TY  - JOUR
AU  - Smith, Eric E
AU  - Biessels, Geert Jan
AU  - De Guio, François
AU  - de Leeuw, Frank Erik
AU  - Duchesne, Simon
AU  - Düring, Marco
AU  - Frayne, Richard
AU  - Ikram, M Arfan
AU  - Jouvent, Eric
AU  - MacIntosh, Bradley J
AU  - Thrippleton, Michael J
AU  - Vernooij, Meike W
AU  - Adams, Hieab
AU  - Backes, Walter H
AU  - Ballerini, Lucia
AU  - Black, Sandra E
AU  - Chen, Christopher
AU  - Corriveau, Rod
AU  - DeCarli, Charles
AU  - Greenberg, Steven M
AU  - Gurol, M Edip
AU  - Ingrisch, Michael
AU  - Job, Dominic
AU  - Lam, Bonnie Y K
AU  - Launer, Lenore J
AU  - Linn, Jennifer
AU  - McCreary, Cheryl R
AU  - Mok, Vincent C T
AU  - Pantoni, Leonardo
AU  - Pike, G Bruce
AU  - Ramirez, Joel
AU  - Reijmer, Yael D
AU  - Romero, Jose Rafael
AU  - Ropele, Stefan
AU  - Rost, Natalia S
AU  - Sachdev, Perminder S
AU  - Scott, Christopher J M
AU  - Seshadri, Sudha
AU  - Sharma, Mukul
AU  - Sourbron, Steven
AU  - Steketee, Rebecca M E
AU  - Swartz, Richard H
AU  - van Oostenbrugge, Robert
AU  - van Osch, Matthias
AU  - van Rooden, Sanneke
AU  - Viswanathan, Anand
AU  - Werring, David
AU  - Dichgans, Martin
AU  - Wardlaw, Joanna M
TI  - Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration.
JO  - Alzheimer's & dementia / Diagnosis, assessment & disease  monitoring
VL  - 11
IS  - 1
SN  - 2352-8729
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2020-07375
SP  - 191-204
PY  - 2019
AB  - Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.Surveys, teleconferences, and an in-person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.A framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created at www.harness-neuroimaging.org with acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.The HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.
LB  - PUB:(DE-HGF)16
C6  - pmid:30859119
C2  - pmc:PMC6396326
DO  - DOI:10.1016/j.dadm.2019.01.002
UR  - https://pub.dzne.de/record/141053
ER  -