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@ARTICLE{Smith:141053,
      author       = {Smith, Eric E and Biessels, Geert Jan and De Guio,
                      François and de Leeuw, Frank Erik and Duchesne, Simon and
                      Düring, Marco and Frayne, Richard and Ikram, M Arfan and
                      Jouvent, Eric and MacIntosh, Bradley J and Thrippleton,
                      Michael J and Vernooij, Meike W and Adams, Hieab and Backes,
                      Walter H and Ballerini, Lucia and Black, Sandra E and Chen,
                      Christopher and Corriveau, Rod and DeCarli, Charles and
                      Greenberg, Steven M and Gurol, M Edip and Ingrisch, Michael
                      and Job, Dominic and Lam, Bonnie Y K and Launer, Lenore J
                      and Linn, Jennifer and McCreary, Cheryl R and Mok, Vincent C
                      T and Pantoni, Leonardo and Pike, G Bruce and Ramirez, Joel
                      and Reijmer, Yael D and Romero, Jose Rafael and Ropele,
                      Stefan and Rost, Natalia S and Sachdev, Perminder S and
                      Scott, Christopher J M and Seshadri, Sudha and Sharma, Mukul
                      and Sourbron, Steven and Steketee, Rebecca M E and Swartz,
                      Richard H and van Oostenbrugge, Robert and van Osch,
                      Matthias and van Rooden, Sanneke and Viswanathan, Anand and
                      Werring, David and Dichgans, Martin and Wardlaw, Joanna M},
      title        = {{H}armonizing brain magnetic resonance imaging methods for
                      vascular contributions to neurodegeneration.},
      journal      = {Alzheimer's $\&$ dementia / Diagnosis, assessment $\&$
                      disease monitoring},
      volume       = {11},
      number       = {1},
      issn         = {2352-8729},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-07375},
      pages        = {191-204},
      year         = {2019},
      abstract     = {Many consequences of cerebrovascular disease are
                      identifiable by magnetic resonance imaging (MRI), but
                      variation in methods limits multicenter studies and pooling
                      of data. The European Union Joint Program on
                      Neurodegenerative Diseases (EU JPND) funded the HARmoNizing
                      Brain Imaging MEthodS for VaScular Contributions to
                      Neurodegeneration (HARNESS) initiative, with a focus on
                      cerebral small vessel disease.Surveys, teleconferences, and
                      an in-person workshop were used to identify gaps in
                      knowledge and to develop tools for harmonizing imaging and
                      analysis.A framework for neuroimaging biomarker development
                      was developed based on validating repeatability and
                      reproducibility, biological principles, and feasibility of
                      implementation. The status of current MRI biomarkers was
                      reviewed. A website was created at
                      www.harness-neuroimaging.org with acquisition protocols, a
                      software database, rating scales and case report forms, and
                      a deidentified MRI repository.The HARNESS initiative
                      provides resources to reduce variability in measurement in
                      MRI studies of cerebral small vessel disease.},
      subtyp        = {Review Article},
      cin          = {München common / AG Levin},
      ddc          = {610},
      cid          = {I:(DE-2719)6000016 / I:(DE-2719)1111016},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30859119},
      pmc          = {pmc:PMC6396326},
      doi          = {10.1016/j.dadm.2019.01.002},
      url          = {https://pub.dzne.de/record/141053},
}