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@ARTICLE{Bouter:140609,
      author       = {Bouter, Caroline and Vogelgsang, Jonathan and Wiltfang,
                      Jens},
      title        = {{C}omparison between amyloid-{PET} and {CSF} amyloid-β
                      biomarkers in a clinical cohort with memory deficits.},
      journal      = {Clinica chimica acta},
      volume       = {492},
      issn         = {0009-8981},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-06931},
      pages        = {62-68},
      year         = {2019},
      abstract     = {With increasing prevalence of Alzheimer's disease (AD) and
                      advances in research of therapeutic approaches, an early and
                      accurate in-vivo diagnosis is crucial. Different biomarkers
                      that are able to identify AD are currently in focus.
                      However, whether and to which extend results of
                      cerebrospinal fluid (CSF) and imaging biomarkers are
                      comparable, is unclear. This study aims to correlate CSF and
                      amyloid imaging biomarkers comparing them to cognitive
                      measurements in order to determine whether these methods
                      provide identical or complementary information. The study
                      comprises 33 consecutive patients with suspected cognitive
                      decline that underwent lumbar puncture for CSF biomarker
                      analysis and Amyloid-PET/CT within the diagnostic evaluation
                      of memory impairment. Amyloid PET/CTs were evaluated
                      visually and quantitatively. CSF and imaging data were
                      retrospectively evaluated and results were compared to
                      cognition tests, age, gender, and ApoE status. Global cortex
                      SUVr levels correlated highly with CSF Aβ42/40 and
                      moderately with Aβ42 but not with Aβ40. Global cortex SUVr
                      and Aβ42/40 correlated with mini mental status examination.
                      This study indicates that Amyloid-PET and CSF biomarkers
                      might not reflect identical clinical information and a
                      combination of both seems to be the most accurate way to
                      characterize clinically unclear cognitive decline.},
      keywords     = {Aged / Aging: metabolism / Amyloid beta-Peptides:
                      cerebrospinal fluid / Apolipoproteins E: cerebrospinal fluid
                      / Biomarkers: cerebrospinal fluid / Case-Control Studies /
                      Cognition / Cohort Studies / Female / Humans / Male / Memory
                      Disorders: cerebrospinal fluid / Memory Disorders:
                      diagnostic imaging / Memory Disorders: physiopathology /
                      Middle Aged / Positron Emission Tomography Computed
                      Tomography / Retrospective Studies / Sex Characteristics /
                      Amyloid beta-Peptides (NLM Chemicals) / Apolipoproteins E
                      (NLM Chemicals) / Biomarkers (NLM Chemicals)},
      cin          = {AG Wiltfang},
      ddc          = {610},
      cid          = {I:(DE-2719)1410006},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30735665},
      doi          = {10.1016/j.cca.2019.02.005},
      url          = {https://pub.dzne.de/record/140609},
}