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@ARTICLE{Erdur:140772,
      author       = {Erdur, H. and Siegerink, B. and Ganeshan, R. and Audebert,
                      H. J. and Endres, M. and Nolte, C. H. and Scheitz, J. F.},
      title        = {{M}yocardial injury in transient global amnesia: a
                      case-control study.},
      journal      = {European journal of neurology},
      volume       = {26},
      number       = {7},
      issn         = {1351-5101},
      address      = {Oxford},
      publisher    = {Blackwell Science78889},
      reportid     = {DZNE-2020-07094},
      pages        = {986-991},
      year         = {2019},
      abstract     = {Elevation of cardiac troponin (cTn), a sensitive biomarker
                      of myocardial injury, is frequently observed in severe acute
                      neurological disorders. Case reports suggest that cardiac
                      dysfunction may also occur in patients with transient global
                      amnesia (TGA). Until now, no study has systematically
                      assessed this phenomenon.We performed a case-control study
                      using data of consecutive patients presenting with TGA from
                      2010 to 2015. Multiple logistic regression analysis
                      accounting for age, sex and cardiovascular risk factors was
                      performed to compare the likelihood of myocardial injury
                      [defined as elevation of cTn > 99th percentile
                      (≥14 ng/L); highly sensitive cardiac troponin T assay] in
                      TGA with three reference groups: migraine with aura,
                      vestibular neuritis and transient ischaemic attack
                      (TIA).Cardiac troponin elevation occurred in 28 $(25\%)$ of
                      113 patients with TGA. Patients with TGA with cTn elevation
                      were significantly older, more likely to be female and had
                      higher blood pressure on admission compared with those
                      without. The likelihood of myocardial injury following TGA
                      was at least more than twofold higher compared with all
                      three reference groups [adjusted odds ratio, 5.5; $95\%$
                      confidence interval (CI), 1.2-26.4, compared with migraine
                      with aura; adjusted odds ratio, 2.2; $95\%$ CI, 1.2-4.4,
                      compared with vestibular neuritis; adjusted odds ratio, 2.3;
                      $95\%$ CI, 1.3-4.2, compared with TIA].One out of four
                      patients with TGA had evidence of myocardial injury as
                      assessed by highly sensitive cTn assays. The likelihood of
                      myocardial injury associated with TGA was even higher than
                      in TIA patients with a more pronounced cardiovascular risk
                      profile. Our findings suggest the presence of a TGA-related
                      disturbance of brain-heart interaction that deserves further
                      investigation.},
      keywords     = {Aged / Aged, 80 and over / Amnesia, Transient Global: blood
                      / Amnesia, Transient Global: complications / Case-Control
                      Studies / Female / Heart Diseases: blood / Heart Diseases:
                      complications / Humans / Ischemic Attack, Transient: blood /
                      Ischemic Attack, Transient: complications / Male / Middle
                      Aged / Migraine Disorders: blood / Migraine Disorders:
                      complications / Risk Factors / Troponin T: blood},
      cin          = {AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005},
      pnm          = {899H - Addenda (POF3-899H)},
      pid          = {G:(DE-HGF)POF3-899H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30706590},
      doi          = {10.1111/ene.13920},
      url          = {https://pub.dzne.de/record/140772},
}