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@ARTICLE{DeSantis:140615,
      author       = {De Santis, Silvia and Bastiani, Matteo and Droby, Amgad and
                      Kolber, Pierre and Zipp, Frauke and Pracht, Eberhard and
                      Stöcker, Tony and Groppa, Sergiu and Roebroeck, Alard},
      title        = {{C}haracterizing {M}icrostructural {T}issue {P}roperties in
                      {M}ultiple {S}clerosis with {D}iffusion {MRI} at 7 {T} and
                      3 {T}: {T}he {I}mpact of the {E}xperimental {D}esign.},
      journal      = {Neuroscience},
      volume       = {403},
      issn         = {0306-4522},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-06937},
      pages        = {17-26},
      year         = {2019},
      abstract     = {The recent introduction of advanced magnetic resonance (MR)
                      imaging techniques to characterize focal and global
                      degeneration in multiple sclerosis (MS), like the Composite
                      Hindered and Restricted Model of Diffusion, or CHARMED,
                      diffusional kurtosis imaging (DKI) and Neurite Orientation
                      Dispersion and Density Imaging (NODDI) made available new
                      tools to image axonal pathology non-invasively in vivo.
                      These methods already showed greater sensitivity and
                      specificity compared to conventional diffusion tensor-based
                      metrics (e.g., fractional anisotropy), overcoming some of
                      its limitations. While previous studies uncovered global and
                      focal axonal degeneration in MS patients compared to healthy
                      controls, here our aim is to investigate and compare
                      different diffusion MRI acquisition protocols in their
                      ability to highlight microstructural differences between MS
                      and control tissue over several much used models. For
                      comparison, we contrasted the ability of fractional
                      anisotropy measurements to uncover differences between
                      lesion, normal-appearing white matter (WM), gray matter and
                      healthy tissue under the same imaging protocols. We show
                      that: (1) focal and diffuse differences in several
                      microstructural parameters are observed under clinical
                      settings; (2) advanced models (CHARMED, DKI and NODDI) have
                      increased specificity and sensitivity to neurodegeneration
                      when compared to fractional anisotropy measurements; and (3)
                      both high (3 T) and ultra-high fields (7 T) are viable
                      options for imaging tissue change in MS lesions and normal
                      appearing WM, while higher b-values are less beneficial
                      under the tested short-time (10 min acquisition)
                      conditions.},
      keywords     = {Adult / Cohort Studies / Diffusion Magnetic Resonance
                      Imaging: instrumentation / Diffusion Magnetic Resonance
                      Imaging: methods / Humans / Image Interpretation,
                      Computer-Assisted / Multiple Sclerosis: diagnostic imaging /
                      Multiple Sclerosis: therapy / Nerve Degeneration: diagnostic
                      imaging / Research Design / Sensitivity and Specificity /
                      Time Factors},
      cin          = {AG Stöcker},
      ddc          = {610},
      cid          = {I:(DE-2719)1013026},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29631021},
      doi          = {10.1016/j.neuroscience.2018.03.048},
      url          = {https://pub.dzne.de/record/140615},
}