guest ::
| Home > Publications Database > Critical role for Piccolo in synaptic vesicle retrieval. > print |
| 001 | 140720 | ||
| 005 | 20240430120011.0 | ||
| 024 | 7 | _ | |a 10.7554/eLife.46629 |2 doi |
| 024 | 7 | _ | |a pmid:31074746 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6541439 |2 pmc |
| 024 | 7 | _ | |a altmetric:60251519 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-07042 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 600 |
| 100 | 1 | _ | |a Ackermann, Frauke |0 P:(DE-2719)2810967 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Critical role for Piccolo in synaptic vesicle retrieval. |
| 260 | _ | _ | |a Cambridge |c 2019 |b eLife Sciences Publications |
| 264 | _ | 1 | |3 online |2 Crossref |b eLife Sciences Publications, Ltd |c 2019-05-10 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1714464544_8220 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy. Here, we address how Piccolo inactivation in rat neurons adversely affects synaptic function and thus may contribute to neuronal loss. Our analysis shows that Piccolo is critical for the recycling and maintenance of synaptic vesicles. We find that boutons lacking Piccolo have deficits in the Rab5/EEA1 dependent formation of early endosomes and thus the recycling of SVs. Mechanistically, impaired Rab5 function was caused by reduced synaptic recruitment of Pra1, known to interact selectively with the zinc finger domains of Piccolo. Importantly, over-expression of GTPase deficient Rab5 or the Znf1 domain of Piccolo restores the size and recycling of SV pools. These data provide a molecular link between the active zone and endosome sorting at synapses providing hints to how Piccolo contributes to developmental and psychiatric disorders. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 542 | _ | _ | |i 2019-05-10 |2 Crossref |u http://creativecommons.org/licenses/by/4.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Axons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cytoskeletal Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a DNA Transposable Elements: genetics |2 MeSH |
| 650 | _ | 2 | |a Endosomes: metabolism |2 MeSH |
| 650 | _ | 2 | |a GTP Phosphohydrolases: metabolism |2 MeSH |
| 650 | _ | 2 | |a Gene Knockout Techniques |2 MeSH |
| 650 | _ | 2 | |a Guanosine Diphosphate: metabolism |2 MeSH |
| 650 | _ | 2 | |a Models, Biological |2 MeSH |
| 650 | _ | 2 | |a Mutagenesis: genetics |2 MeSH |
| 650 | _ | 2 | |a Neuropeptides: metabolism |2 MeSH |
| 650 | _ | 2 | |a Phosphatidylinositol Phosphates: metabolism |2 MeSH |
| 650 | _ | 2 | |a Rats |2 MeSH |
| 650 | _ | 2 | |a Synaptic Vesicles: metabolism |2 MeSH |
| 650 | _ | 2 | |a Synaptic Vesicles: ultrastructure |2 MeSH |
| 650 | _ | 2 | |a Synaptophysin: metabolism |2 MeSH |
| 650 | _ | 2 | |a Vesicular Transport Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a rab5 GTP-Binding Proteins: metabolism |2 MeSH |
| 700 | 1 | _ | |a Schink, Kay Oliver |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Bruns, Christine |0 P:(DE-2719)2811027 |b 2 |u dzne |
| 700 | 1 | _ | |a Izsvák, Zsuzsanna |b 3 |
| 700 | 1 | _ | |a Hamra, F Kent |b 4 |
| 700 | 1 | _ | |a Rosenmund, Christian |b 5 |
| 700 | 1 | _ | |a Garner, Craig Curtis |0 P:(DE-2719)2810922 |b 6 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.7554/elife.46629 |b : eLife Sciences Publications, Ltd, 2019-05-10 |3 journal-article |2 Crossref |t eLife |v 8 |y 2019 |x 2050-084X |
| 773 | _ | _ | |a 10.7554/eLife.46629 |g Vol. 8, p. e46629 |0 PERI:(DE-600)2687154-3 |q 8 |t eLife |v 8 |y 2019 |x 2050-084X |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/140720/files/DZNE-2020-07042.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/140720/files/DZNE-2020-07042.pdf?subformat=pdfa |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541439 |
| 909 | C | O | |o oai:pub.dzne.de:140720 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2810967 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 2 |6 P:(DE-2719)2811027 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 6 |6 P:(DE-2719)2810922 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-341 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Molecular Signaling |x 0 |
| 914 | 1 | _ | |y 2019 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-23 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |d 2022-11-23 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ELIFE : 2021 |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2022-09-23T12:20:44Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2022-09-23T12:20:44Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-23 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-23 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b ELIFE : 2021 |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-23 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-23 |
| 920 | 1 | _ | |0 I:(DE-2719)1810001 |k AG Garner |l Synaptopathy |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1813004 |k AG Ackermann |l Astrocyte - Synapse Interactions |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1810001 |
| 980 | _ | _ | |a I:(DE-2719)1813004 |
| 980 | 1 | _ | |a FullTexts |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M009073200 |2 Crossref |o 10.1074/jbc.M009073200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.15252/embr.201540434 |2 Crossref |o 10.15252/embr.201540434 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.0000000000001523 |2 Crossref |o 10.1212/WNL.0000000000001523 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.0187-13.2013 |2 Crossref |o 10.1523/JNEUROSCI.0187-13.2013 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1152/physrev.00028.2012 |2 Crossref |o 10.1152/physrev.00028.2012 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/336185a0 |2 Crossref |o 10.1038/336185a0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/cercor/bhp170 |2 Crossref |o 10.1093/cercor/bhp170 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pone.0006529 |2 Crossref |o 10.1371/journal.pone.0006529 |
| 999 | C | 5 | |y 1996 |2 Crossref |o Cases-Langhoff 1996 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.biopsych.2010.09.042 |2 Crossref |o 10.1016/j.biopsych.2010.09.042 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/17618 |2 Crossref |o 10.1038/17618 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2014.02.012 |2 Crossref |o 10.1016/j.neuron.2014.02.012 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0896-6273(00)80883-1 |2 Crossref |o 10.1016/S0896-6273(00)80883-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M210792200 |2 Crossref |o 10.1074/jbc.M210792200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0736-5748(02)00046-1 |2 Crossref |o 10.1016/S0736-5748(02)00046-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/emboj/19.17.4577 |2 Crossref |o 10.1093/emboj/19.17.4577 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuroscience.2015.05.047 |2 Crossref |o 10.1016/j.neuroscience.2015.05.047 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.celrep.2013.10.039 |2 Crossref |o 10.1016/j.celrep.2013.10.039 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3389/fnsyn.2015.00019 |2 Crossref |o 10.3389/fnsyn.2015.00019 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1055/s-2002-20422 |2 Crossref |o 10.1055/s-2002-20422 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1083/jcb.150.3.589 |2 Crossref |o 10.1083/jcb.150.3.589 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.0712171105 |2 Crossref |o 10.1073/pnas.0712171105 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1083/jcb.57.2.315 |2 Crossref |o 10.1083/jcb.57.2.315 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1007037107 |2 Crossref |o 10.1073/pnas.1007037107 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0092-8674(00)80380-3 |2 Crossref |o 10.1016/S0092-8674(00)80380-3 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1109/MCSE.2007.55 |2 Crossref |o 10.1109/MCSE.2007.55 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M909309199 |2 Crossref |o 10.1074/jbc.M909309199 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nmeth.1461 |2 Crossref |o 10.1038/nmeth.1461 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1074/jbc.M212287200 |2 Crossref |o 10.1074/jbc.M212287200 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/gad.13.11.1475 |2 Crossref |o 10.1101/gad.13.11.1475 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1083/jcb.200711167 |2 Crossref |o 10.1083/jcb.200711167 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2007.10.032 |2 Crossref |o 10.1016/j.neuron.2007.10.032 |
| 999 | C | 5 | |y 2010 |2 Crossref |o McKinney 2010 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0960-9822(98)70018-1 |2 Crossref |o 10.1016/S0960-9822(98)70018-1 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/s0091-679x(03)01007-0 |2 Crossref |o 10.1016/s0091-679x(03)01007-0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/405985 |2 Crossref |o 10.1101/405985 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2011.08.029 |2 Crossref |o 10.1016/j.neuron.2011.08.029 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.jad.2012.01.028 |2 Crossref |o 10.1016/j.jad.2012.01.028 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pbio.1000136 |2 Crossref |o 10.1371/journal.pbio.1000136 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1000843107 |2 Crossref |o 10.1073/pnas.1000843107 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1073/pnas.1002307107 |2 Crossref |o 10.1073/pnas.1002307107 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.2038-18.2019 |2 Crossref |o 10.1523/JNEUROSCI.2038-18.2019 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature19326 |2 Crossref |o 10.1038/nature19326 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/srep27935 |2 Crossref |o 10.1038/srep27935 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neuron.2017.01.026 |2 Crossref |o 10.1016/j.neuron.2017.01.026 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.4161/sgtp.2.2.15201 |2 Crossref |o 10.4161/sgtp.2.2.15201 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrm1500 |2 Crossref |o 10.1038/nrm1500 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3389/fncel.2014.00259 |2 Crossref |o 10.3389/fncel.2014.00259 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.22-24-10680.2002 |2 Crossref |o 10.1523/JNEUROSCI.22-24-10680.2002 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/cshperspect.a005645 |2 Crossref |o 10.1101/cshperspect.a005645 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nmeth.2019 |2 Crossref |o 10.1038/nmeth.2019 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/bies.201300064 |2 Crossref |o 10.1002/bies.201300064 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1146/annurev-cellbio-111315-125349 |2 Crossref |o 10.1146/annurev-cellbio-111315-125349 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/415321a |2 Crossref |o 10.1038/415321a |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0896-6273(03)00667-6 |2 Crossref |o 10.1016/S0896-6273(03)00667-6 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/28879 |2 Crossref |o 10.1038/28879 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/380531a0 |2 Crossref |o 10.1038/380531a0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1515/BC.2009.056 |2 Crossref |o 10.1515/BC.2009.056 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/j.1460-2075.1994.tb06381.x |2 Crossref |o 10.1002/j.1460-2075.1994.tb06381.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/0092-8674(95)90120-5 |2 Crossref |o 10.1016/0092-8674(95)90120-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nrm2728 |2 Crossref |o 10.1038/nrm2728 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1101/cshperspect.a005637 |2 Crossref |o 10.1101/cshperspect.a005637 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/mp.2008.125 |2 Crossref |o 10.1038/mp.2008.125 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1254/fpj.119.163 |2 Crossref |o 10.1254/fpj.119.163 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pone.0167535 |2 Crossref |o 10.1371/journal.pone.0167535 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.cell.2011.02.039 |2 Crossref |o 10.1016/j.cell.2011.02.039 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0896-6273(03)00644-5 |2 Crossref |o 10.1016/S0896-6273(03)00644-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pone.0120093 |2 Crossref |o 10.1371/journal.pone.0120093 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1523/JNEUROSCI.1835-11.2011 |2 Crossref |o 10.1523/JNEUROSCI.1835-11.2011 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/emboj.2013.27 |2 Crossref |o 10.1038/emboj.2013.27 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1083/jcb.147.1.151 |2 Crossref |o 10.1083/jcb.147.1.151 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/nature12809 |2 Crossref |o 10.1038/nature12809 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1371/journal.pone.0061494 |2 Crossref |o 10.1371/journal.pone.0061494 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1083/jcb.200211087 |2 Crossref |o 10.1083/jcb.200211087 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1038/35052055 |2 Crossref |o 10.1038/35052055 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|