001     140604
005     20250325125221.0
024 7 _ |a 10.15252/embr.201846449
|2 doi
024 7 _ |a pmid:30733280
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024 7 _ |a pmc:PMC6399600
|2 pmc
024 7 _ |a 1469-221X
|2 ISSN
024 7 _ |a 1469-3178
|2 ISSN
024 7 _ |a altmetric:55164813
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037 _ _ |a DZNE-2020-06926
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Niemeyer, Johannes
|0 P:(DE-HGF)0
|b 0
245 _ _ |a The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.
260 _ _ |a Hoboken, NJ [u.a.]
|c 2019
|b Wiley
264 _ 1 |3 online
|2 Crossref
|b EMBO
|c 2019-02-07
264 _ 1 |3 print
|2 Crossref
|b EMBO
|c 2019-03-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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|m journal
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Signal peptide peptidase (SPP) and the four homologous SPP-like (SPPL) proteases constitute a family of intramembrane aspartyl proteases with selectivity for type II-oriented transmembrane segments. Here, we analyse the physiological function of the orphan protease SPPL2c, previously considered to represent a non-expressed pseudogene. We demonstrate proteolytic activity of SPPL2c towards selected tail-anchored proteins. Despite shared ER localisation, SPPL2c and SPP exhibit distinct, though partially overlapping substrate spectra and inhibitory profiles, and are organised in different high molecular weight complexes. Interestingly, SPPL2c is specifically expressed in murine and human testis where it is primarily localised in spermatids. In mice, SPPL2c deficiency leads to a partial loss of elongated spermatids and reduced motility of mature spermatozoa, but preserved fertility. However, matings of male and female SPPL2c-/- mice exhibit reduced litter sizes. Using proteomics we identify the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2)-regulating protein phospholamban (PLN) as a physiological SPPL2c substrate. Accumulation of PLN correlates with a decrease in intracellular Ca2+ levels in elongated spermatids that likely contribute to the compromised male germ cell differentiation and function of SPPL2c-/- mice.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
|0 G:(DE-HGF)POF3-342
|c POF3-342
|f POF III
|x 0
542 _ _ |i 2019-02-07
|2 Crossref
|u http://onlinelibrary.wiley.com/termsAndConditions#vor
542 _ _ |i 2019-02-07
|2 Crossref
|u http://doi.wiley.com/10.1002/tdm_license_1.1
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Amino Acid Sequence
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Aspartic Acid Endopeptidases: chemistry
|2 MeSH
650 _ 2 |a Aspartic Acid Endopeptidases: metabolism
|2 MeSH
650 _ 2 |a Calcium: metabolism
|2 MeSH
650 _ 2 |a Calcium-Binding Proteins: metabolism
|2 MeSH
650 _ 2 |a Cell Membrane: enzymology
|2 MeSH
650 _ 2 |a Endoplasmic Reticulum: metabolism
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Germ Cells: metabolism
|2 MeSH
650 _ 2 |a HEK293 Cells
|2 MeSH
650 _ 2 |a HeLa Cells
|2 MeSH
650 _ 2 |a Homeostasis
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Membrane Proteins: chemistry
|2 MeSH
650 _ 2 |a Membrane Proteins: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Organ Specificity
|2 MeSH
650 _ 2 |a Spermatids: metabolism
|2 MeSH
650 _ 2 |a Substrate Specificity
|2 MeSH
650 _ 2 |a Testis: enzymology
|2 MeSH
700 1 _ |a Mentrup, Torben
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Heidasch, Ronny
|0 P:(DE-HGF)0
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700 1 _ |a Müller, Stephan A
|0 P:(DE-2719)2810938
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|u dzne
700 1 _ |a Biswas, Uddipta
|0 P:(DE-HGF)0
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700 1 _ |a Meyer, Rieke
|0 P:(DE-HGF)0
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700 1 _ |a Papadopoulou, Alkmini A
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700 1 _ |a Dederer, Verena
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700 1 _ |a Haug-Kröper, Martina
|b 8
700 1 _ |a Adamski, Vivian
|b 9
700 1 _ |a Lüllmann-Rauch, Renate
|b 10
700 1 _ |a Bergmann, Martin
|b 11
700 1 _ |a Mayerhofer, Artur
|b 12
700 1 _ |a Saftig, Paul
|b 13
700 1 _ |a Wennemuth, Gunther
|b 14
700 1 _ |a Jessberger, Rolf
|b 15
700 1 _ |a Fluhrer, Regina
|0 P:(DE-2719)2000007
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700 1 _ |a Lichtenthaler, Stefan F
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700 1 _ |a Lemberg, Marius K
|b 18
700 1 _ |a Schröder, Bernd
|0 P:(DE-HGF)0
|b 19
|e Corresponding author
773 1 8 |a 10.15252/embr.201846449
|b : EMBO, 2019-02-07
|n 3
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|t EMBO reports
|v 20
|y 2019
|x 1469-221X
773 _ _ |a 10.15252/embr.201846449
|g Vol. 20, no. 3
|0 PERI:(DE-600)2025376-X
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|q 20:3
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|t EMBO reports
|v 20
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856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399600
856 4 _ |u https://pub.dzne.de/record/140604/files/DZNE-2020-06926_Restricted.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
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914 1 _ |y 2019
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LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21