TY  - JOUR
AU  - Bouter, Caroline
AU  - Vogelgsang, Jonathan
AU  - Wiltfang, Jens
TI  - Comparison between amyloid-PET and CSF amyloid-β biomarkers in a clinical cohort with memory deficits.
JO  - Clinica chimica acta
VL  - 492
SN  - 0009-8981
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-06931
SP  - 62-68
PY  - 2019
AB  - With increasing prevalence of Alzheimer's disease (AD) and advances in research of therapeutic approaches, an early and accurate in-vivo diagnosis is crucial. Different biomarkers that are able to identify AD are currently in focus. However, whether and to which extend results of cerebrospinal fluid (CSF) and imaging biomarkers are comparable, is unclear. This study aims to correlate CSF and amyloid imaging biomarkers comparing them to cognitive measurements in order to determine whether these methods provide identical or complementary information. The study comprises 33 consecutive patients with suspected cognitive decline that underwent lumbar puncture for CSF biomarker analysis and Amyloid-PET/CT within the diagnostic evaluation of memory impairment. Amyloid PET/CTs were evaluated visually and quantitatively. CSF and imaging data were retrospectively evaluated and results were compared to cognition tests, age, gender, and ApoE status. Global cortex SUVr levels correlated highly with CSF Aβ42/40 and moderately with Aβ42 but not with Aβ40. Global cortex SUVr and Aβ42/40 correlated with mini mental status examination. This study indicates that Amyloid-PET and CSF biomarkers might not reflect identical clinical information and a combination of both seems to be the most accurate way to characterize clinically unclear cognitive decline.
KW  - Aged
KW  - Aging: metabolism
KW  - Amyloid beta-Peptides: cerebrospinal fluid
KW  - Apolipoproteins E: cerebrospinal fluid
KW  - Biomarkers: cerebrospinal fluid
KW  - Case-Control Studies
KW  - Cognition
KW  - Cohort Studies
KW  - Female
KW  - Humans
KW  - Male
KW  - Memory Disorders: cerebrospinal fluid
KW  - Memory Disorders: diagnostic imaging
KW  - Memory Disorders: physiopathology
KW  - Middle Aged
KW  - Positron Emission Tomography Computed Tomography
KW  - Retrospective Studies
KW  - Sex Characteristics
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Apolipoproteins E (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:30735665
DO  - DOI:10.1016/j.cca.2019.02.005
UR  - https://pub.dzne.de/record/140609
ER  -