%0 Journal Article
%A Alexopoulos, Panagiotis
%A Thierjung, Nathalie
%A Economou, Polychronis
%A Werle, Lukas
%A Buhl, Felix
%A Kagerbauer, Simone
%A Papanastasiou, Anastasios D
%A Grimmer, Timo
%A Gourzis, Philippos
%A Berthele, Achim
%A Hemmer, Bernhard
%A Kübler, Hubert
%A Martin, Jan
%A Politis, Antonios
%A Perneczky, Robert
%T Plasma Levels of Soluble AβPPβ as a Biomarker for Alzheimer's Disease with Dementia.
%J Journal of Alzheimer's disease
%V 69
%N 1
%@ 1387-2877
%C Amsterdam
%I IOS Press
%M DZNE-2020-07008
%P 83-90
%D 2019
%X Cost- and time-effective markers of Alzheimer’s disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-β protein precursor β (sAβPPβ) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sAβPPβ levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N = 33) are significantly lower (p < 0.01) than those of cognitively healthy elderly individuals without AD (N = 39), while CSF sAβPPβ levels did not differ between the studied groups. This provides further evidence for the potential of sAβPPβ in plasma as an AD biomarker candidate.
%K Aged
%K Alzheimer Disease: blood
%K Alzheimer Disease: cerebrospinal fluid
%K Alzheimer Disease: diagnosis
%K Amyloid beta-Protein Precursor: blood
%K Amyloid beta-Protein Precursor: cerebrospinal fluid
%K Biomarkers: blood
%K Biomarkers: cerebrospinal fluid
%K Dementia: blood
%K Dementia: diagnosis
%K Female
%K Humans
%K Male
%K Middle Aged
%K tau Proteins: cerebrospinal fluid
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30909232
%R 10.3233/JAD-181088
%U https://pub.dzne.de/record/140686