  - Bartha, Robart
AU  - Bender, Benjamin
AU  - Benussi, Luisa
AU  - Binetti, Giuliano
AU  - Black, Sandra
AU  - Bocchetta, Martina
AU  - Borrego-Ecija, Sergi
AU  - Bras, Jose
AU  - Bruffaerts, Rose
AU  - Caroppo, Paola
AU  - Cash, David
AU  - Castelo-Branco, Miguel
AU  - Convery, Rhian
AU  - Cope, Thomas
AU  - de Arriba, María
AU  - Di Fede, Giuseppe
AU  - Díaz, Zigor
AU  - Dick, Katrina M
AU  - Duro, Diana
AU  - Fenoglio, Chiara
AU  - Ferreira, Carlos
AU  - Ferreira, Catarina B
AU  - Flanagan, Toby
AU  - Fox, Nick
AU  - Freedman, Morris
AU  - Fumagalli, Giorgio
AU  - Gabilondo, Alazne
AU  - Gauthier, Serge
AU  - Ghidoni, Roberta
AU  - Giaccone, Giorgio
AU  - Gorostidi, Ana
AU  - Greaves, Caroline
AU  - Guerreiro, Rita
AU  - Heller, Carolin
AU  - Hoegen, Tobias
AU  - Indakoetxea, Begoña
AU  - Jelic, Vesna
AU  - Jiskoot, Lize
AU  - Karnath, Hans-Otto
AU  - Keren, Ron
AU  - Leitão, Maria João
AU  - Lladó, Albert
AU  - Lombardi, Gemma
AU  - Loosli, Sandra
AU  - Maruta, Carolina
AU  - Mead, Simon
AU  - Meeter, Lieke
AU  - Miltenberger, Gabriel
AU  - van Minkelen, Rick
AU  - Mitchell, Sara
AU  - Nacmias, Benedetta
AU  - Neason, Mollie
AU  - Nicholas, Jennifer
AU  - Öijerstedt, Linn
AU  - Olives, Jaume
AU  - Panman, Jessica
AU  - Papma, Janne
AU  - Patzig, Maximilian
AU  - Pievani, Michela
AU  - Prioni, Sara
AU  - Prix, Catharina
AU  - Rademakers, Rosa
AU  - Redaelli, Veronica
AU  - Rittman, Tim
AU  - Rogaeva, Ekaterina
AU  - Rosa-Neto, Pedro
AU  - Rossi, Giacomina
AU  - Rossor, Martin
AU  - Santiago, Beatriz
AU  - Scarpini, Elio
AU  - Semler, Elisa
AU  - Shafei, Rachelle
AU  - Shoesmith, Christen
AU  - Tábuas-Pereira, Miguel
AU  - Tainta, Mikel
AU  - Tang-Wai, David
AU  - Thomas, David L
AU  - Thonberg, Hakan
AU  - Timberlake, Carolyn
AU  - Tiraboschi, Pietro
AU  - Vandamme, Philip
AU  - Vandenbulcke, Mathieu
AU  - Veldsman, Michele
AU  - Verdelho, Ana
AU  - Villanua, Jorge
AU  - Warren, Jason
AU  - Wilke, Carlo
AU  - Zetterberg, Henrik
AU  - Zulaica, Miren
TI  - The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.
JO  - NeuroImage
VL  - 189
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - DZNE-2020-06890
SP  - 645-654
PY  - 2019
AB  - Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a 'chronnectome' approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 472 at-risk FTD subjects from the Genetic Frontotemporal dementia research Initiative (GENFI) cohort. We considered 249 subjects with FTD-related pathogenetic mutations and 223 mutation non-carriers (HC). Dynamic connectivity was evaluated using independent component analysis and sliding-time window correlation to rs-fMRI data, and meta-state measures of global brain flexibility were extracted. Results show that presymptomatic FTD exhibits diminished dynamic fluidity, visiting less meta-states, shifting less often across them, and travelling through a narrowed meta-state distance, as compared to HC. Dynamic connectivity changes characterize preclinical FTD, arguing for the desynchronization of the inner fluctuations of the brain. These changes antedate clinical symptoms, and might represent an early signature of FTD to be used as a biomarker in clinical trials.
KW  - Adult
KW  - Connectome: methods
KW  - Female
KW  - Frontotemporal Dementia: diagnostic imaging
KW  - Frontotemporal Dementia: genetics
KW  - Frontotemporal Dementia: physiopathology
KW  - Heterozygote
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Nerve Net: diagnostic imaging
KW  - Nerve Net: physiopathology
KW  - Prodromal Symptoms
KW  - Time Factors
LB  - PUB:(DE-HGF)16
C6  - pmid:30716457
C2  - pmc:PMC6669888
DO  - DOI:10.1016/j.neuroimage.2019.01.080
UR  - https://pub.dzne.de/record/140568
ER  -