TY  - JOUR
AU  - De Santis, Silvia
AU  - Bastiani, Matteo
AU  - Droby, Amgad
AU  - Kolber, Pierre
AU  - Zipp, Frauke
AU  - Pracht, Eberhard
AU  - Stöcker, Tony
AU  - Groppa, Sergiu
AU  - Roebroeck, Alard
TI  - Characterizing Microstructural Tissue Properties in Multiple Sclerosis with Diffusion MRI at 7 T and 3 T: The Impact of the Experimental Design.
JO  - Neuroscience
VL  - 403
SN  - 0306-4522
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-06937
SP  - 17-26
PY  - 2019
AB  - The recent introduction of advanced magnetic resonance (MR) imaging techniques to characterize focal and global degeneration in multiple sclerosis (MS), like the Composite Hindered and Restricted Model of Diffusion, or CHARMED, diffusional kurtosis imaging (DKI) and Neurite Orientation Dispersion and Density Imaging (NODDI) made available new tools to image axonal pathology non-invasively in vivo. These methods already showed greater sensitivity and specificity compared to conventional diffusion tensor-based metrics (e.g., fractional anisotropy), overcoming some of its limitations. While previous studies uncovered global and focal axonal degeneration in MS patients compared to healthy controls, here our aim is to investigate and compare different diffusion MRI acquisition protocols in their ability to highlight microstructural differences between MS and control tissue over several much used models. For comparison, we contrasted the ability of fractional anisotropy measurements to uncover differences between lesion, normal-appearing white matter (WM), gray matter and healthy tissue under the same imaging protocols. We show that: (1) focal and diffuse differences in several microstructural parameters are observed under clinical settings; (2) advanced models (CHARMED, DKI and NODDI) have increased specificity and sensitivity to neurodegeneration when compared to fractional anisotropy measurements; and (3) both high (3 T) and ultra-high fields (7 T) are viable options for imaging tissue change in MS lesions and normal appearing WM, while higher b-values are less beneficial under the tested short-time (10 min acquisition) conditions.
KW  - Adult
KW  - Cohort Studies
KW  - Diffusion Magnetic Resonance Imaging: instrumentation
KW  - Diffusion Magnetic Resonance Imaging: methods
KW  - Humans
KW  - Image Interpretation, Computer-Assisted
KW  - Multiple Sclerosis: diagnostic imaging
KW  - Multiple Sclerosis: therapy
KW  - Nerve Degeneration: diagnostic imaging
KW  - Research Design
KW  - Sensitivity and Specificity
KW  - Time Factors
LB  - PUB:(DE-HGF)16
C6  - pmid:29631021
DO  - DOI:10.1016/j.neuroscience.2018.03.048
UR  - https://pub.dzne.de/record/140615
ER  -