Home > Publications Database > MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis. > print

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024 7 _ |a 10.1016/j.stemcr.2019.04.020
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037 _ _ |a DZNE-2020-07061
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Pons-Espinal, Meritxell
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245 _ _ |a MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis.
260 _ _ |a [New York, NY]
|c 2019
|b Elsevier
264 _ 1 |3 print
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|b Elsevier BV
|c 2019-06-01
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Physical exercise stimulates adult hippocampal neurogenesis and is considered a relevant strategy for preventing age-related cognitive decline in humans. The underlying mechanisms remains controversial. Here, we show that exercise increases proliferation of neural precursor cells (NPCs) of the mouse dentate gyrus (DG) via downregulation of microRNA 135a-5p (miR-135a). MiR-135a inhibition stimulates NPC proliferation leading to increased neurogenesis, but not astrogliogenesis, in DG of resting mice, and intriguingly it re-activates NPC proliferation in aged mice. We identify 17 proteins (11 putative targets) modulated by miR-135 in NPCs. Of note, inositol 1,4,5-trisphosphate (IP3) receptor 1 and inositol polyphosphate-4-phosphatase type I are among the modulated proteins, suggesting that IP3 signaling may act downstream miR-135. miR-135 is the first noncoding RNA essential modulator of the brain's response to physical exercise. Prospectively, the miR-135-IP3 axis might represent a novel target of therapeutic intervention to prevent pathological brain aging.
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542 _ _ |i 2019-06-01
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|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2019-04-25
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|u http://creativecommons.org/licenses/by-nc-nd/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Adult Stem Cells: metabolism
|2 MeSH
650 _ 2 |a Aging: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Cell Proliferation
|2 MeSH
650 _ 2 |a Gene Expression Regulation
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Intercellular Signaling Peptides and Proteins: biosynthesis
|2 MeSH
650 _ 2 |a Intracellular Signaling Peptides and Proteins: biosynthesis
|2 MeSH
650 _ 2 |a Lateral Ventricles: cytology
|2 MeSH
650 _ 2 |a Lateral Ventricles: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a MicroRNAs: biosynthesis
|2 MeSH
650 _ 2 |a Neural Stem Cells: metabolism
|2 MeSH
650 _ 2 |a Neurogenesis
|2 MeSH
650 _ 2 |a Physical Conditioning, Animal
|2 MeSH
650 _ 2 |a Stem Cell Niche
|2 MeSH
650 _ 2 |a p38 Mitogen-Activated Protein Kinases: biosynthesis
|2 MeSH
700 1 _ |a Gasperini, Caterina
|b 1
700 1 _ |a Marzi, Matteo J
|b 2
700 1 _ |a Braccia, Clarissa
|b 3
700 1 _ |a Armirotti, Andrea
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700 1 _ |a Pötzsch, Alexandra
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700 1 _ |a Walker, Tara L
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700 1 _ |a Fabel, Klaus
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700 1 _ |a Nicassio, Francesco
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700 1 _ |a Kempermann, Gerd
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700 1 _ |a De Pietri Tonelli, Davide
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773 1 8 |a 10.1016/j.stemcr.2019.04.020
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|t Stem Cell Reports
|v 12
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773 _ _ |a 10.1016/j.stemcr.2019.04.020
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