Home > Publications Database > Neuronal spiking in the pedunculopontine nucleus in progressive supranuclear palsy and in idiopathic Parkinson's disease. > print

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005     20240321220908.0
024 7 _ |a 0367-004x
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037 _ _ |a DZNE-2020-07201
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Galazky, I.
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245 _ _ |a Neuronal spiking in the pedunculopontine nucleus in progressive supranuclear palsy and in idiopathic Parkinson's disease.
260 _ _ |a Berlin
|c 2019
|b Springer73057
264 _ 1 |3 online
|2 Crossref
|b Springer Science and Business Media LLC
|c 2019-06-03
264 _ 1 |3 print
|2 Crossref
|b Springer Science and Business Media LLC
|c 2019-09-01
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a The pedunculopontine nucleus (PPN) is engaged in posture and gait control, and neuronal degeneration in the PPN has been associated with Parkinsonian disorders. Clinical outcomes of deep brain stimulation of the PPN in idiopathic Parkinson's disease (IPD) and progressive supranuclear palsy (PSP) differ, and we investigated whether the PPN is differentially affected in these conditions. We had the rare opportunity to record continuous electrophysiological data intraoperatively in 30 s blocks from single microelectrode contacts implanted in the PPN in six PSP patients and three IPD patients during rest, passive movement, and active movement. Neuronal spikes were sorted according to shape using a wavelet-based clustering approach to enable comparisons between individual neuronal firing rates in the two disease states. The action potential widths showed a bimodal distribution consistent with previous findings, suggesting spikes from noncholinergic (likely glutamatergic) and cholinergic neurons. A higher PPN spiking rate of narrow action potentials was observed in the PSP than in the IPD patients when pooled across all three conditions (Wilcoxon rank sum test: p = 0.0141). No correlation was found between firing rate and disease severity or duration. The firing rates were higher during passive movement than rest and active movement in both groups, but the differences between conditions were not significant. PSP and IPD are believed to represent distinct disease processes, and our findings that the neuronal firing rates differ according to disease state support the proposal that pathological processes directly involving the PPN may be more pronounced in PSP than IPD.
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542 _ _ |i 2019-06-03
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650 _ 2 |a Action Potentials: physiology
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Cohort Studies
|2 MeSH
650 _ 2 |a Electrodes, Implanted
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Intraoperative Neurophysiological Monitoring: instrumentation
|2 MeSH
650 _ 2 |a Intraoperative Neurophysiological Monitoring: methods
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
650 _ 2 |a Parkinson Disease: diagnosis
|2 MeSH
650 _ 2 |a Parkinson Disease: physiopathology
|2 MeSH
650 _ 2 |a Parkinson Disease: surgery
|2 MeSH
650 _ 2 |a Pedunculopontine Tegmental Nucleus: physiology
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: diagnosis
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: physiopathology
|2 MeSH
650 _ 2 |a Supranuclear Palsy, Progressive: surgery
|2 MeSH
700 1 _ |a Kaufmann, J.
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700 1 _ |a Voges, J.
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700 1 _ |a Hinrichs, H.
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700 1 _ |a Sweeney-Reed, C. M.
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773 1 8 |a 10.1007/s00415-019-09396-9
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|t Journal of Neurology
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773 _ _ |a 10.1007/s00415-019-09396-9
|g Vol. 266, no. 9, p. 2244 - 2251
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