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| 001 | 140605 | ||
| 005 | 20250325125502.0 | ||
| 024 | 7 | _ | |a 10.15252/embr.201846451 |2 doi |
| 024 | 7 | _ | |a pmid:30733281 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6399617 |2 pmc |
| 024 | 7 | _ | |a 1469-221X |2 ISSN |
| 024 | 7 | _ | |a 1469-3178 |2 ISSN |
| 024 | 7 | _ | |a altmetric:55164815 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06927 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Papadopoulou, Alkmini A |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleaves SNARE proteins. |
| 260 | _ | _ | |a Hoboken, NJ [u.a.] |c 2019 |b Wiley |
| 264 | _ | 1 | |3 online |2 Crossref |b EMBO |c 2019-02-07 |
| 264 | _ | 1 | |3 print |2 Crossref |b EMBO |c 2019-03-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1742903570_2887 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a Title corrected according to Corrigendum: EMBO rep (2019) 20: e48133 https://doi.org/10.15252/embr.201948133 |
| 520 | _ | _ | |a Members of the GxGD-type intramembrane aspartyl proteases have emerged as key players not only in fundamental cellular processes such as B-cell development or protein glycosylation, but also in development of pathologies, such as Alzheimer's disease or hepatitis virus infections. However, one member of this protease family, signal peptide peptidase-like 2c (SPPL2c), remains orphan and its capability of proteolysis as well as its physiological function is still enigmatic. Here, we demonstrate that SPPL2c is catalytically active and identify a variety of SPPL2c candidate substrates using proteomics. The majority of the SPPL2c candidate substrates cluster to the biological process of vesicular trafficking. Analysis of selected SNARE proteins reveals proteolytic processing by SPPL2c that impairs vesicular transport and causes retention of cargo proteins in the endoplasmic reticulum. As a consequence, the integrity of subcellular compartments, in particular the Golgi, is disturbed. Together with a strikingly high physiological SPPL2c expression in testis, our data suggest involvement of SPPL2c in acrosome formation during spermatogenesis. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2019-02-07 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions#vor |
| 542 | _ | _ | |i 2019-02-07 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Müller, Stephan A |0 P:(DE-2719)2810938 |b 1 |u dzne |
| 700 | 1 | _ | |a Mentrup, Torben |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Shmueli, Merav D |0 P:(DE-2719)2812458 |b 3 |u dzne |
| 700 | 1 | _ | |a Niemeyer, Johannes |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Haug-Kröper, Martina |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a von Blume, Julia |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Mayerhofer, Artur |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Feederle, Regina |0 P:(DE-2719)2812867 |b 8 |u dzne |
| 700 | 1 | _ | |a Schröder, Bernd |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Lichtenthaler, Stefan F |0 P:(DE-2719)2181459 |b 10 |u dzne |
| 700 | 1 | _ | |a Fluhrer, Regina |0 P:(DE-2719)2000007 |b 11 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.15252/embr.201846451 |b : EMBO, 2019-02-07 |n 3 |3 journal-article |2 Crossref |t EMBO reports |v 20 |y 2019 |x 1469-221X |
| 773 | _ | _ | |a 10.15252/embr.201846451 |g Vol. 20, no. 3 |0 PERI:(DE-600)2025376-X |n 3 |q 20:3 |p e46451 |t EMBO reports |v 20 |y 2019 |x 1469-221X |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399617 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/140605/files/DZNE-2020-06927_Restricted.pdf |
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| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2019 |
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| 920 | 1 | _ | |0 I:(DE-2719)1110007 |k AG Haass |l Molecular Neurodegeneration |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1110006 |k AG Lichtenthaler |l Neuroproteomics |x 1 |
| 920 | 1 | _ | |0 I:(DE-2719)1140004 |k AG Feederle |l Antibody Production |x 2 |
| 920 | 1 | _ | |0 I:(DE-2719)1110000-2 |k AG Fluhrer |l Signal Peptide Peptidases as Models for γ-Secretase |x 3 |
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