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000140868 1001_ $$aKeute, Marius$$b0
000140868 245__ $$aNo modulation of pupil size and event-related pupil response by transcutaneous auricular vagus nerve stimulation (taVNS).
000140868 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2019
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000140868 520__ $$aTranscutaneous auricular vagus nerve stimulation (taVNS) bears therapeutic potential for a wide range of medical conditions. However, previous studies have found substantial interindividual variability in responsiveness to taVNS, and no reliable predictive biomarker for stimulation success has been developed so far. In this study, we investigate pupil size and event-related pupil response as candidate biomarkers. Both measures have a direct physiological link to the activity of the locus coeruleus (LC), a brainstem structure and the main source of norepinephrine in the brain. LC activation is considered one of the key mechanisms of action of taVNS, therefore, we expected a clear increase of the pupillary measures under taVNS compared to sham (placebo) stimulation, such that it could serve as a prospective predictor for individual clinical and physiological taVNS effects in future studies. We studied resting pupil size and pupillary responses to target stimuli in an auditory oddball task in 33 healthy young volunteers. We observed stronger pupil responses to target than to standard stimuli. However, and contrary to our hypothesis, neither pupil size nor the event-related pupil response nor behavioral performance were modulated by taVNS. We discuss potential explanations for this negative finding and its implications for future clinical investigation and development of taVNS.
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000140868 650_2 $$2MeSH$$aAdult
000140868 650_2 $$2MeSH$$aDepression: therapy
000140868 650_2 $$2MeSH$$aEar Auricle: innervation
000140868 650_2 $$2MeSH$$aElectrodes
000140868 650_2 $$2MeSH$$aEpilepsy: therapy
000140868 650_2 $$2MeSH$$aFemale
000140868 650_2 $$2MeSH$$aHealthy Volunteers
000140868 650_2 $$2MeSH$$aHumans
000140868 650_2 $$2MeSH$$aLocus Coeruleus: physiology
000140868 650_2 $$2MeSH$$aMale
000140868 650_2 $$2MeSH$$aPupil: physiology
000140868 650_2 $$2MeSH$$aSkin: innervation
000140868 650_2 $$2MeSH$$aTranscutaneous Electric Nerve Stimulation: instrumentation
000140868 650_2 $$2MeSH$$aTranscutaneous Electric Nerve Stimulation: methods
000140868 650_2 $$2MeSH$$aVagus Nerve: physiology
000140868 650_2 $$2MeSH$$aVagus Nerve Stimulation: instrumentation
000140868 650_2 $$2MeSH$$aVagus Nerve Stimulation: methods
000140868 650_2 $$2MeSH$$aYoung Adult
000140868 7001_ $$aDemirezen, Mustafa$$b1
000140868 7001_ $$0P:(DE-2719)2811346$$aGraf, Alina$$b2$$udzne
000140868 7001_ $$0P:(DE-2719)2191623$$aMüller, Notger$$b3$$udzne
000140868 7001_ $$0P:(DE-HGF)0$$aZaehle, Tino$$b4$$eCorresponding author
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