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000140615 0247_ $$2doi$$a10.1016/j.neuroscience.2018.03.048
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000140615 037__ $$aDZNE-2020-06937
000140615 041__ $$aEnglish
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000140615 1001_ $$0P:(DE-HGF)0$$aDe Santis, Silvia$$b0$$eCorresponding author
000140615 245__ $$aCharacterizing Microstructural Tissue Properties in Multiple Sclerosis with Diffusion MRI at 7 T and 3 T: The Impact of the Experimental Design.
000140615 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2019
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000140615 520__ $$aThe recent introduction of advanced magnetic resonance (MR) imaging techniques to characterize focal and global degeneration in multiple sclerosis (MS), like the Composite Hindered and Restricted Model of Diffusion, or CHARMED, diffusional kurtosis imaging (DKI) and Neurite Orientation Dispersion and Density Imaging (NODDI) made available new tools to image axonal pathology non-invasively in vivo. These methods already showed greater sensitivity and specificity compared to conventional diffusion tensor-based metrics (e.g., fractional anisotropy), overcoming some of its limitations. While previous studies uncovered global and focal axonal degeneration in MS patients compared to healthy controls, here our aim is to investigate and compare different diffusion MRI acquisition protocols in their ability to highlight microstructural differences between MS and control tissue over several much used models. For comparison, we contrasted the ability of fractional anisotropy measurements to uncover differences between lesion, normal-appearing white matter (WM), gray matter and healthy tissue under the same imaging protocols. We show that: (1) focal and diffuse differences in several microstructural parameters are observed under clinical settings; (2) advanced models (CHARMED, DKI and NODDI) have increased specificity and sensitivity to neurodegeneration when compared to fractional anisotropy measurements; and (3) both high (3 T) and ultra-high fields (7 T) are viable options for imaging tissue change in MS lesions and normal appearing WM, while higher b-values are less beneficial under the tested short-time (10 min acquisition) conditions.
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000140615 650_2 $$2MeSH$$aAdult
000140615 650_2 $$2MeSH$$aCohort Studies
000140615 650_2 $$2MeSH$$aDiffusion Magnetic Resonance Imaging: instrumentation
000140615 650_2 $$2MeSH$$aDiffusion Magnetic Resonance Imaging: methods
000140615 650_2 $$2MeSH$$aHumans
000140615 650_2 $$2MeSH$$aImage Interpretation, Computer-Assisted
000140615 650_2 $$2MeSH$$aMultiple Sclerosis: diagnostic imaging
000140615 650_2 $$2MeSH$$aMultiple Sclerosis: therapy
000140615 650_2 $$2MeSH$$aNerve Degeneration: diagnostic imaging
000140615 650_2 $$2MeSH$$aResearch Design
000140615 650_2 $$2MeSH$$aSensitivity and Specificity
000140615 650_2 $$2MeSH$$aTime Factors
000140615 7001_ $$aBastiani, Matteo$$b1
000140615 7001_ $$aDroby, Amgad$$b2
000140615 7001_ $$aKolber, Pierre$$b3
000140615 7001_ $$aZipp, Frauke$$b4
000140615 7001_ $$0P:(DE-2719)2810559$$aPracht, Eberhard$$b5$$udzne
000140615 7001_ $$0P:(DE-2719)2810538$$aStöcker, Tony$$b6$$udzne
000140615 7001_ $$aGroppa, Sergiu$$b7
000140615 7001_ $$aRoebroeck, Alard$$b8
000140615 77318 $$2Crossref$$3journal-article$$a10.1016/j.neuroscience.2018.03.048$$b : Elsevier BV, 2019-04-01$$p17-26$$tNeuroscience$$v403$$x0306-4522$$y2019
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