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000140732 041__ $$aEnglish
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000140732 1001_ $$0P:(DE-HGF)0$$aVogelgsang, Jonathan$$b0$$eCorresponding author
000140732 245__ $$aHigher Level of Mismatch in APOEε4 Carriers for Amyloid-Beta Peptide Alzheimer's Disease Biomarkers in Cerebrospinal Fluid.
000140732 260__ $$aLondon$$bSage Publishing$$c2019
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000140732 520__ $$aCerebrospinal fluid (CSF) biomarkers are widely used in the diagnosis of dementia. Even though there is a causal correlation between apolipoprotein E ( APOE) genotype and amyloid-beta (Aβ), the determination of APOE is currently not supported by national or international guidelines. We compared parallel measured CSF biomarkers of two independent laboratories from 126 patients who underwent clinical dementia diagnostics regarding the APOE genotype. APOE ε4 reduces Aβ1-42 (Aβ42) and Aβ42 to Aβ 1-40 ratio (Aβ42/40) but not total Tau or phospho-181 Tau CSF levels. Higher discordance rates were observed for Aβ42 and subsequently for Aβ42/40 in APOE ε4 carriers compared with noncarriers, and the correlation between the two laboratories was significantly lower for Aβ42 in APOE ε4 positive patients compared with patients without APOE ε4. These observations demonstrate that the evaluation of CSF Aβ biomarkers needs to be interpreted carefully in the clinical context. Different immunoassays, disparate cutoff values, and APOE should be respected.
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000140732 650_2 $$2MeSH$$aAged
000140732 650_2 $$2MeSH$$aAged, 80 and over
000140732 650_2 $$2MeSH$$aAlzheimer Disease: cerebrospinal fluid
000140732 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000140732 650_2 $$2MeSH$$aAmyloid beta-Protein Precursor: cerebrospinal fluid
000140732 650_2 $$2MeSH$$aApolipoproteins E: genetics
000140732 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000140732 650_2 $$2MeSH$$aFemale
000140732 650_2 $$2MeSH$$aGenotype
000140732 650_2 $$2MeSH$$aHeterozygote
000140732 650_2 $$2MeSH$$aHumans
000140732 650_2 $$2MeSH$$aMale
000140732 650_2 $$2MeSH$$aMiddle Aged
000140732 7001_ $$aVukovich, Ruth$$b1
000140732 7001_ $$aWedekind, Dirk$$b2
000140732 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b3$$eLast author$$udzne
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