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@ARTICLE{Leiter:140630,
      author       = {Leiter, Odette and Seidemann, Suse and Overall, Rupert W
                      and Ramasz, Beáta and Rund, Nicole and Schallenberg, Sonja
                      and Grinenko, Tatyana and Wielockx, Ben and Kempermann, Gerd
                      and Walker, Tara},
      title        = {{E}xercise-{I}nduced {A}ctivated {P}latelets {I}ncrease
                      {A}dult {H}ippocampal {P}recursor {P}roliferation and
                      {P}romote {N}euronal {D}ifferentiation.},
      journal      = {Stem cell reports},
      volume       = {12},
      number       = {4},
      issn         = {2213-6711},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-06952},
      pages        = {667-679},
      year         = {2019},
      abstract     = {Physical activity is a strong positive physiological
                      modulator of adult neurogenesis in the hippocampal dentate
                      gyrus. Although the underlying regulatory mechanisms are
                      still unknown, systemic processes must be involved. Here we
                      show that platelets are activated after acute periods of
                      running, and that activated platelets promote neurogenesis,
                      an effect that is likely mediated by platelet factor 4.
                      Ex vivo, the beneficial effects of activated platelets and
                      platelet factor 4 on neural precursor cells were dentate
                      gyrus specific and not observed in the subventricular zone.
                      Moreover, the depletion of circulating platelets in mice
                      abolished the running-induced increase in precursor cell
                      proliferation in the dentate gyrus following exercise. These
                      findings demonstrate that platelets and their released
                      factors can modulate adult neural precursor cells under
                      physiological conditions and provide an intriguing link
                      between running-induced platelet activation and the
                      modulation of neurogenesis after exercise.},
      keywords     = {Animals / Blood Platelets: metabolism / Cell Proliferation
                      / Dentate Gyrus: metabolism / Hippocampus: metabolism / Mice
                      / Neural Stem Cells: cytology / Neural Stem Cells:
                      metabolism / Neurogenesis / Neurons: cytology / Neurons:
                      metabolism / Platelet Activation / Proteome},
      cin          = {Dresden common / AG Kempermann},
      ddc          = {610},
      cid          = {I:(DE-2719)6000013 / I:(DE-2719)1710001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30905740},
      pmc          = {pmc:PMC6450435},
      doi          = {10.1016/j.stemcr.2019.02.009},
      url          = {https://pub.dzne.de/record/140630},
}