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| 001 | 140635 | ||
| 005 | 20240321220839.0 | ||
| 024 | 7 | _ | |a 10.1038/s41418-018-0164-x |2 doi |
| 024 | 7 | _ | |a pmid:30026495 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6462001 |2 pmc |
| 024 | 7 | _ | |a 1350-9047 |2 ISSN |
| 024 | 7 | _ | |a 1476-5403 |2 ISSN |
| 024 | 7 | _ | |a altmetric:45225269 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06957 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Aalto, Anna L |b 0 |
| 245 | _ | _ | |a M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila. |
| 260 | _ | _ | |a London |c 2019 |b Macmillan |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2018-07-19 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2019-05-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1588089481_27436 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Post-translational modifications such as ubiquitination play a key role in regulation of inflammatory nuclear factor-κB (NF-κB) signalling. The Drosophila IκB kinase γ (IKKγ) Kenny is a central regulator of the Drosophila Imd pathway responsible for activation of the NF-κB Relish. We found the Drosophila E3 ligase and HOIL-1L interacting protein (HOIP) orthologue linear ubiquitin E3 ligase (LUBEL) to catalyse formation of M1-linked linear ubiquitin (M1-Ub) chains in flies in a signal-dependent manner upon bacterial infection. Upon activation of the Imd pathway, LUBEL modifies Kenny with M1-Ub chains. Interestingly, the LUBEL-mediated M1-Ub chains seem to be targeted both directly to Kenny and to K63-linked ubiquitin chains conjugated to Kenny by DIAP2. This suggests that DIAP2 and LUBEL work together to promote Kenny-mediated activation of Relish. We found LUBEL-mediated M1-Ub chain formation to be required for flies to survive oral infection with Gram-negative bacteria, for activation of Relish-mediated expression of antimicrobial peptide genes and for pathogen clearance during oral infection. Interestingly, LUBEL is not required for mounting an immune response against systemic infection, as Relish-mediated antimicrobial peptide genes can be expressed in the absence of LUBEL during septic injury. Finally, transgenic induction of LUBEL-mediated M1-Ub drives expression of antimicrobial peptide genes and hyperplasia in the midgut in the absence of infection. This suggests that M1-Ub chains are important for Imd signalling and immune responses in the intestinal epithelia, and that enhanced M1-Ub chain formation is able to drive chronic intestinal inflammation in flies. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 542 | _ | _ | |i 2018-07-19 |2 Crossref |u https://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Bacterial Infections: genetics |2 MeSH |
| 650 | _ | 2 | |a Bacterial Infections: microbiology |2 MeSH |
| 650 | _ | 2 | |a Disease Models, Animal |2 MeSH |
| 650 | _ | 2 | |a Drosophila: genetics |2 MeSH |
| 650 | _ | 2 | |a Drosophila Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Gram-Negative Bacteria: pathogenicity |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Immunity, Innate: genetics |2 MeSH |
| 650 | _ | 2 | |a Inflammation: genetics |2 MeSH |
| 650 | _ | 2 | |a Inflammation: microbiology |2 MeSH |
| 650 | _ | 2 | |a Inhibitor of Apoptosis Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Mouth: microbiology |2 MeSH |
| 650 | _ | 2 | |a Mouth: pathology |2 MeSH |
| 650 | _ | 2 | |a NF-kappa B: genetics |2 MeSH |
| 650 | _ | 2 | |a Protein Processing, Post-Translational: genetics |2 MeSH |
| 650 | _ | 2 | |a RNA-Binding Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Signal Transduction: genetics |2 MeSH |
| 650 | _ | 2 | |a Transcription Factors: genetics |2 MeSH |
| 650 | _ | 2 | |a Ubiquitin: genetics |2 MeSH |
| 650 | _ | 2 | |a Ubiquitin-Protein Ligases: genetics |2 MeSH |
| 650 | _ | 2 | |a Ubiquitination: genetics |2 MeSH |
| 700 | 1 | _ | |a Mohan, Aravind K |b 1 |
| 700 | 1 | _ | |a Schwintzer, Lukas |0 P:(DE-2719)2810987 |b 2 |u dzne |
| 700 | 1 | _ | |a Kupka, Sebastian |b 3 |
| 700 | 1 | _ | |a Kietz, Christa |b 4 |
| 700 | 1 | _ | |a Walczak, Henning |b 5 |
| 700 | 1 | _ | |a Broemer, Meike |0 P:(DE-2719)2810307 |b 6 |u dzne |
| 700 | 1 | _ | |a Meinander, Annika |0 P:(DE-HGF)0 |b 7 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1038/s41418-018-0164-x |b : Springer Science and Business Media LLC, 2018-07-19 |n 5 |p 860-876 |3 journal-article |2 Crossref |t Cell Death & Differentiation |v 26 |y 2018 |x 1350-9047 |
| 773 | _ | _ | |a 10.1038/s41418-018-0164-x |g Vol. 26, no. 5, p. 860 - 876 |0 PERI:(DE-600)1496681-5 |n 5 |q 26:5<860 - 876 |p 860-876 |t Cell death and differentiation |v 26 |y 2018 |x 1350-9047 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462001 |
| 909 | C | O | |o oai:pub.dzne.de:140635 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 2 |6 P:(DE-2719)2810987 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 6 |6 P:(DE-2719)2810307 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-341 |2 G:(DE-HGF)POF3-300 |v Molecular Signaling |x 0 |
| 914 | 1 | _ | |y 2019 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-30 |
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| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-30 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b CELL DEATH DIFFER : 2021 |d 2022-11-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-30 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-30 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b CELL DEATH DIFFER : 2021 |d 2022-11-30 |
| 920 | 1 | _ | |0 I:(DE-2719)5000021 |k AG Brömer 1 |l Ubiquitin-mediated Processes in Neurodegenerative Diseases |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)5000021 |
| 980 | _ | _ | |a UNRESTRICTED |
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