TY  - JOUR
AU  - Shine, Jonathan
AU  - Valdes Herrera, Jose Pedro
AU  - Tempelmann, C.
AU  - Wolbers, T.
TI  - Evidence for allocentric boundary and goal direction information in the human entorhinal cortex and subiculum.
JO  - Nature Communications
VL  - 10
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DZNE-2020-07258
SP  - 4004
PY  - 2019
AB  - In rodents, cells in the medial entorhinal cortex (EC) and subiculum code for the allocentric direction to environment boundaries, which is an important prerequisite for accurate positional coding. Although in humans boundary-related signals have been reported, there is no evidence that they contain allocentric direction information. Furthermore, it has not been possible to separate boundary versus goal direction signals in the EC/subiculum. Here, to address these questions, we had participants learn a virtual environment containing four unique boundaries. Participants then underwent fMRI scanning where they made judgements about the allocentric direction of a cue object. Using multivariate decoding, we found information regarding allocentric boundary direction in posterior EC and subiculum, whereas allocentric goal direction was decodable from anterior EC and subiculum. These data provide the first evidence of allocentric boundary coding in humans, and are consistent with recent conceptualisations of a division of labour within the EC.
KW  - Adult
KW  - Entorhinal Cortex: physiology
KW  - Environment
KW  - Female
KW  - Hippocampus: physiology
KW  - Humans
KW  - Learning: physiology
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Memory: physiology
KW  - Spatial Navigation
KW  - Temporal Lobe
KW  - Vision Disparity: physiology
KW  - Visual Perception: physiology
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:31488828
C2  - pmc:PMC6728372
DO  - DOI:10.1038/s41467-019-11802-9
UR  - https://pub.dzne.de/record/140936
ER  -