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@ARTICLE{Kaczmarczyk:140925,
      author       = {Kaczmarczyk, Lech and Bansal, Vikas and Rajput, Ashish and
                      Rahman, Raza-Ur and Krzyżak, Wiesław and Degen, Joachim
                      and Poll, Stefanie and Fuhrmann, Martin and Bonn, Stefan and
                      Jackson, Walker Scot},
      title        = {{T}agger-{A} {S}wiss army knife for multiomics to dissect
                      cell type-specific mechanisms of gene expression in mice.},
      journal      = {PLoS biology},
      volume       = {17},
      number       = {8},
      issn         = {1545-7885},
      address      = {Lawrence, KS},
      publisher    = {PLoS},
      reportid     = {DZNE-2020-07247},
      pages        = {e3000374},
      year         = {2019},
      abstract     = {A deep understanding of how regulation of the multiple
                      levels of gene expression in mammalian tissues give rise to
                      complex phenotypes has been impeded by cellular diversity. A
                      handful of techniques were developed to tag-select nucleic
                      acids of interest in specific cell types, thereby enabling
                      their capture. We expanded this strategy by developing the
                      Tagger knock-in mouse line bearing a quad-cistronic
                      transgene combining enrichment tools for nuclei, nascent
                      RNA, translating mRNA, and mature microRNA (miRNA). We
                      demonstrate that Tagger can capture the desired nucleic
                      acids, enabling multiple omics approaches to be applied to
                      specific cell types in vivo using a single transgenic mouse
                      line.},
      keywords     = {Animals / Cloning, Molecular: methods / Gene Expression:
                      genetics / Gene Expression Profiling: methods / Gene
                      Expression Regulation: genetics / Gene Knock-In Techniques /
                      Genomics: methods / Mice / Mice, Inbred C57BL / Mice,
                      Transgenic: genetics / MicroRNAs: genetics / Nucleic Acids:
                      isolation $\&$ purification / Proteomics: methods / RNA,
                      Messenger: genetics / Transcriptome: genetics / Transgenes:
                      genetics / Whole Genome Sequencing: methods},
      cin          = {AG Jackson / AG Fuhrmann / AG Bonn 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1013019 / I:(DE-2719)1011004 /
                      I:(DE-2719)1410003},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31393866},
      pmc          = {pmc:PMC6701817},
      doi          = {10.1371/journal.pbio.3000374},
      url          = {https://pub.dzne.de/record/140925},
}