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000140809 0247_ $$2doi$$a10.1007/s00259-019-04342-3
000140809 0247_ $$2pmid$$apmid:31183635
000140809 0247_ $$2ISSN$$a0340-6997
000140809 0247_ $$2ISSN$$a1432-105X
000140809 0247_ $$2ISSN$$a1619-7070
000140809 0247_ $$2ISSN$$a1619-7089
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000140809 037__ $$aDZNE-2020-07131
000140809 041__ $$aEnglish
000140809 082__ $$a610
000140809 1001_ $$0P:(DE-HGF)0$$aHoenig, Merle C$$b0$$eCorresponding author
000140809 245__ $$aLevel of education mitigates the impact of tau pathology on neuronal function.
000140809 260__ $$aHeidelberg [u.a.]$$bSpringer-Verl.$$c2019
000140809 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2019-06-10
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000140809 520__ $$aUsing PET imaging in a group of patients with Alzheimer's disease (AD), we investigated whether level of education, a proxy for resilience, mitigates the harmful impact of tau pathology on neuronal function.We included 38 patients with mild-to-moderate AD (mean age 67 ± 7 years, mean MMSE score 24 ± 4, mean years of education 14 ± 4; 20 men, 18 women) in whom a [18F]AV-1451 scan (a measure of tau pathology) and an [18F]FDG scan (a measure of neuronal function) were available. The preprocessed PET scans were z-transformed using templates for [18F]AV-1451 and [18F]FDG from healthy controls, and subsequently thresholded at a z-score of ≥3.0, representing an one-tailed p value of 0.001. Next, three volumes were computed in each patient: the tau-specific volume (tau pathology without neuronal dysfunction), the FDG-specific volume (neuronal dysfunction without tau pathology), and the overlap volume (tau pathology and neuronal dysfunction). Mean z-scores and volumes were extracted and used as dependent variables in regression analysis with years of education as predictor, and age and MMSE score as covariates.Years of education were positively associated with tau-specific volume (β = 0.362, p = 0.022), suggesting a lower impact of tau pathology on neuronal function in patients with higher levels of education. Concomitantly, level of education was positively related to tau burden in the overlap volume (β = 0.303, p = 0.036) implying that with higher levels of education more tau pathology is necessary to induce neuronal dysfunction.In patients with higher levels of education, tau pathology is less paralleled by regional and remote neuronal dysfunction. The data suggest that early life-time factors such as level of education support resilience mechanisms, which ameliorate AD-related effects later in life.
000140809 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000140809 542__ $$2Crossref$$i2019-06-10$$uhttp://www.springer.com/tdm
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000140809 650_2 $$2MeSH$$aAged
000140809 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000140809 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000140809 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000140809 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000140809 650_2 $$2MeSH$$aEducational Status
000140809 650_2 $$2MeSH$$aFemale
000140809 650_2 $$2MeSH$$aHumans
000140809 650_2 $$2MeSH$$aMale
000140809 650_2 $$2MeSH$$aNeurons: pathology
000140809 650_2 $$2MeSH$$aPositron-Emission Tomography
000140809 650_2 $$2MeSH$$atau Proteins: metabolism
000140809 7001_ $$0P:(DE-HGF)0$$aBischof, Gérard N$$b1
000140809 7001_ $$0P:(DE-HGF)0$$aOnur, Özgür A$$b2
000140809 7001_ $$0P:(DE-HGF)0$$aKukolja, Juraj$$b3
000140809 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b4$$udzne
000140809 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b5$$udzne
000140809 7001_ $$0P:(DE-HGF)0$$aNeumaier, Bernd$$b6
000140809 7001_ $$0P:(DE-HGF)0$$aFink, Gereon R$$b7
000140809 7001_ $$0P:(DE-HGF)0$$aKalbe, Elke$$b8
000140809 7001_ $$0P:(DE-2719)2811239$$aDrzezga, Alexander$$b9$$udzne
000140809 7001_ $$0P:(DE-2719)2812285$$aEimeren, Thilo$$b10$$eLast author$$udzne
000140809 7001_ $$0P:(DE-HGF)0$$aInitiative, Alzheimer’s Disease Neuroimaging$$b11
000140809 77318 $$2Crossref$$3journal-article$$a10.1007/s00259-019-04342-3$$b : Springer Science and Business Media LLC, 2019-06-10$$n9$$p1787-1795$$tEuropean Journal of Nuclear Medicine and Molecular Imaging$$v46$$x1619-7070$$y2019
000140809 773__ $$0PERI:(DE-600)2098375-X$$a10.1007/s00259-019-04342-3$$gVol. 46, no. 9, p. 1787 - 1795$$n9$$p1787-1795$$q46:9<1787 - 1795$$tEuropean journal of nuclear medicine and molecular imaging$$v46$$x1619-7070$$y2019
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000140809 9141_ $$y2019
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000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/acn3.339$$o10.1002/acn3.339
000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/scitranslmed.aaf2362$$o10.1126/scitranslmed.aaf2362
000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/brain/awx243$$o10.1093/brain/awx243
000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2018.02.020$$o10.1016/j.jalz.2018.02.020
000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3233/JAD-160316$$o10.3233/JAD-160316
000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1017/S1355617702813248$$o10.1017/S1355617702813248
000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2018.07.219$$o10.1016/j.jalz.2018.07.219
000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s11682-016-9566-x$$o10.1007/s11682-016-9566-x
000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tics.2012.04.005$$o10.1016/j.tics.2012.04.005
000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2017.05.004$$o10.1016/j.neurobiolaging.2017.05.004
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000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1474-4422(12)70291-0$$o10.1016/S1474-4422(12)70291-0
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000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/ana.21212$$o10.1002/ana.21212
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000140809 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2012.08.019$$o10.1016/j.neuron.2012.08.019
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