TY  - JOUR
AU  - Leiter, Odette
AU  - Seidemann, Suse
AU  - Overall, Rupert W
AU  - Ramasz, Beáta
AU  - Rund, Nicole
AU  - Schallenberg, Sonja
AU  - Grinenko, Tatyana
AU  - Wielockx, Ben
AU  - Kempermann, Gerd
AU  - Walker, Tara
TI  - Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation.
JO  - Stem cell reports
VL  - 12
IS  - 4
SN  - 2213-6711
CY  - [New York, NY]
PB  - Elsevier
M1  - DZNE-2020-06952
SP  - 667-679
PY  - 2019
AB  - Physical activity is a strong positive physiological modulator of adult neurogenesis in the hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still unknown, systemic processes must be involved. Here we show that platelets are activated after acute periods of running, and that activated platelets promote neurogenesis, an effect that is likely mediated by platelet factor 4. Ex vivo, the beneficial effects of activated platelets and platelet factor 4 on neural precursor cells were dentate gyrus specific and not observed in the subventricular zone. Moreover, the depletion of circulating platelets in mice abolished the running-induced increase in precursor cell proliferation in the dentate gyrus following exercise. These findings demonstrate that platelets and their released factors can modulate adult neural precursor cells under physiological conditions and provide an intriguing link between running-induced platelet activation and the modulation of neurogenesis after exercise.
KW  - Animals
KW  - Blood Platelets: metabolism
KW  - Cell Proliferation
KW  - Dentate Gyrus: metabolism
KW  - Hippocampus: metabolism
KW  - Mice
KW  - Neural Stem Cells: cytology
KW  - Neural Stem Cells: metabolism
KW  - Neurogenesis
KW  - Neurons: cytology
KW  - Neurons: metabolism
KW  - Platelet Activation
KW  - Proteome
LB  - PUB:(DE-HGF)16
C6  - pmid:30905740
C2  - pmc:PMC6450435
DO  - DOI:10.1016/j.stemcr.2019.02.009
UR  - https://pub.dzne.de/record/140630
ER  -