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000140922 0247_ $$2doi$$a10.1007/s12035-018-1444-7
000140922 0247_ $$2pmid$$apmid:30539330
000140922 0247_ $$2pmc$$apmc:PMC6647430
000140922 0247_ $$2ISSN$$a0893-7648
000140922 0247_ $$2ISSN$$a1559-1182
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000140922 037__ $$aDZNE-2020-07244
000140922 041__ $$aEnglish
000140922 082__ $$a570
000140922 1001_ $$aWeise, Stefan C$$b0
000140922 245__ $$aFOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus.
000140922 260__ $$aTotowa, NJ$$bHumana Press$$c2019
000140922 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2018-12-11
000140922 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2019-07-01
000140922 3367_ $$2DRIVER$$aarticle
000140922 3367_ $$2DataCite$$aOutput Types/Journal article
000140922 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1591185830_20666
000140922 3367_ $$2BibTeX$$aARTICLE
000140922 3367_ $$2ORCID$$aJOURNAL_ARTICLE
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000140922 520__ $$aRett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between progenitor proliferation and neuronal differentiation. Using genome-wide small RNA sequencing and quantitative proteomics, we identified that FOXG1 affects the biogenesis of miR200b/a/429 and interacts with the ATP-dependent RNA helicase, DDX5/p68. Both FOXG1 and DDX5 associate with the microprocessor complex, whereby DDX5 recruits FOXG1 to DROSHA. RNA-Seq analyses of Foxg1cre/+ hippocampi and N2a cells overexpressing miR200 family members identified cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) as a target of miR200 in neural cells. PRKAR2B inhibits postsynaptic functions by attenuating protein kinase A (PKA) activity; thus, increased PRKAR2B levels may contribute to neuronal dysfunctions in FOXG1 syndrome. Our data suggest that FOXG1 regulates PRKAR2B expression both on transcriptional and posttranscriptional levels.
000140922 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000140922 542__ $$2Crossref$$i2018-12-11$$uhttps://creativecommons.org/licenses/by/4.0
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000140922 650_7 $$2NLM Chemicals$$aCyclic AMP-Dependent Protein Kinase RIIbeta Subunit
000140922 650_7 $$2NLM Chemicals$$aForkhead Transcription Factors
000140922 650_7 $$2NLM Chemicals$$aFoxg1 protein, mouse
000140922 650_7 $$2NLM Chemicals$$aMicroRNAs
000140922 650_7 $$2NLM Chemicals$$aMirn200 microRNA, mouse
000140922 650_7 $$2NLM Chemicals$$aNerve Tissue Proteins
000140922 650_7 $$2NLM Chemicals$$aPRKAR2B protein, human
000140922 650_2 $$2MeSH$$aAge Factors
000140922 650_2 $$2MeSH$$aAnimals
000140922 650_2 $$2MeSH$$aCyclic AMP-Dependent Protein Kinase RIIbeta Subunit: genetics
000140922 650_2 $$2MeSH$$aCyclic AMP-Dependent Protein Kinase RIIbeta Subunit: metabolism
000140922 650_2 $$2MeSH$$aForkhead Transcription Factors: genetics
000140922 650_2 $$2MeSH$$aForkhead Transcription Factors: metabolism
000140922 650_2 $$2MeSH$$aHippocampus: growth & development
000140922 650_2 $$2MeSH$$aHippocampus: metabolism
000140922 650_2 $$2MeSH$$aMice
000140922 650_2 $$2MeSH$$aMice, Inbred C57BL
000140922 650_2 $$2MeSH$$aMice, Transgenic
000140922 650_2 $$2MeSH$$aMicroRNAs: genetics
000140922 650_2 $$2MeSH$$aMicroRNAs: metabolism
000140922 650_2 $$2MeSH$$aNerve Tissue Proteins: genetics
000140922 650_2 $$2MeSH$$aNerve Tissue Proteins: metabolism
000140922 650_2 $$2MeSH$$aTranscription, Genetic: physiology
000140922 7001_ $$aArumugam, Ganeshkumar$$b1
000140922 7001_ $$aVillarreal, Alejandro$$b2
000140922 7001_ $$aVidem, Pavankumar$$b3
000140922 7001_ $$aHeidrich, Stefanie$$b4
000140922 7001_ $$aNebel, Nils$$b5
000140922 7001_ $$aDumit, Verónica I$$b6
000140922 7001_ $$0P:(DE-2719)2811099$$aSananbenesi, Farahnaz$$b7$$udzne
000140922 7001_ $$aReimann, Viktoria$$b8
000140922 7001_ $$aCraske, Madeline$$b9
000140922 7001_ $$aSchilling, Oliver$$b10
000140922 7001_ $$aHess, Wolfgang R$$b11
000140922 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b12$$udzne
000140922 7001_ $$aBackofen, Rolf$$b13
000140922 7001_ $$0P:(DE-HGF)0$$aVogel, Tanja$$b14$$eCorresponding author
000140922 77318 $$2Crossref$$3journal-article$$a10.1007/s12035-018-1444-7$$b : Springer Science and Business Media LLC, 2018-12-11$$n7$$p5188-5201$$tMolecular Neurobiology$$v56$$x0893-7648$$y2018
000140922 773__ $$0PERI:(DE-600)2079384-4$$a10.1007/s12035-018-1444-7$$gVol. 56, no. 7, p. 5188 - 5201$$n7$$p5188-5201$$q56:7<5188 - 5201$$tMolecular neurobiology$$v56$$x0893-7648$$y2018
000140922 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647430
000140922 909CO $$ooai:pub.dzne.de:140922$$pVDB
000140922 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811099$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000140922 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000047$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000140922 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000140922 9141_ $$y2019
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000140922 9201_ $$0I:(DE-2719)1440012$$kAG Bonn 2$$lComputational Systems Biology$$x0
000140922 9201_ $$0I:(DE-2719)1410002$$kAG Fischer 1$$lEpigenetics and Systems Medicine in Neurodegenerative Diseases$$x1
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