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@ARTICLE{Alexopoulos:140686,
      author       = {Alexopoulos, Panagiotis and Thierjung, Nathalie and
                      Economou, Polychronis and Werle, Lukas and Buhl, Felix and
                      Kagerbauer, Simone and Papanastasiou, Anastasios D and
                      Grimmer, Timo and Gourzis, Philippos and Berthele, Achim and
                      Hemmer, Bernhard and Kübler, Hubert and Martin, Jan and
                      Politis, Antonios and Perneczky, Robert},
      title        = {{P}lasma {L}evels of {S}oluble {A}β{PP}β as a {B}iomarker
                      for {A}lzheimer's {D}isease with {D}ementia.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {69},
      number       = {1},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2020-07008},
      pages        = {83-90},
      year         = {2019},
      abstract     = {Cost- and time-effective markers of Alzheimer’s disease
                      (AD), reliable and feasible at the population level are
                      urgently needed. Soluble amyloid-β protein precursor β
                      (sAβPPβ) in plasma has attracted scientific attention as a
                      potential AD biomarker candidate. Here we report that plasma
                      sAβPPβ levels in patients with AD dementia and typical for
                      AD cerebrospinal fluid (CSF) biomarker profiles (N = 33)
                      are significantly lower (p < 0.01) than those of
                      cognitively healthy elderly individuals without AD
                      (N = 39), while CSF sAβPPβ levels did not differ
                      between the studied groups. This provides further evidence
                      for the potential of sAβPPβ in plasma as an AD biomarker
                      candidate.},
      keywords     = {Aged / Alzheimer Disease: blood / Alzheimer Disease:
                      cerebrospinal fluid / Alzheimer Disease: diagnosis / Amyloid
                      beta-Protein Precursor: blood / Amyloid beta-Protein
                      Precursor: cerebrospinal fluid / Biomarkers: blood /
                      Biomarkers: cerebrospinal fluid / Dementia: blood /
                      Dementia: diagnosis / Female / Humans / Male / Middle Aged /
                      tau Proteins: cerebrospinal fluid},
      cin          = {AG Levin},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30909232},
      doi          = {10.3233/JAD-181088},
      url          = {https://pub.dzne.de/record/140686},
}