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@ARTICLE{PonsEspinal:140739,
      author       = {Pons-Espinal, Meritxell and Gasperini, Caterina and Marzi,
                      Matteo J and Braccia, Clarissa and Armirotti, Andrea and
                      Pötzsch, Alexandra and Walker, Tara L and Fabel, Klaus and
                      Nicassio, Francesco and Kempermann, Gerd and De Pietri
                      Tonelli, Davide},
      title        = {{M}i{R}-135a-5p {I}s {C}ritical for {E}xercise-{I}nduced
                      {A}dult {N}eurogenesis.},
      journal      = {Stem cell reports},
      volume       = {12},
      number       = {6},
      issn         = {2213-6711},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-07061},
      pages        = {1298-1312},
      year         = {2019},
      abstract     = {Physical exercise stimulates adult hippocampal neurogenesis
                      and is considered a relevant strategy for preventing
                      age-related cognitive decline in humans. The underlying
                      mechanisms remains controversial. Here, we show that
                      exercise increases proliferation of neural precursor cells
                      (NPCs) of the mouse dentate gyrus (DG) via downregulation of
                      microRNA 135a-5p (miR-135a). MiR-135a inhibition stimulates
                      NPC proliferation leading to increased neurogenesis, but not
                      astrogliogenesis, in DG of resting mice, and intriguingly it
                      re-activates NPC proliferation in aged mice. We identify 17
                      proteins (11 putative targets) modulated by miR-135 in NPCs.
                      Of note, inositol 1,4,5-trisphosphate (IP3) receptor 1 and
                      inositol polyphosphate-4-phosphatase type I are among the
                      modulated proteins, suggesting that IP3 signaling may act
                      downstream miR-135. miR-135 is the first noncoding RNA
                      essential modulator of the brain's response to physical
                      exercise. Prospectively, the miR-135-IP3 axis might
                      represent a novel target of therapeutic intervention to
                      prevent pathological brain aging.},
      keywords     = {Adult Stem Cells: metabolism / Aging: metabolism / Animals
                      / Cell Proliferation / Gene Expression Regulation / Humans /
                      Intercellular Signaling Peptides and Proteins: biosynthesis
                      / Intracellular Signaling Peptides and Proteins:
                      biosynthesis / Lateral Ventricles: cytology / Lateral
                      Ventricles: metabolism / Mice / Mice, Knockout / MicroRNAs:
                      biosynthesis / Neural Stem Cells: metabolism / Neurogenesis
                      / Physical Conditioning, Animal / Stem Cell Niche / p38
                      Mitogen-Activated Protein Kinases: biosynthesis},
      cin          = {AG Kempermann / Dresden common},
      ddc          = {610},
      cid          = {I:(DE-2719)1710001 / I:(DE-2719)6000013},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31130358},
      pmc          = {pmc:PMC6565832},
      doi          = {10.1016/j.stemcr.2019.04.020},
      url          = {https://pub.dzne.de/record/140739},
}