000140621 001__ 140621
000140621 005__ 20240430120009.0
000140621 0247_ $$2doi$$a10.1038/s41420-017-0003-8
000140621 0247_ $$2pmid$$apmid:29531801
000140621 0247_ $$2pmc$$apmc:PMC5841321
000140621 0247_ $$2altmetric$$aaltmetric:32357431
000140621 037__ $$aDZNE-2020-06943
000140621 041__ $$aEnglish
000140621 082__ $$a610
000140621 1001_ $$0P:(DE-2719)2810945$$aMatthes, Frank$$b0$$eFirst author
000140621 245__ $$aInhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis.
000140621 260__ $$aLondon$$bNature Publishing Group$$c2018
000140621 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2018-01-29
000140621 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2018-12-01
000140621 3367_ $$2DRIVER$$aarticle
000140621 3367_ $$2DataCite$$aOutput Types/Journal article
000140621 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1714467224_8222
000140621 3367_ $$2BibTeX$$aARTICLE
000140621 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000140621 3367_ $$00$$2EndNote$$aJournal Article
000140621 520__ $$aAlzheimer's disease (AD) is characterized by two neuropathological hallmarks: senile plaques, which are composed of amyloid-β (Aβ) peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated tau protein. Aβ peptides are derived from sequential proteolytic cleavage of the amyloid precursor protein (APP). In this study, we identified a so far unknown mode of regulation of APP protein synthesis involving the MID1 protein complex: MID1 binds to and regulates the translation of APP mRNA. The underlying mode of action of MID1 involves the mTOR pathway. Thus, inhibition of the MID1 complex reduces the APP protein level in cultures of primary neurons. Based on this, we used one compound that we discovered previously to interfere with the MID1 complex, metformin, for in vivo experiments. Indeed, long-term treatment with metformin decreased APP protein expression levels and consequently Aβ in an AD mouse model. Importantly, we have initiated the metformin treatment late in life, at a time-point where mice were in an already progressed state of the disease, and could observe an improved behavioral phenotype. These findings together with our previous observation, showing that inhibition of the MID1 complex by metformin also decreases tau phosphorylation, make the MID1 complex a particularly interesting drug target for treating AD.
000140621 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000140621 542__ $$2Crossref$$i2018-01-29$$uhttp://creativecommons.org/licenses/by/4.0
000140621 588__ $$aDataset connected to CrossRef, PubMed,
000140621 7001_ $$0P:(DE-2719)2380493$$aHettich, Moritz M$$b1
000140621 7001_ $$0P:(DE-2719)2810643$$aSchilling, Judith$$b2
000140621 7001_ $$0P:(DE-2719)9000076$$aFlores-Dominguez, Diana$$b3
000140621 7001_ $$0P:(DE-2719)2811722$$aBlank, Nelli$$b4
000140621 7001_ $$aWiglenda, Thomas$$b5
000140621 7001_ $$aBuntru, Alexander$$b6
000140621 7001_ $$0P:(DE-2719)2630412$$aWolf, Hanna$$b7
000140621 7001_ $$0P:(DE-2719)2662310$$aWeber, Stephanie$$b8
000140621 7001_ $$0P:(DE-2719)2481765$$aVorberg, Ina$$b9
000140621 7001_ $$aDagane, Alina$$b10
000140621 7001_ $$aDittmar, Gunnar$$b11
000140621 7001_ $$aWanker, Erich$$b12
000140621 7001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b13
000140621 7001_ $$0P:(DE-2719)2421562$$aKrauß, Sybille$$b14$$eLast author$$udzne
000140621 77318 $$2Crossref$$3journal-article$$a10.1038/s41420-017-0003-8$$b : Springer Science and Business Media LLC, 2018-01-29$$n1$$p4$$tCell Death Discovery$$v4$$x2058-7716$$y2018
000140621 773__ $$0PERI:(DE-600)2842546-7$$a10.1038/s41420-017-0003-8$$gVol. 4, no. 1, p. 4$$n1$$p4$$q4:1<4$$tCell death discovery$$v4$$x2058-7716$$y2018
000140621 8564_ $$uhttps://pub.dzne.de/record/140621/files/DZNE-2020-06943.pdf$$yOpenAccess
000140621 8564_ $$uhttps://pub.dzne.de/record/140621/files/DZNE-2020-06943.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000140621 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841321
000140621 909CO $$ooai:pub.dzne.de:140621$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810945$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2380493$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810643$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000076$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811722$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2630412$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2662310$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2481765$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2289209$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000140621 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2421562$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000140621 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000140621 9141_ $$y2018
000140621 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-03-31
000140621 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2021-02-14T16:19:13Z
000140621 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCELL DEATH DISCOV : 2021$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-02-14T16:19:13Z
000140621 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-02-14T16:19:13Z
000140621 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000140621 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-02-14T16:19:13Z
000140621 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCELL DEATH DISCOV : 2021$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-03-31
000140621 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-03-31
000140621 9201_ $$0I:(DE-2719)1011006$$kAG Krauß$$lRegulatory RNA-protein interaction in neurodegenerative diseases$$x0
000140621 9201_ $$0I:(DE-2719)1013005$$kAG Ehninger$$lTranslational Biogerontology$$x1
000140621 9201_ $$0I:(DE-2719)1013004$$kAG Vorberg$$lPrion Cell Biology$$x2
000140621 980__ $$ajournal
000140621 980__ $$aVDB
000140621 980__ $$aUNRESTRICTED
000140621 980__ $$aI:(DE-2719)1011006
000140621 980__ $$aI:(DE-2719)1013005
000140621 980__ $$aI:(DE-2719)1013004
000140621 9801_ $$aFullTexts
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/ca.980080612$$o10.1002/ca.980080612
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.7326/0003-4819-113-6-429$$o10.7326/0003-4819-113-6-429
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1192/bjp.157.1.72$$o10.1192/bjp.157.1.72
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.94.1.298$$o10.1073/pnas.94.1.298
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00702-004-0221-0$$o10.1007/s00702-004-0221-0
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1159/000067425$$o10.1159/000067425
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0912793107$$o10.1073/pnas.0912793107
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ng762$$o10.1038/ng762
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1100131108$$o10.1073/pnas.1100131108
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1101/gad.887201$$o10.1101/gad.887201
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M111.224451$$o10.1074/jbc.M111.224451
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncomms2514$$o10.1038/ncomms2514
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00439-007-0456-6$$o10.1007/s00439-007-0456-6
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/1471-2407-14-52$$o10.1186/1471-2407-14-52
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0102420$$o10.1371/journal.pone.0102420
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/1476-4598-13-146$$o10.1186/1476-4598-13-146
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1432-1033.1969.tb00629.x$$o10.1111/j.1432-1033.1969.tb00629.x
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2006.01.016$$o10.1016/j.cell.2006.01.016
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1042/BST20120080$$o10.1042/BST20120080
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M110.100420$$o10.1074/jbc.M110.100420
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1532-5415.2012.03916.x$$o10.1111/j.1532-5415.2012.03916.x
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2337/dc13-0229$$o10.2337/dc13-0229
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuropharm.2011.01.033$$o10.1016/j.neuropharm.2011.01.033
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0807991106$$o10.1073/pnas.0807991106
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.pbb.2012.03.002$$o10.1016/j.pbb.2012.03.002
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3233/JAD-141332$$o10.3233/JAD-141332
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.bbamcr.2015.01.017$$o10.1016/j.bbamcr.2015.01.017
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0005088$$o10.1371/journal.pone.0005088
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00216-015-8595-4$$o10.1007/s00216-015-8595-4
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nprot.2007.261$$o10.1038/nprot.2007.261
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nbt.1511$$o10.1038/nbt.1511
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0910723107$$o10.1073/pnas.0910723107
000140621 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nsmb.1437$$o10.1038/nsmb.1437