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000140630 1001_ $$0P:(DE-2719)9000937$$aLeiter, Odette$$b0$$eFirst author
000140630 245__ $$aExercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation.
000140630 260__ $$a[New York, NY]$$bElsevier$$c2019
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000140630 520__ $$aPhysical activity is a strong positive physiological modulator of adult neurogenesis in the hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still unknown, systemic processes must be involved. Here we show that platelets are activated after acute periods of running, and that activated platelets promote neurogenesis, an effect that is likely mediated by platelet factor 4. Ex vivo, the beneficial effects of activated platelets and platelet factor 4 on neural precursor cells were dentate gyrus specific and not observed in the subventricular zone. Moreover, the depletion of circulating platelets in mice abolished the running-induced increase in precursor cell proliferation in the dentate gyrus following exercise. These findings demonstrate that platelets and their released factors can modulate adult neural precursor cells under physiological conditions and provide an intriguing link between running-induced platelet activation and the modulation of neurogenesis after exercise.
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000140630 650_2 $$2MeSH$$aAnimals
000140630 650_2 $$2MeSH$$aBlood Platelets: metabolism
000140630 650_2 $$2MeSH$$aCell Proliferation
000140630 650_2 $$2MeSH$$aDentate Gyrus: metabolism
000140630 650_2 $$2MeSH$$aHippocampus: metabolism
000140630 650_2 $$2MeSH$$aMice
000140630 650_2 $$2MeSH$$aNeural Stem Cells: cytology
000140630 650_2 $$2MeSH$$aNeural Stem Cells: metabolism
000140630 650_2 $$2MeSH$$aNeurogenesis
000140630 650_2 $$2MeSH$$aNeurons: cytology
000140630 650_2 $$2MeSH$$aNeurons: metabolism
000140630 650_2 $$2MeSH$$aPlatelet Activation
000140630 650_2 $$2MeSH$$aProteome
000140630 7001_ $$aSeidemann, Suse$$b1
000140630 7001_ $$0P:(DE-2719)2812530$$aOverall, Rupert W$$b2
000140630 7001_ $$aRamasz, Beáta$$b3
000140630 7001_ $$0P:(DE-2719)2811674$$aRund, Nicole$$b4
000140630 7001_ $$aSchallenberg, Sonja$$b5
000140630 7001_ $$aGrinenko, Tatyana$$b6
000140630 7001_ $$aWielockx, Ben$$b7
000140630 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b8
000140630 7001_ $$0P:(DE-2719)9000335$$aWalker, Tara$$b9$$eLast author
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