guest ::
| Home > Publications Database > Cerebrospinal fluid biogenic amines depletion and brain atrophy in adult patients with phenylketonuria. > print |
| Home > Publications Database > Cerebrospinal fluid biogenic amines depletion and brain atrophy in adult patients with phenylketonuria. > print |
| 001 | 140655 | ||
| 005 | 20250415124311.0 | ||
| 024 | 7 | _ | |a 10.1002/jimd.12049 |2 doi |
| 024 | 7 | _ | |a pmid:30706953 |2 pmid |
| 024 | 7 | _ | |a 0141-8955 |2 ISSN |
| 024 | 7 | _ | |a 1573-2665 |2 ISSN |
| 024 | 7 | _ | |a altmetric:65970830 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06977 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Pilotto, Andrea |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Cerebrospinal fluid biogenic amines depletion and brain atrophy in adult patients with phenylketonuria. |
| 260 | _ | _ | |a Dordrecht [u.a.] |c 2019 |b Springer Science + Business Media B.V |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2019-02-01 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2019-05-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1744713736_8417 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Biogenic amines synthesis in phenylketonuria (PKU) patients with high phenylalanine (Phe) concentration is thought to be impaired due to inhibition of tyrosine and tryptophan hydroxylases and competition with amino acids at the blood-brain barrier. Dopamine and serotonin deficits might explain brain damage and progressive neuropsychiatric impairment in adult PKU patients. Ten early treated adult PKU patients (mean age 38.2 years) and 15 age-matched controls entered the study. Plasma and cerebrospinal fluid (CSF) Phe, 5-hydroxyindoleacetic acid (5-HIAA), 5-hydroxytryptophan (5-HTP), 3,4-dihydroxy-l-phenylalanine (l-DOPA) and homovanillic acid (HVA) were analyzed. Voxel-based morphometry statistical nonparametric mapping was used to test the age-corrected correlation between gray matter atrophy and CSF biogenic amines levels. 5-HIAA and 5-HTP were significantly reduced in PKU patients compared to controls. Significant negative correlations were found between CSF 5-HIAA, HVA, and 5-HTP and Phe levels. A decrease in 5-HIAA and 5-HTP concentrations correlated with precuneus and frontal atrophy, respectively. Lower HVA levels correlated with occipital atrophy. Biogenic amines deficits correlate with specific brain atrophy patterns in adult PKU patients, in line with serotonin and dopamine projections. These findings may support a more rigorous Phe control in adult PKU to prevent neurotransmitter depletion and accelerated brain damage due to aging. |
| 536 | _ | _ | |a 345 - Population Studies and Genetics (POF3-345) |0 G:(DE-HGF)POF3-345 |c POF3-345 |f POF III |x 0 |
| 542 | _ | _ | |i 2019-02-01 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 542 | _ | _ | |i 2019-02-01 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions#vor |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Atrophy |2 MeSH |
| 650 | _ | 2 | |a Biogenic Amines: blood |2 MeSH |
| 650 | _ | 2 | |a Biogenic Amines: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Case-Control Studies |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Gray Matter: pathology |2 MeSH |
| 650 | _ | 2 | |a Homovanillic Acid: blood |2 MeSH |
| 650 | _ | 2 | |a Homovanillic Acid: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Linear Models |2 MeSH |
| 650 | _ | 2 | |a Magnetic Resonance Imaging |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Phenylketonurias: blood |2 MeSH |
| 650 | _ | 2 | |a Phenylketonurias: cerebrospinal fluid |2 MeSH |
| 700 | 1 | _ | |a Blau, Nenad |b 1 |
| 700 | 1 | _ | |a Leks, Edytha |b 2 |
| 700 | 1 | _ | |a Schulte, Claudia |0 P:(DE-2719)9000366 |b 3 |u dzne |
| 700 | 1 | _ | |a Deuschle, Christian |0 P:(DE-2719)2812432 |b 4 |u dzne |
| 700 | 1 | _ | |a Zipser, Carl |b 5 |
| 700 | 1 | _ | |a Piel, David |b 6 |
| 700 | 1 | _ | |a Freisinger, Peter |b 7 |
| 700 | 1 | _ | |a Gramer, Gwendolyn |b 8 |
| 700 | 1 | _ | |a Kölker, Stefan |b 9 |
| 700 | 1 | _ | |a Haas, Dorothea |b 10 |
| 700 | 1 | _ | |a Burgard, Peter |b 11 |
| 700 | 1 | _ | |a Nawroth, Peter |b 12 |
| 700 | 1 | _ | |a Georg, Hoffmann |b 13 |
| 700 | 1 | _ | |a Scheffler, Klaus |b 14 |
| 700 | 1 | _ | |a Berg, Daniela |0 P:(DE-2719)2000059 |b 15 |u dzne |
| 700 | 1 | _ | |a Trefz, Friedrich |b 16 |
| 773 | 1 | 8 | |a 10.1002/jimd.12049 |b : Wiley, 2019-02-01 |n 3 |p 398-406 |3 journal-article |2 Crossref |t Journal of Inherited Metabolic Disease |v 42 |y 2019 |x 0141-8955 |
| 773 | _ | _ | |a 10.1002/jimd.12049 |g Vol. 42, no. 3, p. 398 - 406 |0 PERI:(DE-600)2006875-X |n 3 |q 42:3<398 - 406 |p 398-406 |t Journal of inherited metabolic disease |v 42 |y 2019 |x 0141-8955 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/140655/files/DZNE-2020-06977_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/140655/files/DZNE-2020-06977_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:140655 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 3 |6 P:(DE-2719)9000366 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 4 |6 P:(DE-2719)2812432 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 15 |6 P:(DE-2719)2000059 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-345 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Population Studies and Genetics |x 0 |
| 914 | 1 | _ | |y 2019 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2022-11-23 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-23 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b J INHERIT METAB DIS : 2021 |d 2022-11-23 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2022-11-23 |
| 920 | 1 | _ | |0 I:(DE-2719)5000055 |k AG Berg |l Parkinson's Disease Genetics |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1210000 |k AG Gasser |l Parkinson Genetics |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)5000055 |
| 980 | _ | _ | |a I:(DE-2719)1210000 |
| 980 | _ | _ | |a UNRESTRICTED |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0140-6736(10)60961-0 |2 Crossref |o 10.1016/S0140-6736(10)60961-0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.jpeds.2013.12.015 |2 Crossref |o 10.1016/j.jpeds.2013.12.015 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1023/A:1005694122277 |2 Crossref |o 10.1023/A:1005694122277 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ymgme.2016.02.004 |2 Crossref |o 10.1016/j.ymgme.2016.02.004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.spen.2016.11.007 |2 Crossref |o 10.1016/j.spen.2016.11.007 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00431-014-2458-4 |2 Crossref |o 10.1007/s00431-014-2458-4 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00415-005-0860-6 |2 Crossref |o 10.1007/s00415-005-0860-6 |
| 999 | C | 5 | |y 2015 |2 Crossref |o Velema 2015 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S2213-8587(16)30320-5 |2 Crossref |o 10.1016/S2213-8587(16)30320-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/gim.2013.157 |2 Crossref |o 10.1038/gim.2013.157 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/978-3-540-76698-8 |2 Crossref |o 10.1007/978-3-540-76698-8 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1006/nimg.2000.0582 |2 Crossref |o 10.1006/nimg.2000.0582 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/hbm.1058 |2 Crossref |o 10.1002/hbm.1058 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/mrm.21983 |2 Crossref |o 10.1002/mrm.21983 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1097/00001756-200212200-00036 |2 Crossref |o 10.1097/00001756-200212200-00036 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1017/S0033291717001398 |2 Crossref |o 10.1017/S0033291717001398 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0022-3476(81)80832-3 |2 Crossref |o 10.1016/S0022-3476(81)80832-3 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s10545-012-9473-2 |2 Crossref |o 10.1007/s10545-012-9473-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ymgme.2012.08.007 |2 Crossref |o 10.1016/j.ymgme.2012.08.007 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s10545-011-9318-4 |2 Crossref |o 10.1007/s10545-011-9318-4 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.celrep.2014.06.042 |2 Crossref |o 10.1016/j.celrep.2014.06.042 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neurobiolaging.2014.07.008 |2 Crossref |o 10.1016/j.neurobiolaging.2014.07.008 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1117104109 |2 Crossref |o 10.1073/pnas.1117104109 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S1474-4422(17)30159-X |2 Crossref |o 10.1016/S1474-4422(17)30159-X |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neurobiolaging.2017.01.013 |2 Crossref |o 10.1016/j.neurobiolaging.2017.01.013 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S1474-4422(11)70158-2 |2 Crossref |o 10.1016/S1474-4422(11)70158-2 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.0000000000003322 |2 Crossref |o 10.1212/WNL.0000000000003322 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/sj.jcbfm.9600571 |2 Crossref |o 10.1038/sj.jcbfm.9600571 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.ymgme.2012.10.021 |2 Crossref |o 10.1016/j.ymgme.2012.10.021 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/brain/119.2.523 |2 Crossref |o 10.1093/brain/119.2.523 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.0000000000005161 |2 Crossref |o 10.1212/WNL.0000000000005161 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0140-6736(15)00462-6 |2 Crossref |o 10.1016/S0140-6736(15)00462-6 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/mds.27035 |2 Crossref |o 10.1002/mds.27035 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.brainresbull.2013.10.003 |2 Crossref |o 10.1016/j.brainresbull.2013.10.003 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|