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@ARTICLE{Premi:140568,
      author       = {Premi, Enrico and Calhoun, Vince D and Diano, Matteo and
                      Gazzina, Stefano and Cosseddu, Maura and Alberici, Antonella
                      and Archetti, Silvana and Paternicò, Donata and Gasparotti,
                      Roberto and van Swieten, John and Galimberti, Daniela and
                      Sanchez-Valle, Raquel and Laforce, Robert and Moreno, Fermin
                      and Synofzik, Matthis and Graff, Caroline and Masellis,
                      Mario and Tartaglia, Maria Carmela and Rowe, James and
                      Vandenberghe, Rik and Finger, Elizabeth and Tagliavini,
                      Fabrizio and de Mendonça, Alexandre and Santana, Isabel and
                      Butler, Chris and Ducharme, Simon and Gerhard, Alex and
                      Danek, Adrian and Levin, Johannes and Otto, Markus and
                      Frisoni, Giovanni and Cappa, Stefano and Sorbi, Sandro and
                      Padovani, Alessandro and Rohrer, Jonathan D and Borroni,
                      Barbara and Genetic FTD Initiative, GENFI and Almeida, Maria
                      Rosario and Anderl-Straub, Sarah and Andersson, Christin and
                      Antonell, Anna and Arighi, Andrea and Balasa, Mircea and
                      Barandiaran, Myriam and Bargalló, Nuria and Bartha, Robart
                      and Bender, Benjamin and Benussi, Luisa and Binetti,
                      Giuliano and Black, Sandra and Bocchetta, Martina and
                      Borrego-Ecija, Sergi and Bras, Jose and Bruffaerts, Rose and
                      Caroppo, Paola and Cash, David and Castelo-Branco, Miguel
                      and Convery, Rhian and Cope, Thomas and de Arriba, María
                      and Di Fede, Giuseppe and Díaz, Zigor and Dick, Katrina M
                      and Duro, Diana and Fenoglio, Chiara and Ferreira, Carlos
                      and Ferreira, Catarina B and Flanagan, Toby and Fox, Nick
                      and Freedman, Morris and Fumagalli, Giorgio and Gabilondo,
                      Alazne and Gauthier, Serge and Ghidoni, Roberta and
                      Giaccone, Giorgio and Gorostidi, Ana and Greaves, Caroline
                      and Guerreiro, Rita and Heller, Carolin and Hoegen, Tobias
                      and Indakoetxea, Begoña and Jelic, Vesna and Jiskoot, Lize
                      and Karnath, Hans-Otto and Keren, Ron and Leitão, Maria
                      João and Lladó, Albert and Lombardi, Gemma and Loosli,
                      Sandra and Maruta, Carolina and Mead, Simon and Meeter,
                      Lieke and Miltenberger, Gabriel and van Minkelen, Rick and
                      Mitchell, Sara and Nacmias, Benedetta and Neason, Mollie and
                      Nicholas, Jennifer and Öijerstedt, Linn and Olives, Jaume
                      and Panman, Jessica and Papma, Janne and Patzig, Maximilian
                      and Pievani, Michela and Prioni, Sara and Prix, Catharina
                      and Rademakers, Rosa and Redaelli, Veronica and Rittman, Tim
                      and Rogaeva, Ekaterina and Rosa-Neto, Pedro and Rossi,
                      Giacomina and Rossor, Martin and Santiago, Beatriz and
                      Scarpini, Elio and Semler, Elisa and Shafei, Rachelle and
                      Shoesmith, Christen and Tábuas-Pereira, Miguel and Tainta,
                      Mikel and Tang-Wai, David and Thomas, David L and Thonberg,
                      Hakan and Timberlake, Carolyn and Tiraboschi, Pietro and
                      Vandamme, Philip and Vandenbulcke, Mathieu and Veldsman,
                      Michele and Verdelho, Ana and Villanua, Jorge and Warren,
                      Jason and Wilke, Carlo and Zetterberg, Henrik and Zulaica,
                      Miren},
      title        = {{T}he inner fluctuations of the brain in presymptomatic
                      {F}rontotemporal {D}ementia: {T}he chronnectome
                      fingerprint.},
      journal      = {NeuroImage},
      volume       = {189},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2020-06890},
      pages        = {645-654},
      year         = {2019},
      abstract     = {Frontotemporal Dementia (FTD) is preceded by a long period
                      of subtle brain changes, occurring in the absence of overt
                      cognitive symptoms, that need to be still fully
                      characterized. Dynamic network analysis based on
                      resting-state magnetic resonance imaging (rs-fMRI) is a
                      potentially powerful tool for the study of preclinical FTD.
                      In the present study, we employed a 'chronnectome' approach
                      (recurring, time-varying patterns of connectivity) to
                      evaluate measures of dynamic connectivity in 472 at-risk
                      FTD subjects from the Genetic Frontotemporal dementia
                      research Initiative (GENFI) cohort. We considered 249
                      subjects with FTD-related pathogenetic mutations and 223
                      mutation non-carriers (HC). Dynamic connectivity was
                      evaluated using independent component analysis and
                      sliding-time window correlation to rs-fMRI data, and
                      meta-state measures of global brain flexibility were
                      extracted. Results show that presymptomatic FTD exhibits
                      diminished dynamic fluidity, visiting less meta-states,
                      shifting less often across them, and travelling through a
                      narrowed meta-state distance, as compared to HC. Dynamic
                      connectivity changes characterize preclinical FTD, arguing
                      for the desynchronization of the inner fluctuations of the
                      brain. These changes antedate clinical symptoms, and might
                      represent an early signature of FTD to be used as a
                      biomarker in clinical trials.},
      keywords     = {Adult / Connectome: methods / Female / Frontotemporal
                      Dementia: diagnostic imaging / Frontotemporal Dementia:
                      genetics / Frontotemporal Dementia: physiopathology /
                      Heterozygote / Humans / Magnetic Resonance Imaging / Male /
                      Middle Aged / Nerve Net: diagnostic imaging / Nerve Net:
                      physiopathology / Prodromal Symptoms / Time Factors},
      cin          = {U Clinical Researchers - München / AG Levin},
      ddc          = {610},
      cid          = {I:(DE-2719)7000003 / I:(DE-2719)1111016},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30716457},
      pmc          = {pmc:PMC6669888},
      doi          = {10.1016/j.neuroimage.2019.01.080},
      url          = {https://pub.dzne.de/record/140568},
}