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000140739 0247_ $$2doi$$a10.1016/j.stemcr.2019.04.020
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000140739 041__ $$aEnglish
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000140739 1001_ $$aPons-Espinal, Meritxell$$b0
000140739 245__ $$aMiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis.
000140739 260__ $$a[New York, NY]$$bElsevier$$c2019
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000140739 520__ $$aPhysical exercise stimulates adult hippocampal neurogenesis and is considered a relevant strategy for preventing age-related cognitive decline in humans. The underlying mechanisms remains controversial. Here, we show that exercise increases proliferation of neural precursor cells (NPCs) of the mouse dentate gyrus (DG) via downregulation of microRNA 135a-5p (miR-135a). MiR-135a inhibition stimulates NPC proliferation leading to increased neurogenesis, but not astrogliogenesis, in DG of resting mice, and intriguingly it re-activates NPC proliferation in aged mice. We identify 17 proteins (11 putative targets) modulated by miR-135 in NPCs. Of note, inositol 1,4,5-trisphosphate (IP3) receptor 1 and inositol polyphosphate-4-phosphatase type I are among the modulated proteins, suggesting that IP3 signaling may act downstream miR-135. miR-135 is the first noncoding RNA essential modulator of the brain's response to physical exercise. Prospectively, the miR-135-IP3 axis might represent a novel target of therapeutic intervention to prevent pathological brain aging.
000140739 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000140739 542__ $$2Crossref$$i2019-06-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000140739 542__ $$2Crossref$$i2019-04-25$$uhttp://creativecommons.org/licenses/by-nc-nd/4.0/
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000140739 650_2 $$2MeSH$$aAdult Stem Cells: metabolism
000140739 650_2 $$2MeSH$$aAging: metabolism
000140739 650_2 $$2MeSH$$aAnimals
000140739 650_2 $$2MeSH$$aCell Proliferation
000140739 650_2 $$2MeSH$$aGene Expression Regulation
000140739 650_2 $$2MeSH$$aHumans
000140739 650_2 $$2MeSH$$aIntercellular Signaling Peptides and Proteins: biosynthesis
000140739 650_2 $$2MeSH$$aIntracellular Signaling Peptides and Proteins: biosynthesis
000140739 650_2 $$2MeSH$$aLateral Ventricles: cytology
000140739 650_2 $$2MeSH$$aLateral Ventricles: metabolism
000140739 650_2 $$2MeSH$$aMice
000140739 650_2 $$2MeSH$$aMice, Knockout
000140739 650_2 $$2MeSH$$aMicroRNAs: biosynthesis
000140739 650_2 $$2MeSH$$aNeural Stem Cells: metabolism
000140739 650_2 $$2MeSH$$aNeurogenesis
000140739 650_2 $$2MeSH$$aPhysical Conditioning, Animal
000140739 650_2 $$2MeSH$$aStem Cell Niche
000140739 650_2 $$2MeSH$$ap38 Mitogen-Activated Protein Kinases: biosynthesis
000140739 7001_ $$aGasperini, Caterina$$b1
000140739 7001_ $$aMarzi, Matteo J$$b2
000140739 7001_ $$aBraccia, Clarissa$$b3
000140739 7001_ $$aArmirotti, Andrea$$b4
000140739 7001_ $$0P:(DE-2719)2810879$$aPötzsch, Alexandra$$b5$$udzne
000140739 7001_ $$0P:(DE-2719)9000335$$aWalker, Tara L$$b6$$udzne
000140739 7001_ $$0P:(DE-2719)2000006$$aFabel, Klaus$$b7$$udzne
000140739 7001_ $$aNicassio, Francesco$$b8
000140739 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b9$$udzne
000140739 7001_ $$0P:(DE-HGF)0$$aDe Pietri Tonelli, Davide$$b10$$eCorresponding author
000140739 77318 $$2Crossref$$3journal-article$$a10.1016/j.stemcr.2019.04.020$$b : Elsevier BV, 2019-06-01$$n6$$p1298-1312$$tStem Cell Reports$$v12$$x2213-6711$$y2019
000140739 773__ $$0PERI:(DE-600)2720528-9$$a10.1016/j.stemcr.2019.04.020$$gVol. 12, no. 6, p. 1298 - 1312$$n6$$p1298-1312$$q12:6<1298 - 1312$$tStem cell reports$$v12$$x2213-6711$$y2019
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000140739 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565832
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