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| Home > Publications Database > TRIAD3/RNF216 E3 ligase specifically synthesises K63-linked ubiquitin chains and is inactivated by mutations associated with Gordon Holmes syndrome. > print |
| Home > Publications Database > TRIAD3/RNF216 E3 ligase specifically synthesises K63-linked ubiquitin chains and is inactivated by mutations associated with Gordon Holmes syndrome. > print |
| 001 | 140619 | ||
| 005 | 20240430120009.0 | ||
| 024 | 7 | _ | |a 10.1038/s41420-019-0158-6 |2 doi |
| 024 | 7 | _ | |a pmid:30886743 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6411869 |2 pmc |
| 024 | 7 | _ | |a altmetric:57930719 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06941 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Schwintzer, Lukas |0 P:(DE-2719)2810987 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a TRIAD3/RNF216 E3 ligase specifically synthesises K63-linked ubiquitin chains and is inactivated by mutations associated with Gordon Holmes syndrome. |
| 260 | _ | _ | |a London |c 2019 |b Nature Publishing Group |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2019-03-11 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2019-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1714468365_8221 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a TRIAD3/RNF216 is a ubiquitin ligase of the RING-in-between-RING family. Recent publications identified TRIAD3 mutations in patients with neurological diseases, including Gordon Holmes syndrome and Huntington-like disorder. To understand the functional relevance of these disease-associated mutations, we have tested the ubiquitin ligase activity of mutated TRIAD3 in vitro. Several of these point mutations completely abrogated TRIAD3's catalytic activity. Using mass spectrometry, we identified new TRIAD3-interacting proteins/substrates from mouse brain lysate, which provide a new link between TRIAD3 and processes involving clathrin-mediated endocytosis. Strikingly, we found that TRIAD3 synthesises specifically lysine-63 (K63)-linked poly-ubiquitin chains in vitro, a chain type that usually plays a role in mediating signalling events rather than triggering proteasomal degradation. Therefore, this finding is of great importance to further understand TRIAD3's cellular role and loss-of-function in disease. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 542 | _ | _ | |i 2019-03-11 |2 Crossref |u https://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Aguado Roca, Eva |0 P:(DE-2719)2810320 |b 1 |u dzne |
| 700 | 1 | _ | |a Broemer, Meike |0 P:(DE-2719)2810307 |b 2 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1038/s41420-019-0158-6 |b : Springer Science and Business Media LLC, 2019-03-11 |n 1 |p 75 |3 journal-article |2 Crossref |t Cell Death Discovery |v 5 |y 2019 |x 2058-7716 |
| 773 | _ | _ | |a 10.1038/s41420-019-0158-6 |g Vol. 5, no. 1, p. 75 |0 PERI:(DE-600)2842546-7 |n 1 |q 5:1<75 |p 75 |t Cell death discovery |v 5 |y 2019 |x 2058-7716 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/140619/files/DZNE-2020-06941.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/140619/files/DZNE-2020-06941.pdf?subformat=pdfa |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411869 |
| 909 | C | O | |o oai:pub.dzne.de:140619 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2810987 |
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