TY  - JOUR
AU  - Graf, Heiko
AU  - Malejko, Kathrin
AU  - Metzger, Coraline Danielle
AU  - Walter, Martin
AU  - Grön, Georg
AU  - Abler, Birgit
TI  - Serotonergic, Dopaminergic, and Noradrenergic Modulation of Erotic Stimulus Processing in the Male Human Brain.
JO  - Journal of Clinical Medicine
VL  - 8
IS  - 3
SN  - 2077-0383
CY  - Basel
PB  - MDPI
M1  - DZNE-2020-06964
SP  - 363
PY  - 2019
AB  - Human sexual behavior is mediated by a complex interplay of cerebral and spinal centers, as well as hormonal, peripheral, and autonomic functions. Neuroimaging studies identified central neural signatures of human sexual responses comprising neural emotional, motivational, autonomic, and cognitive components. However, empirical evidence regarding the neuromodulation of these neural signatures of human sexual responses was scarce for decades. Pharmacological functional magnetic resonance imaging (fMRI) provides a valuable tool to examine the interaction between neuromodulator systems and functional network anatomy relevant for human sexual behavior. In addition, this approach enables the examination of potential neural mechanisms regarding treatment-related sexual dysfunction under psychopharmacological agents. In this article, we introduce common neurobiological concepts regarding cerebral sexual responses based on neuroimaging findings and we discuss challenges and findings regarding investigating the neuromodulation of neural sexual stimulus processing. In particular, we summarize findings from our research program investigating how neural correlates of sexual stimulus processing are modulated by serotonergic, dopaminergic, and noradrenergic antidepressant medication in healthy males.
LB  - PUB:(DE-HGF)16
C6  - pmid:30875818
C2  - pmc:PMC6463265
DO  - DOI:10.3390/jcm8030363
UR  - https://pub.dzne.de/record/140642
ER  -