TY  - JOUR
AU  - Alexopoulos, Panagiotis
AU  - Thierjung, Nathalie
AU  - Economou, Polychronis
AU  - Werle, Lukas
AU  - Buhl, Felix
AU  - Kagerbauer, Simone
AU  - Papanastasiou, Anastasios D
AU  - Grimmer, Timo
AU  - Gourzis, Philippos
AU  - Berthele, Achim
AU  - Hemmer, Bernhard
AU  - Kübler, Hubert
AU  - Martin, Jan
AU  - Politis, Antonios
AU  - Perneczky, Robert
TI  - Plasma Levels of Soluble AβPPβ as a Biomarker for Alzheimer's Disease with Dementia.
JO  - Journal of Alzheimer's disease
VL  - 69
IS  - 1
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2020-07008
SP  - 83-90
PY  - 2019
AB  - Cost- and time-effective markers of Alzheimer’s disease (AD), reliable and feasible at the population level are urgently needed. Soluble amyloid-β protein precursor β (sAβPPβ) in plasma has attracted scientific attention as a potential AD biomarker candidate. Here we report that plasma sAβPPβ levels in patients with AD dementia and typical for AD cerebrospinal fluid (CSF) biomarker profiles (N = 33) are significantly lower (p < 0.01) than those of cognitively healthy elderly individuals without AD (N = 39), while CSF sAβPPβ levels did not differ between the studied groups. This provides further evidence for the potential of sAβPPβ in plasma as an AD biomarker candidate.
KW  - Aged
KW  - Alzheimer Disease: blood
KW  - Alzheimer Disease: cerebrospinal fluid
KW  - Alzheimer Disease: diagnosis
KW  - Amyloid beta-Protein Precursor: blood
KW  - Amyloid beta-Protein Precursor: cerebrospinal fluid
KW  - Biomarkers: blood
KW  - Biomarkers: cerebrospinal fluid
KW  - Dementia: blood
KW  - Dementia: diagnosis
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - tau Proteins: cerebrospinal fluid
LB  - PUB:(DE-HGF)16
C6  - pmid:30909232
DO  - DOI:10.3233/JAD-181088
UR  - https://pub.dzne.de/record/140686
ER  -